CD4(+) T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy

The impaired T cell responses observed in chronic hepatitis B (HBV) patients are considered to contribute to the chronicity of the infection. Research on this impairment has been focused on CD8(+) T cells because of their cytotoxic effector function; however, CD4(+) T cells are crucial in the proper...

Descripción completa

Detalles Bibliográficos
Autores principales: Buschow, Sonja I., Jansen, Diahann T. S. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148211/
https://www.ncbi.nlm.nih.gov/pubmed/34066322
http://dx.doi.org/10.3390/cells10051114
Descripción
Sumario:The impaired T cell responses observed in chronic hepatitis B (HBV) patients are considered to contribute to the chronicity of the infection. Research on this impairment has been focused on CD8(+) T cells because of their cytotoxic effector function; however, CD4(+) T cells are crucial in the proper development of these long-lasting effector CD8(+) T cells. In this review, we summarize what is known about CD4(+) T cells in chronic HBV infection and discuss the importance and opportunities of including CD4(+) T cells in T cell-directed immunotherapeutic strategies to cure chronic HBV.

Ejemplares similares