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Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture
Cardiac amyloidosis (CA) is a rare systemic disease determined by the extracellular deposition of amyloid protein in the heart. The protein can accumulate in any part of the heart: myocardium, vessels, endocardium, valves, epicardium and parietal pericardium. The types of CA include the following ty...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148212/ https://www.ncbi.nlm.nih.gov/pubmed/34066321 http://dx.doi.org/10.3390/medicina57050450 |
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author | Kozak, Sylwia Ulbrich, Krzysztof Migacz, Maciej Szydło, Krzysztof Mizia-Stec, Katarzyna Holecki, Michał |
author_facet | Kozak, Sylwia Ulbrich, Krzysztof Migacz, Maciej Szydło, Krzysztof Mizia-Stec, Katarzyna Holecki, Michał |
author_sort | Kozak, Sylwia |
collection | PubMed |
description | Cardiac amyloidosis (CA) is a rare systemic disease determined by the extracellular deposition of amyloid protein in the heart. The protein can accumulate in any part of the heart: myocardium, vessels, endocardium, valves, epicardium and parietal pericardium. The types of CA include the following types: light chain (AL), amyloidosis AA (Amyloid A) and transthyretin (ATTR). The detection of specific subtypes remains of great importance to implement the targeted treatment. We present the case of a 65-year-old woman, who was admitted with severe deterioration of exercise capacity, a bilateral reduction of physiological vesicular murmur, ascites and edema of lower extremities. CA was suspected due to echocardiographic examination results, which led to further examination and final diagnosis. The aim of this study is to improve the disease awareness among clinicians and shorten the delay between the first symptoms and the diagnosis establishment resulting in a better outcome. |
format | Online Article Text |
id | pubmed-8148212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81482122021-05-26 Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture Kozak, Sylwia Ulbrich, Krzysztof Migacz, Maciej Szydło, Krzysztof Mizia-Stec, Katarzyna Holecki, Michał Medicina (Kaunas) Case Report Cardiac amyloidosis (CA) is a rare systemic disease determined by the extracellular deposition of amyloid protein in the heart. The protein can accumulate in any part of the heart: myocardium, vessels, endocardium, valves, epicardium and parietal pericardium. The types of CA include the following types: light chain (AL), amyloidosis AA (Amyloid A) and transthyretin (ATTR). The detection of specific subtypes remains of great importance to implement the targeted treatment. We present the case of a 65-year-old woman, who was admitted with severe deterioration of exercise capacity, a bilateral reduction of physiological vesicular murmur, ascites and edema of lower extremities. CA was suspected due to echocardiographic examination results, which led to further examination and final diagnosis. The aim of this study is to improve the disease awareness among clinicians and shorten the delay between the first symptoms and the diagnosis establishment resulting in a better outcome. MDPI 2021-05-06 /pmc/articles/PMC8148212/ /pubmed/34066321 http://dx.doi.org/10.3390/medicina57050450 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Kozak, Sylwia Ulbrich, Krzysztof Migacz, Maciej Szydło, Krzysztof Mizia-Stec, Katarzyna Holecki, Michał Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture |
title | Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture |
title_full | Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture |
title_fullStr | Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture |
title_full_unstemmed | Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture |
title_short | Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture |
title_sort | cardiac amyloidosis-challenging diagnosis and unclear clinical picture |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148212/ https://www.ncbi.nlm.nih.gov/pubmed/34066321 http://dx.doi.org/10.3390/medicina57050450 |
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