Cargando…
Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study
With electronic (e)-liquids containing cannabis components easily available, many anecdotal examples of cannabis vaping using electronic cigarette devices have been reported. For electronic cigarette cannabis vaping, there are potential risks of secondary indoor air pollution from vapers. However, q...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148323/ https://www.ncbi.nlm.nih.gov/pubmed/33983924 http://dx.doi.org/10.1371/journal.pcbi.1009004 |
_version_ | 1783697811935592448 |
---|---|
author | Kuga, Kazuki Ito, Kazuhide Chen, Wenhao Wang, Ping Fowles, Jeff Kumagai, Kazukiyo |
author_facet | Kuga, Kazuki Ito, Kazuhide Chen, Wenhao Wang, Ping Fowles, Jeff Kumagai, Kazukiyo |
author_sort | Kuga, Kazuki |
collection | PubMed |
description | With electronic (e)-liquids containing cannabis components easily available, many anecdotal examples of cannabis vaping using electronic cigarette devices have been reported. For electronic cigarette cannabis vaping, there are potential risks of secondary indoor air pollution from vapers. However, quantitative and accurate prediction of the inhalation and dermal exposure of a passive smoker in the same room is difficult to achieve due to the ethical constraints on subject experiments. The numerical method, i.e., in silico method, is a powerful tool to complement these experiments with real humans. In this study, we adopted a computer-simulated person that has been validated from multiple perspectives for prediction accuracy. We then conducted an in silico study to elucidate secondary indoor air pollution and passive smoking associated with cannabis vaping using an electronic cigarette device in an indoor environment. The aerosols exhaled by a cannabis vaper were confirmed to be a secondary emission source in an indoor environment; non-smokers were exposed to these aerosols via respiratory and dermal pathways. Tetrahydrocannabinol was used as a model chemical compound for the exposure study. Its uptake by the non-smoker through inhalation and dermal exposure under a worst-case scenario was estimated to be 5.9% and 2.6% of the exhaled quantity from an e-cigarette cannabis user, respectively. |
format | Online Article Text |
id | pubmed-8148323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-81483232021-06-07 Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study Kuga, Kazuki Ito, Kazuhide Chen, Wenhao Wang, Ping Fowles, Jeff Kumagai, Kazukiyo PLoS Comput Biol Research Article With electronic (e)-liquids containing cannabis components easily available, many anecdotal examples of cannabis vaping using electronic cigarette devices have been reported. For electronic cigarette cannabis vaping, there are potential risks of secondary indoor air pollution from vapers. However, quantitative and accurate prediction of the inhalation and dermal exposure of a passive smoker in the same room is difficult to achieve due to the ethical constraints on subject experiments. The numerical method, i.e., in silico method, is a powerful tool to complement these experiments with real humans. In this study, we adopted a computer-simulated person that has been validated from multiple perspectives for prediction accuracy. We then conducted an in silico study to elucidate secondary indoor air pollution and passive smoking associated with cannabis vaping using an electronic cigarette device in an indoor environment. The aerosols exhaled by a cannabis vaper were confirmed to be a secondary emission source in an indoor environment; non-smokers were exposed to these aerosols via respiratory and dermal pathways. Tetrahydrocannabinol was used as a model chemical compound for the exposure study. Its uptake by the non-smoker through inhalation and dermal exposure under a worst-case scenario was estimated to be 5.9% and 2.6% of the exhaled quantity from an e-cigarette cannabis user, respectively. Public Library of Science 2021-05-13 /pmc/articles/PMC8148323/ /pubmed/33983924 http://dx.doi.org/10.1371/journal.pcbi.1009004 Text en © 2021 Kuga et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kuga, Kazuki Ito, Kazuhide Chen, Wenhao Wang, Ping Fowles, Jeff Kumagai, Kazukiyo Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study |
title | Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study |
title_full | Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study |
title_fullStr | Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study |
title_full_unstemmed | Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study |
title_short | Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study |
title_sort | secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148323/ https://www.ncbi.nlm.nih.gov/pubmed/33983924 http://dx.doi.org/10.1371/journal.pcbi.1009004 |
work_keys_str_mv | AT kugakazuki secondaryindoorairpollutionandpassivesmokingassociatedwithcannabissmokingusingelectriccigarettedevicedemonstrativeinsilicostudy AT itokazuhide secondaryindoorairpollutionandpassivesmokingassociatedwithcannabissmokingusingelectriccigarettedevicedemonstrativeinsilicostudy AT chenwenhao secondaryindoorairpollutionandpassivesmokingassociatedwithcannabissmokingusingelectriccigarettedevicedemonstrativeinsilicostudy AT wangping secondaryindoorairpollutionandpassivesmokingassociatedwithcannabissmokingusingelectriccigarettedevicedemonstrativeinsilicostudy AT fowlesjeff secondaryindoorairpollutionandpassivesmokingassociatedwithcannabissmokingusingelectriccigarettedevicedemonstrativeinsilicostudy AT kumagaikazukiyo secondaryindoorairpollutionandpassivesmokingassociatedwithcannabissmokingusingelectriccigarettedevicedemonstrativeinsilicostudy |