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Macrophages and Stem Cells—Two to Tango for Tissue Repair?

Macrophages (MCs) are present in all tissues, not only supporting homeostasis, but also playing an important role in organogenesis, post-injury regeneration, and diseases. They are a heterogeneous cell population due to their origin, tissue specificity, and polarization in response to aggression fac...

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Autores principales: Manole, Emilia, Niculite, Cristina, Lambrescu, Ioana Maria, Gaina, Gisela, Ioghen, Octavian, Ceafalan, Laura Cristina, Hinescu, Mihail Eugen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148606/
https://www.ncbi.nlm.nih.gov/pubmed/34066618
http://dx.doi.org/10.3390/biom11050697
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author Manole, Emilia
Niculite, Cristina
Lambrescu, Ioana Maria
Gaina, Gisela
Ioghen, Octavian
Ceafalan, Laura Cristina
Hinescu, Mihail Eugen
author_facet Manole, Emilia
Niculite, Cristina
Lambrescu, Ioana Maria
Gaina, Gisela
Ioghen, Octavian
Ceafalan, Laura Cristina
Hinescu, Mihail Eugen
author_sort Manole, Emilia
collection PubMed
description Macrophages (MCs) are present in all tissues, not only supporting homeostasis, but also playing an important role in organogenesis, post-injury regeneration, and diseases. They are a heterogeneous cell population due to their origin, tissue specificity, and polarization in response to aggression factors, depending on environmental cues. Thus, as pro-inflammatory M1 phagocytic MCs, they contribute to tissue damage and even fibrosis, but the anti-inflammatory M2 phenotype participates in repairing processes and wound healing through a molecular interplay with most cells in adult stem cell niches. In this review, we emphasize MC phenotypic heterogeneity in health and disease, highlighting their systemic and systematic contribution to tissue homeostasis and repair. Unraveling the intervention of both resident and migrated MCs on the behavior of stem cells and the regulation of the stem cell niche is crucial for opening new perspectives for novel therapeutic strategies in different diseases.
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spelling pubmed-81486062021-05-26 Macrophages and Stem Cells—Two to Tango for Tissue Repair? Manole, Emilia Niculite, Cristina Lambrescu, Ioana Maria Gaina, Gisela Ioghen, Octavian Ceafalan, Laura Cristina Hinescu, Mihail Eugen Biomolecules Review Macrophages (MCs) are present in all tissues, not only supporting homeostasis, but also playing an important role in organogenesis, post-injury regeneration, and diseases. They are a heterogeneous cell population due to their origin, tissue specificity, and polarization in response to aggression factors, depending on environmental cues. Thus, as pro-inflammatory M1 phagocytic MCs, they contribute to tissue damage and even fibrosis, but the anti-inflammatory M2 phenotype participates in repairing processes and wound healing through a molecular interplay with most cells in adult stem cell niches. In this review, we emphasize MC phenotypic heterogeneity in health and disease, highlighting their systemic and systematic contribution to tissue homeostasis and repair. Unraveling the intervention of both resident and migrated MCs on the behavior of stem cells and the regulation of the stem cell niche is crucial for opening new perspectives for novel therapeutic strategies in different diseases. MDPI 2021-05-06 /pmc/articles/PMC8148606/ /pubmed/34066618 http://dx.doi.org/10.3390/biom11050697 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Manole, Emilia
Niculite, Cristina
Lambrescu, Ioana Maria
Gaina, Gisela
Ioghen, Octavian
Ceafalan, Laura Cristina
Hinescu, Mihail Eugen
Macrophages and Stem Cells—Two to Tango for Tissue Repair?
title Macrophages and Stem Cells—Two to Tango for Tissue Repair?
title_full Macrophages and Stem Cells—Two to Tango for Tissue Repair?
title_fullStr Macrophages and Stem Cells—Two to Tango for Tissue Repair?
title_full_unstemmed Macrophages and Stem Cells—Two to Tango for Tissue Repair?
title_short Macrophages and Stem Cells—Two to Tango for Tissue Repair?
title_sort macrophages and stem cells—two to tango for tissue repair?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148606/
https://www.ncbi.nlm.nih.gov/pubmed/34066618
http://dx.doi.org/10.3390/biom11050697
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