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Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment
During breast cancer therapy, paclitaxel and trastuzumab are both associated with adverse effects such as chemotherapy-induced peripheral neuropathy and other systemic side effects including ocular complications. Corneal nerves are considered part of the peripheral nervous system and can be imaged n...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148560/ https://www.ncbi.nlm.nih.gov/pubmed/34066952 http://dx.doi.org/10.3390/diagnostics11050838 |
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author | Sterenczak, Katharina A. Stache, Nadine Bohn, Sebastian Allgeier, Stephan Köhler, Bernd Bartschat, Andreas George, Christian Guthoff, Rudolf F. Stachs, Oliver Stachs, Angrit |
author_facet | Sterenczak, Katharina A. Stache, Nadine Bohn, Sebastian Allgeier, Stephan Köhler, Bernd Bartschat, Andreas George, Christian Guthoff, Rudolf F. Stachs, Oliver Stachs, Angrit |
author_sort | Sterenczak, Katharina A. |
collection | PubMed |
description | During breast cancer therapy, paclitaxel and trastuzumab are both associated with adverse effects such as chemotherapy-induced peripheral neuropathy and other systemic side effects including ocular complications. Corneal nerves are considered part of the peripheral nervous system and can be imaged non-invasively by confocal laser scanning microscopy (CLSM) on the cellular level. Thus, in vivo CLSM imaging of structures of the corneal subbasal nerve plexus (SNP) such as sensory nerves or dendritic cells (DCs) can be a powerful tool for the assessment of corneal complications during cancer treatment. During the present study, the SNP of a breast cancer patient was analyzed over time by using large-scale in vivo CLSM in the course of paclitaxel and trastuzumab therapy. The same corneal regions could be re-identified over time. While the subbasal nerve morphology did not alter significantly, a change in dendritic cell density and an additional local burst within the first 11 weeks of therapy was detected, indicating treatment-mediated corneal inflammatory processes. Ocular structures such as nerves and dendritic cells could represent useful biomarkers for the assessment of ocular adverse effects during cancer therapy and their management, leading to a better visual prognosis. |
format | Online Article Text |
id | pubmed-8148560 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81485602021-05-26 Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment Sterenczak, Katharina A. Stache, Nadine Bohn, Sebastian Allgeier, Stephan Köhler, Bernd Bartschat, Andreas George, Christian Guthoff, Rudolf F. Stachs, Oliver Stachs, Angrit Diagnostics (Basel) Interesting Images During breast cancer therapy, paclitaxel and trastuzumab are both associated with adverse effects such as chemotherapy-induced peripheral neuropathy and other systemic side effects including ocular complications. Corneal nerves are considered part of the peripheral nervous system and can be imaged non-invasively by confocal laser scanning microscopy (CLSM) on the cellular level. Thus, in vivo CLSM imaging of structures of the corneal subbasal nerve plexus (SNP) such as sensory nerves or dendritic cells (DCs) can be a powerful tool for the assessment of corneal complications during cancer treatment. During the present study, the SNP of a breast cancer patient was analyzed over time by using large-scale in vivo CLSM in the course of paclitaxel and trastuzumab therapy. The same corneal regions could be re-identified over time. While the subbasal nerve morphology did not alter significantly, a change in dendritic cell density and an additional local burst within the first 11 weeks of therapy was detected, indicating treatment-mediated corneal inflammatory processes. Ocular structures such as nerves and dendritic cells could represent useful biomarkers for the assessment of ocular adverse effects during cancer therapy and their management, leading to a better visual prognosis. MDPI 2021-05-07 /pmc/articles/PMC8148560/ /pubmed/34066952 http://dx.doi.org/10.3390/diagnostics11050838 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Interesting Images Sterenczak, Katharina A. Stache, Nadine Bohn, Sebastian Allgeier, Stephan Köhler, Bernd Bartschat, Andreas George, Christian Guthoff, Rudolf F. Stachs, Oliver Stachs, Angrit Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment |
title | Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment |
title_full | Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment |
title_fullStr | Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment |
title_full_unstemmed | Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment |
title_short | Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment |
title_sort | burst of corneal dendritic cells during trastuzumab and paclitaxel treatment |
topic | Interesting Images |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148560/ https://www.ncbi.nlm.nih.gov/pubmed/34066952 http://dx.doi.org/10.3390/diagnostics11050838 |
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