CD4(+) T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy

The impaired T cell responses observed in chronic hepatitis B (HBV) patients are considered to contribute to the chronicity of the infection. Research on this impairment has been focused on CD8(+) T cells because of their cytotoxic effector function; however, CD4(+) T cells are crucial in the proper...

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Detalles Bibliográficos
Autores principales: Buschow, Sonja I., Jansen, Diahann T. S. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148211/
https://www.ncbi.nlm.nih.gov/pubmed/34066322
http://dx.doi.org/10.3390/cells10051114
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author Buschow, Sonja I.
Jansen, Diahann T. S. L.
author_facet Buschow, Sonja I.
Jansen, Diahann T. S. L.
author_sort Buschow, Sonja I.
collection PubMed
description The impaired T cell responses observed in chronic hepatitis B (HBV) patients are considered to contribute to the chronicity of the infection. Research on this impairment has been focused on CD8(+) T cells because of their cytotoxic effector function; however, CD4(+) T cells are crucial in the proper development of these long-lasting effector CD8(+) T cells. In this review, we summarize what is known about CD4(+) T cells in chronic HBV infection and discuss the importance and opportunities of including CD4(+) T cells in T cell-directed immunotherapeutic strategies to cure chronic HBV.
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spelling pubmed-81482112021-05-26 CD4(+) T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy Buschow, Sonja I. Jansen, Diahann T. S. L. Cells Review The impaired T cell responses observed in chronic hepatitis B (HBV) patients are considered to contribute to the chronicity of the infection. Research on this impairment has been focused on CD8(+) T cells because of their cytotoxic effector function; however, CD4(+) T cells are crucial in the proper development of these long-lasting effector CD8(+) T cells. In this review, we summarize what is known about CD4(+) T cells in chronic HBV infection and discuss the importance and opportunities of including CD4(+) T cells in T cell-directed immunotherapeutic strategies to cure chronic HBV. MDPI 2021-05-06 /pmc/articles/PMC8148211/ /pubmed/34066322 http://dx.doi.org/10.3390/cells10051114 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Buschow, Sonja I.
Jansen, Diahann T. S. L.
CD4(+) T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy
title CD4(+) T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy
title_full CD4(+) T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy
title_fullStr CD4(+) T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy
title_full_unstemmed CD4(+) T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy
title_short CD4(+) T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy
title_sort cd4(+) t cells in chronic hepatitis b and t cell-directed immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148211/
https://www.ncbi.nlm.nih.gov/pubmed/34066322
http://dx.doi.org/10.3390/cells10051114
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