In Vivo Models to Study the Pathogenesis of Extra-Respiratory Complications of Influenza A Virus Infection

Animal models are an inimitable method to study the systemic pathogenesis of virus-induced disease. Extra-respiratory complications of influenza A virus infections are not extensively studied even though they are often associated with severe disease and mortality. Here we review and recommend mammal...

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Autores principales: Veldhuis Kroeze, Edwin, Bauer, Lisa, Caliendo, Valentina, van Riel, Debby
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148586/
https://www.ncbi.nlm.nih.gov/pubmed/34066589
http://dx.doi.org/10.3390/v13050848
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author Veldhuis Kroeze, Edwin
Bauer, Lisa
Caliendo, Valentina
van Riel, Debby
author_facet Veldhuis Kroeze, Edwin
Bauer, Lisa
Caliendo, Valentina
van Riel, Debby
author_sort Veldhuis Kroeze, Edwin
collection PubMed
description Animal models are an inimitable method to study the systemic pathogenesis of virus-induced disease. Extra-respiratory complications of influenza A virus infections are not extensively studied even though they are often associated with severe disease and mortality. Here we review and recommend mammalian animal models that can be used to study extra-respiratory complications of the central nervous system and cardiovascular system as well as involvement of the eye, placenta, fetus, lacteal gland, liver, pancreas, intestinal tract, and lymphoid tissues during influenza A virus infections.
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spelling pubmed-81485862021-05-26 In Vivo Models to Study the Pathogenesis of Extra-Respiratory Complications of Influenza A Virus Infection Veldhuis Kroeze, Edwin Bauer, Lisa Caliendo, Valentina van Riel, Debby Viruses Review Animal models are an inimitable method to study the systemic pathogenesis of virus-induced disease. Extra-respiratory complications of influenza A virus infections are not extensively studied even though they are often associated with severe disease and mortality. Here we review and recommend mammalian animal models that can be used to study extra-respiratory complications of the central nervous system and cardiovascular system as well as involvement of the eye, placenta, fetus, lacteal gland, liver, pancreas, intestinal tract, and lymphoid tissues during influenza A virus infections. MDPI 2021-05-06 /pmc/articles/PMC8148586/ /pubmed/34066589 http://dx.doi.org/10.3390/v13050848 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Veldhuis Kroeze, Edwin
Bauer, Lisa
Caliendo, Valentina
van Riel, Debby
In Vivo Models to Study the Pathogenesis of Extra-Respiratory Complications of Influenza A Virus Infection
title In Vivo Models to Study the Pathogenesis of Extra-Respiratory Complications of Influenza A Virus Infection
title_full In Vivo Models to Study the Pathogenesis of Extra-Respiratory Complications of Influenza A Virus Infection
title_fullStr In Vivo Models to Study the Pathogenesis of Extra-Respiratory Complications of Influenza A Virus Infection
title_full_unstemmed In Vivo Models to Study the Pathogenesis of Extra-Respiratory Complications of Influenza A Virus Infection
title_short In Vivo Models to Study the Pathogenesis of Extra-Respiratory Complications of Influenza A Virus Infection
title_sort in vivo models to study the pathogenesis of extra-respiratory complications of influenza a virus infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148586/
https://www.ncbi.nlm.nih.gov/pubmed/34066589
http://dx.doi.org/10.3390/v13050848
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