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Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair
PURPOSE: The aim of this work was to analyze the effect of fibrin biopolymer sealant (FS) associated or not to aquatic exercise (AE) on the calcaneal tendon repair. METHODS: Forty-four female Wistar rats were randomly divided into four experimental groups: Lesion control (L), Lesion and FS (LS), Les...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em
Cirurgia
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148814/ https://www.ncbi.nlm.nih.gov/pubmed/34037082 http://dx.doi.org/10.1590/ACB360407 |
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author | Hidd, Silvia Maria Cardoso Magalhães Tim, Carla Roberta Dutra, Eneas de Freitas Maia, Antônio Luiz Martins Assis, Lívia Ferreira, Rui Seabra Barraviera, Benedito Silva, José Figueiredo Amaral, Marcello Magri |
author_facet | Hidd, Silvia Maria Cardoso Magalhães Tim, Carla Roberta Dutra, Eneas de Freitas Maia, Antônio Luiz Martins Assis, Lívia Ferreira, Rui Seabra Barraviera, Benedito Silva, José Figueiredo Amaral, Marcello Magri |
author_sort | Hidd, Silvia Maria Cardoso Magalhães |
collection | PubMed |
description | PURPOSE: The aim of this work was to analyze the effect of fibrin biopolymer sealant (FS) associated or not to aquatic exercise (AE) on the calcaneal tendon repair. METHODS: Forty-four female Wistar rats were randomly divided into four experimental groups: Lesion control (L), Lesion and FS (LS), Lesion and AE (LE) and Lesion and FS associated to AE (LSE). The edema volume (EV), collagen ratio, and histopathological analysis were evaluated after 7, 14, and 21 days of partial tendon transection. RESULTS: The EV was statistically reduced for all treatment groups after 7 and 21 days when compared to L group. The LS and LSE had the highest EV reduction after 21 days of treatment. The FS group didn’t induce tissue necrosis or infections on the histopathological analysis. It was observed tenocytes proliferation, granulation tissue and collagen formation in the tendon partial transection area in the FS group. The LSE demonstrated higher amount of granulation tissue and increased the collagen deposition at the injury site. CONCLUSIONS: Our data suggests that the therapeutic potential of the association of heterologous fibrin biopolymer sealant with aquatic exercise program should be further explored as it may stimulate the regeneration phase and optimize calcaneal tendon recovery. |
format | Online Article Text |
id | pubmed-8148814 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em
Cirurgia |
record_format | MEDLINE/PubMed |
spelling | pubmed-81488142021-06-04 Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair Hidd, Silvia Maria Cardoso Magalhães Tim, Carla Roberta Dutra, Eneas de Freitas Maia, Antônio Luiz Martins Assis, Lívia Ferreira, Rui Seabra Barraviera, Benedito Silva, José Figueiredo Amaral, Marcello Magri Acta Cir Bras Original Article PURPOSE: The aim of this work was to analyze the effect of fibrin biopolymer sealant (FS) associated or not to aquatic exercise (AE) on the calcaneal tendon repair. METHODS: Forty-four female Wistar rats were randomly divided into four experimental groups: Lesion control (L), Lesion and FS (LS), Lesion and AE (LE) and Lesion and FS associated to AE (LSE). The edema volume (EV), collagen ratio, and histopathological analysis were evaluated after 7, 14, and 21 days of partial tendon transection. RESULTS: The EV was statistically reduced for all treatment groups after 7 and 21 days when compared to L group. The LS and LSE had the highest EV reduction after 21 days of treatment. The FS group didn’t induce tissue necrosis or infections on the histopathological analysis. It was observed tenocytes proliferation, granulation tissue and collagen formation in the tendon partial transection area in the FS group. The LSE demonstrated higher amount of granulation tissue and increased the collagen deposition at the injury site. CONCLUSIONS: Our data suggests that the therapeutic potential of the association of heterologous fibrin biopolymer sealant with aquatic exercise program should be further explored as it may stimulate the regeneration phase and optimize calcaneal tendon recovery. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2021-05-21 /pmc/articles/PMC8148814/ /pubmed/34037082 http://dx.doi.org/10.1590/ACB360407 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Hidd, Silvia Maria Cardoso Magalhães Tim, Carla Roberta Dutra, Eneas de Freitas Maia, Antônio Luiz Martins Assis, Lívia Ferreira, Rui Seabra Barraviera, Benedito Silva, José Figueiredo Amaral, Marcello Magri Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair |
title | Fibrin biopolymer sealant and aquatic exercise association for
calcaneal tendon repair |
title_full | Fibrin biopolymer sealant and aquatic exercise association for
calcaneal tendon repair |
title_fullStr | Fibrin biopolymer sealant and aquatic exercise association for
calcaneal tendon repair |
title_full_unstemmed | Fibrin biopolymer sealant and aquatic exercise association for
calcaneal tendon repair |
title_short | Fibrin biopolymer sealant and aquatic exercise association for
calcaneal tendon repair |
title_sort | fibrin biopolymer sealant and aquatic exercise association for
calcaneal tendon repair |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148814/ https://www.ncbi.nlm.nih.gov/pubmed/34037082 http://dx.doi.org/10.1590/ACB360407 |
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