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Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture

Cardiac amyloidosis (CA) is a rare systemic disease determined by the extracellular deposition of amyloid protein in the heart. The protein can accumulate in any part of the heart: myocardium, vessels, endocardium, valves, epicardium and parietal pericardium. The types of CA include the following ty...

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Autores principales: Kozak, Sylwia, Ulbrich, Krzysztof, Migacz, Maciej, Szydło, Krzysztof, Mizia-Stec, Katarzyna, Holecki, Michał
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148212/
https://www.ncbi.nlm.nih.gov/pubmed/34066321
http://dx.doi.org/10.3390/medicina57050450
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author Kozak, Sylwia
Ulbrich, Krzysztof
Migacz, Maciej
Szydło, Krzysztof
Mizia-Stec, Katarzyna
Holecki, Michał
author_facet Kozak, Sylwia
Ulbrich, Krzysztof
Migacz, Maciej
Szydło, Krzysztof
Mizia-Stec, Katarzyna
Holecki, Michał
author_sort Kozak, Sylwia
collection PubMed
description Cardiac amyloidosis (CA) is a rare systemic disease determined by the extracellular deposition of amyloid protein in the heart. The protein can accumulate in any part of the heart: myocardium, vessels, endocardium, valves, epicardium and parietal pericardium. The types of CA include the following types: light chain (AL), amyloidosis AA (Amyloid A) and transthyretin (ATTR). The detection of specific subtypes remains of great importance to implement the targeted treatment. We present the case of a 65-year-old woman, who was admitted with severe deterioration of exercise capacity, a bilateral reduction of physiological vesicular murmur, ascites and edema of lower extremities. CA was suspected due to echocardiographic examination results, which led to further examination and final diagnosis. The aim of this study is to improve the disease awareness among clinicians and shorten the delay between the first symptoms and the diagnosis establishment resulting in a better outcome.
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spelling pubmed-81482122021-05-26 Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture Kozak, Sylwia Ulbrich, Krzysztof Migacz, Maciej Szydło, Krzysztof Mizia-Stec, Katarzyna Holecki, Michał Medicina (Kaunas) Case Report Cardiac amyloidosis (CA) is a rare systemic disease determined by the extracellular deposition of amyloid protein in the heart. The protein can accumulate in any part of the heart: myocardium, vessels, endocardium, valves, epicardium and parietal pericardium. The types of CA include the following types: light chain (AL), amyloidosis AA (Amyloid A) and transthyretin (ATTR). The detection of specific subtypes remains of great importance to implement the targeted treatment. We present the case of a 65-year-old woman, who was admitted with severe deterioration of exercise capacity, a bilateral reduction of physiological vesicular murmur, ascites and edema of lower extremities. CA was suspected due to echocardiographic examination results, which led to further examination and final diagnosis. The aim of this study is to improve the disease awareness among clinicians and shorten the delay between the first symptoms and the diagnosis establishment resulting in a better outcome. MDPI 2021-05-06 /pmc/articles/PMC8148212/ /pubmed/34066321 http://dx.doi.org/10.3390/medicina57050450 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kozak, Sylwia
Ulbrich, Krzysztof
Migacz, Maciej
Szydło, Krzysztof
Mizia-Stec, Katarzyna
Holecki, Michał
Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture
title Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture
title_full Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture
title_fullStr Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture
title_full_unstemmed Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture
title_short Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture
title_sort cardiac amyloidosis-challenging diagnosis and unclear clinical picture
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148212/
https://www.ncbi.nlm.nih.gov/pubmed/34066321
http://dx.doi.org/10.3390/medicina57050450
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