A Novel Approach for a Chip-Sized Scanning Optical Microscope

The recent advances in chip-size microscopy based on optical scanning with spatially resolved nano-illumination light sources are presented. This new straightforward technique takes advantage of the currently achieved miniaturization of LEDs in fully addressable arrays. These nano-LEDs are used to s...

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Detalles Bibliográficos
Autores principales: Canals, Joan, Franch, Nil, Moro, Victor, Moreno, Sergio, Prades, Juan Daniel, Romano-Rodríguez, Albert, Bornemann, Steffen, Bezshlyakh, Daria D., Waag, Andreas, Vogelbacher, Florian, Schrittwieser, Stefan, Kluczyk-Korch, Katarzyna, Auf der Maur, Matthias, Di Carlo, Aldo, Diéguez, Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148435/
https://www.ncbi.nlm.nih.gov/pubmed/34066638
http://dx.doi.org/10.3390/mi12050527
Descripción
Sumario:The recent advances in chip-size microscopy based on optical scanning with spatially resolved nano-illumination light sources are presented. This new straightforward technique takes advantage of the currently achieved miniaturization of LEDs in fully addressable arrays. These nano-LEDs are used to scan the sample with a resolution comparable to the LED sizes, giving rise to chip-sized scanning optical microscopes without mechanical parts or optical accessories. The operation principle and the potential of this new kind of microscope are analyzed through three different implementations of decreasing LED dimensions from 20 µm down to 200 nm.

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