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Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study

With electronic (e)-liquids containing cannabis components easily available, many anecdotal examples of cannabis vaping using electronic cigarette devices have been reported. For electronic cigarette cannabis vaping, there are potential risks of secondary indoor air pollution from vapers. However, q...

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Autores principales: Kuga, Kazuki, Ito, Kazuhide, Chen, Wenhao, Wang, Ping, Fowles, Jeff, Kumagai, Kazukiyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148323/
https://www.ncbi.nlm.nih.gov/pubmed/33983924
http://dx.doi.org/10.1371/journal.pcbi.1009004
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author Kuga, Kazuki
Ito, Kazuhide
Chen, Wenhao
Wang, Ping
Fowles, Jeff
Kumagai, Kazukiyo
author_facet Kuga, Kazuki
Ito, Kazuhide
Chen, Wenhao
Wang, Ping
Fowles, Jeff
Kumagai, Kazukiyo
author_sort Kuga, Kazuki
collection PubMed
description With electronic (e)-liquids containing cannabis components easily available, many anecdotal examples of cannabis vaping using electronic cigarette devices have been reported. For electronic cigarette cannabis vaping, there are potential risks of secondary indoor air pollution from vapers. However, quantitative and accurate prediction of the inhalation and dermal exposure of a passive smoker in the same room is difficult to achieve due to the ethical constraints on subject experiments. The numerical method, i.e., in silico method, is a powerful tool to complement these experiments with real humans. In this study, we adopted a computer-simulated person that has been validated from multiple perspectives for prediction accuracy. We then conducted an in silico study to elucidate secondary indoor air pollution and passive smoking associated with cannabis vaping using an electronic cigarette device in an indoor environment. The aerosols exhaled by a cannabis vaper were confirmed to be a secondary emission source in an indoor environment; non-smokers were exposed to these aerosols via respiratory and dermal pathways. Tetrahydrocannabinol was used as a model chemical compound for the exposure study. Its uptake by the non-smoker through inhalation and dermal exposure under a worst-case scenario was estimated to be 5.9% and 2.6% of the exhaled quantity from an e-cigarette cannabis user, respectively.
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spelling pubmed-81483232021-06-07 Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study Kuga, Kazuki Ito, Kazuhide Chen, Wenhao Wang, Ping Fowles, Jeff Kumagai, Kazukiyo PLoS Comput Biol Research Article With electronic (e)-liquids containing cannabis components easily available, many anecdotal examples of cannabis vaping using electronic cigarette devices have been reported. For electronic cigarette cannabis vaping, there are potential risks of secondary indoor air pollution from vapers. However, quantitative and accurate prediction of the inhalation and dermal exposure of a passive smoker in the same room is difficult to achieve due to the ethical constraints on subject experiments. The numerical method, i.e., in silico method, is a powerful tool to complement these experiments with real humans. In this study, we adopted a computer-simulated person that has been validated from multiple perspectives for prediction accuracy. We then conducted an in silico study to elucidate secondary indoor air pollution and passive smoking associated with cannabis vaping using an electronic cigarette device in an indoor environment. The aerosols exhaled by a cannabis vaper were confirmed to be a secondary emission source in an indoor environment; non-smokers were exposed to these aerosols via respiratory and dermal pathways. Tetrahydrocannabinol was used as a model chemical compound for the exposure study. Its uptake by the non-smoker through inhalation and dermal exposure under a worst-case scenario was estimated to be 5.9% and 2.6% of the exhaled quantity from an e-cigarette cannabis user, respectively. Public Library of Science 2021-05-13 /pmc/articles/PMC8148323/ /pubmed/33983924 http://dx.doi.org/10.1371/journal.pcbi.1009004 Text en © 2021 Kuga et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kuga, Kazuki
Ito, Kazuhide
Chen, Wenhao
Wang, Ping
Fowles, Jeff
Kumagai, Kazukiyo
Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study
title Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study
title_full Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study
title_fullStr Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study
title_full_unstemmed Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study
title_short Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study
title_sort secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148323/
https://www.ncbi.nlm.nih.gov/pubmed/33983924
http://dx.doi.org/10.1371/journal.pcbi.1009004
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