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Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair

PURPOSE: The aim of this work was to analyze the effect of fibrin biopolymer sealant (FS) associated or not to aquatic exercise (AE) on the calcaneal tendon repair. METHODS: Forty-four female Wistar rats were randomly divided into four experimental groups: Lesion control (L), Lesion and FS (LS), Les...

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Autores principales: Hidd, Silvia Maria Cardoso Magalhães, Tim, Carla Roberta, Dutra, Eneas de Freitas, Maia, Antônio Luiz Martins, Assis, Lívia, Ferreira, Rui Seabra, Barraviera, Benedito, Silva, José Figueiredo, Amaral, Marcello Magri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148814/
https://www.ncbi.nlm.nih.gov/pubmed/34037082
http://dx.doi.org/10.1590/ACB360407
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author Hidd, Silvia Maria Cardoso Magalhães
Tim, Carla Roberta
Dutra, Eneas de Freitas
Maia, Antônio Luiz Martins
Assis, Lívia
Ferreira, Rui Seabra
Barraviera, Benedito
Silva, José Figueiredo
Amaral, Marcello Magri
author_facet Hidd, Silvia Maria Cardoso Magalhães
Tim, Carla Roberta
Dutra, Eneas de Freitas
Maia, Antônio Luiz Martins
Assis, Lívia
Ferreira, Rui Seabra
Barraviera, Benedito
Silva, José Figueiredo
Amaral, Marcello Magri
author_sort Hidd, Silvia Maria Cardoso Magalhães
collection PubMed
description PURPOSE: The aim of this work was to analyze the effect of fibrin biopolymer sealant (FS) associated or not to aquatic exercise (AE) on the calcaneal tendon repair. METHODS: Forty-four female Wistar rats were randomly divided into four experimental groups: Lesion control (L), Lesion and FS (LS), Lesion and AE (LE) and Lesion and FS associated to AE (LSE). The edema volume (EV), collagen ratio, and histopathological analysis were evaluated after 7, 14, and 21 days of partial tendon transection. RESULTS: The EV was statistically reduced for all treatment groups after 7 and 21 days when compared to L group. The LS and LSE had the highest EV reduction after 21 days of treatment. The FS group didn’t induce tissue necrosis or infections on the histopathological analysis. It was observed tenocytes proliferation, granulation tissue and collagen formation in the tendon partial transection area in the FS group. The LSE demonstrated higher amount of granulation tissue and increased the collagen deposition at the injury site. CONCLUSIONS: Our data suggests that the therapeutic potential of the association of heterologous fibrin biopolymer sealant with aquatic exercise program should be further explored as it may stimulate the regeneration phase and optimize calcaneal tendon recovery.
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spelling pubmed-81488142021-06-04 Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair Hidd, Silvia Maria Cardoso Magalhães Tim, Carla Roberta Dutra, Eneas de Freitas Maia, Antônio Luiz Martins Assis, Lívia Ferreira, Rui Seabra Barraviera, Benedito Silva, José Figueiredo Amaral, Marcello Magri Acta Cir Bras Original Article PURPOSE: The aim of this work was to analyze the effect of fibrin biopolymer sealant (FS) associated or not to aquatic exercise (AE) on the calcaneal tendon repair. METHODS: Forty-four female Wistar rats were randomly divided into four experimental groups: Lesion control (L), Lesion and FS (LS), Lesion and AE (LE) and Lesion and FS associated to AE (LSE). The edema volume (EV), collagen ratio, and histopathological analysis were evaluated after 7, 14, and 21 days of partial tendon transection. RESULTS: The EV was statistically reduced for all treatment groups after 7 and 21 days when compared to L group. The LS and LSE had the highest EV reduction after 21 days of treatment. The FS group didn’t induce tissue necrosis or infections on the histopathological analysis. It was observed tenocytes proliferation, granulation tissue and collagen formation in the tendon partial transection area in the FS group. The LSE demonstrated higher amount of granulation tissue and increased the collagen deposition at the injury site. CONCLUSIONS: Our data suggests that the therapeutic potential of the association of heterologous fibrin biopolymer sealant with aquatic exercise program should be further explored as it may stimulate the regeneration phase and optimize calcaneal tendon recovery. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2021-05-21 /pmc/articles/PMC8148814/ /pubmed/34037082 http://dx.doi.org/10.1590/ACB360407 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hidd, Silvia Maria Cardoso Magalhães
Tim, Carla Roberta
Dutra, Eneas de Freitas
Maia, Antônio Luiz Martins
Assis, Lívia
Ferreira, Rui Seabra
Barraviera, Benedito
Silva, José Figueiredo
Amaral, Marcello Magri
Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair
title Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair
title_full Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair
title_fullStr Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair
title_full_unstemmed Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair
title_short Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair
title_sort fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148814/
https://www.ncbi.nlm.nih.gov/pubmed/34037082
http://dx.doi.org/10.1590/ACB360407
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