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Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment

During breast cancer therapy, paclitaxel and trastuzumab are both associated with adverse effects such as chemotherapy-induced peripheral neuropathy and other systemic side effects including ocular complications. Corneal nerves are considered part of the peripheral nervous system and can be imaged n...

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Autores principales: Sterenczak, Katharina A., Stache, Nadine, Bohn, Sebastian, Allgeier, Stephan, Köhler, Bernd, Bartschat, Andreas, George, Christian, Guthoff, Rudolf F., Stachs, Oliver, Stachs, Angrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148560/
https://www.ncbi.nlm.nih.gov/pubmed/34066952
http://dx.doi.org/10.3390/diagnostics11050838
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author Sterenczak, Katharina A.
Stache, Nadine
Bohn, Sebastian
Allgeier, Stephan
Köhler, Bernd
Bartschat, Andreas
George, Christian
Guthoff, Rudolf F.
Stachs, Oliver
Stachs, Angrit
author_facet Sterenczak, Katharina A.
Stache, Nadine
Bohn, Sebastian
Allgeier, Stephan
Köhler, Bernd
Bartschat, Andreas
George, Christian
Guthoff, Rudolf F.
Stachs, Oliver
Stachs, Angrit
author_sort Sterenczak, Katharina A.
collection PubMed
description During breast cancer therapy, paclitaxel and trastuzumab are both associated with adverse effects such as chemotherapy-induced peripheral neuropathy and other systemic side effects including ocular complications. Corneal nerves are considered part of the peripheral nervous system and can be imaged non-invasively by confocal laser scanning microscopy (CLSM) on the cellular level. Thus, in vivo CLSM imaging of structures of the corneal subbasal nerve plexus (SNP) such as sensory nerves or dendritic cells (DCs) can be a powerful tool for the assessment of corneal complications during cancer treatment. During the present study, the SNP of a breast cancer patient was analyzed over time by using large-scale in vivo CLSM in the course of paclitaxel and trastuzumab therapy. The same corneal regions could be re-identified over time. While the subbasal nerve morphology did not alter significantly, a change in dendritic cell density and an additional local burst within the first 11 weeks of therapy was detected, indicating treatment-mediated corneal inflammatory processes. Ocular structures such as nerves and dendritic cells could represent useful biomarkers for the assessment of ocular adverse effects during cancer therapy and their management, leading to a better visual prognosis.
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spelling pubmed-81485602021-05-26 Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment Sterenczak, Katharina A. Stache, Nadine Bohn, Sebastian Allgeier, Stephan Köhler, Bernd Bartschat, Andreas George, Christian Guthoff, Rudolf F. Stachs, Oliver Stachs, Angrit Diagnostics (Basel) Interesting Images During breast cancer therapy, paclitaxel and trastuzumab are both associated with adverse effects such as chemotherapy-induced peripheral neuropathy and other systemic side effects including ocular complications. Corneal nerves are considered part of the peripheral nervous system and can be imaged non-invasively by confocal laser scanning microscopy (CLSM) on the cellular level. Thus, in vivo CLSM imaging of structures of the corneal subbasal nerve plexus (SNP) such as sensory nerves or dendritic cells (DCs) can be a powerful tool for the assessment of corneal complications during cancer treatment. During the present study, the SNP of a breast cancer patient was analyzed over time by using large-scale in vivo CLSM in the course of paclitaxel and trastuzumab therapy. The same corneal regions could be re-identified over time. While the subbasal nerve morphology did not alter significantly, a change in dendritic cell density and an additional local burst within the first 11 weeks of therapy was detected, indicating treatment-mediated corneal inflammatory processes. Ocular structures such as nerves and dendritic cells could represent useful biomarkers for the assessment of ocular adverse effects during cancer therapy and their management, leading to a better visual prognosis. MDPI 2021-05-07 /pmc/articles/PMC8148560/ /pubmed/34066952 http://dx.doi.org/10.3390/diagnostics11050838 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Interesting Images
Sterenczak, Katharina A.
Stache, Nadine
Bohn, Sebastian
Allgeier, Stephan
Köhler, Bernd
Bartschat, Andreas
George, Christian
Guthoff, Rudolf F.
Stachs, Oliver
Stachs, Angrit
Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment
title Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment
title_full Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment
title_fullStr Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment
title_full_unstemmed Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment
title_short Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment
title_sort burst of corneal dendritic cells during trastuzumab and paclitaxel treatment
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148560/
https://www.ncbi.nlm.nih.gov/pubmed/34066952
http://dx.doi.org/10.3390/diagnostics11050838
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