Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques

Here, we assessed the efficacy of a short-course multimodal therapy (enrofloxacin, azithromycin, fenbendazole, and paromomycin) to eliminate common macaque endemic pathogens (EPs) and evaluated its impact on gastrointestinal (GI) microbiota, mucosal integrity, and local and systemic inflammation in...

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Detalles Bibliográficos
Autores principales: Bochart, Rachele M., Busman-Sahay, Kathleen, Bondoc, Stephen, Morrow, David W., Ortiz, Alexandra M., Fennessey, Christine M., Fischer, Miranda B., Shiel, Oriene, Swanson, Tonya, Shriver-Munsch, Christine M., Crank, Hugh B., Armantrout, Kimberly M., Barber-Axthelm, Aaron M., Langner, Charlotte, Moats, Cassandra R., Labriola, Caralyn S., MacAllister, Rhonda, Axthelm, Michael K., Brenchley, Jason M., Keele, Brandon F., Estes, Jacob D., Hansen, Scott G., Smedley, Jeremy V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148316/
https://www.ncbi.nlm.nih.gov/pubmed/33970966
http://dx.doi.org/10.1371/journal.ppat.1009565

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