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Characterization of Headache in COVID-19: a Retrospective Multicenter Study

Headache is the most common neurological symptom in COVID-19, reported in 6.5 to 34% of patients. Few studies have analyzed its characteristics, and some of them included cases without laboratory confirmation or reported only critical patients. We aimed to analyze the clinical characteristics of COV...

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Autores principales: dos Anjos de Paula, Rafael César, de Maria Frota Vasconcelos, Thaís, da Costa, Francisco Bruno Santana, de Brito, Lara Albuquerque, Torres, Danielle Mesquita, Moura, Alissa Elen Formiga, Oliveira, Danilo Nunes, de Lima Henn, Guilherme Alves, Rodrigues, Pedro Gustavo Barros, de Sousa Pereira, Isabelle, Braga, Ianna Lacerda Sampaio, Rocha, Felipe Araújo, Frota, Norberto Anízio Ferreira, Carvalho, Fernanda Martins Maia, Pitombeira, Milena Sales, Tavares-Junior, José Wagner Leonel, Montenegro, Raquel Carvalho, Braga-Neto, Pedro, Nóbrega, Paulo Ribeiro, Sobreira-Neto, Manoel Alves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148871/
https://www.ncbi.nlm.nih.gov/pubmed/34036488
http://dx.doi.org/10.1007/s12035-021-02430-w
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author dos Anjos de Paula, Rafael César
de Maria Frota Vasconcelos, Thaís
da Costa, Francisco Bruno Santana
de Brito, Lara Albuquerque
Torres, Danielle Mesquita
Moura, Alissa Elen Formiga
Oliveira, Danilo Nunes
de Lima Henn, Guilherme Alves
Rodrigues, Pedro Gustavo Barros
de Sousa Pereira, Isabelle
Braga, Ianna Lacerda Sampaio
Rocha, Felipe Araújo
Frota, Norberto Anízio Ferreira
Carvalho, Fernanda Martins Maia
Pitombeira, Milena Sales
Tavares-Junior, José Wagner Leonel
Montenegro, Raquel Carvalho
Braga-Neto, Pedro
Nóbrega, Paulo Ribeiro
Sobreira-Neto, Manoel Alves
author_facet dos Anjos de Paula, Rafael César
de Maria Frota Vasconcelos, Thaís
da Costa, Francisco Bruno Santana
de Brito, Lara Albuquerque
Torres, Danielle Mesquita
Moura, Alissa Elen Formiga
Oliveira, Danilo Nunes
de Lima Henn, Guilherme Alves
Rodrigues, Pedro Gustavo Barros
de Sousa Pereira, Isabelle
Braga, Ianna Lacerda Sampaio
Rocha, Felipe Araújo
Frota, Norberto Anízio Ferreira
Carvalho, Fernanda Martins Maia
Pitombeira, Milena Sales
Tavares-Junior, José Wagner Leonel
Montenegro, Raquel Carvalho
Braga-Neto, Pedro
Nóbrega, Paulo Ribeiro
Sobreira-Neto, Manoel Alves
author_sort dos Anjos de Paula, Rafael César
collection PubMed
description Headache is the most common neurological symptom in COVID-19, reported in 6.5 to 34% of patients. Few studies have analyzed its characteristics, and some of them included cases without laboratory confirmation or reported only critical patients. We aimed to analyze the clinical characteristics of COVID-19 associated headache in laboratory-confirmed cases. We conducted a retrospective evaluation of patients with COVID-19 and neurological symptoms. Patients who reported headache answered an interview about its clinical characteristics. Twenty-four patients with COVID-19 associated headache completed the interview. Mean age of patients was 53.8 (standard deviation—17.44), and 14 out of 24 (58.3%) were male. The majority (75%) had no previous history of headache. Fever was documented in 19 out of the 24 patients (79.1%). Headache was predominantly bifrontal or holocranial, in pressure, during hours, worsening with cough or physical activity. COVID-19 headache tends to appear in the first days of symptoms, be either frontal or holocranial and last for days. The quality of pain in pressure and the worsening with cough or physical activity were reported in most cases. We have not found any characteristic that could differentiate COVID-19 associated headache from other causes of headache, possibly because of its multifactorial mechanism.
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spelling pubmed-81488712021-05-26 Characterization of Headache in COVID-19: a Retrospective Multicenter Study dos Anjos de Paula, Rafael César de Maria Frota Vasconcelos, Thaís da Costa, Francisco Bruno Santana de Brito, Lara Albuquerque Torres, Danielle Mesquita Moura, Alissa Elen Formiga Oliveira, Danilo Nunes de Lima Henn, Guilherme Alves Rodrigues, Pedro Gustavo Barros de Sousa Pereira, Isabelle Braga, Ianna Lacerda Sampaio Rocha, Felipe Araújo Frota, Norberto Anízio Ferreira Carvalho, Fernanda Martins Maia Pitombeira, Milena Sales Tavares-Junior, José Wagner Leonel Montenegro, Raquel Carvalho Braga-Neto, Pedro Nóbrega, Paulo Ribeiro Sobreira-Neto, Manoel Alves Mol Neurobiol Article Headache is the most common neurological symptom in COVID-19, reported in 6.5 to 34% of patients. Few studies have analyzed its characteristics, and some of them included cases without laboratory confirmation or reported only critical patients. We aimed to analyze the clinical characteristics of COVID-19 associated headache in laboratory-confirmed cases. We conducted a retrospective evaluation of patients with COVID-19 and neurological symptoms. Patients who reported headache answered an interview about its clinical characteristics. Twenty-four patients with COVID-19 associated headache completed the interview. Mean age of patients was 53.8 (standard deviation—17.44), and 14 out of 24 (58.3%) were male. The majority (75%) had no previous history of headache. Fever was documented in 19 out of the 24 patients (79.1%). Headache was predominantly bifrontal or holocranial, in pressure, during hours, worsening with cough or physical activity. COVID-19 headache tends to appear in the first days of symptoms, be either frontal or holocranial and last for days. The quality of pain in pressure and the worsening with cough or physical activity were reported in most cases. We have not found any characteristic that could differentiate COVID-19 associated headache from other causes of headache, possibly because of its multifactorial mechanism. Springer US 2021-05-25 2021 /pmc/articles/PMC8148871/ /pubmed/34036488 http://dx.doi.org/10.1007/s12035-021-02430-w Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
dos Anjos de Paula, Rafael César
de Maria Frota Vasconcelos, Thaís
da Costa, Francisco Bruno Santana
de Brito, Lara Albuquerque
Torres, Danielle Mesquita
Moura, Alissa Elen Formiga
Oliveira, Danilo Nunes
de Lima Henn, Guilherme Alves
Rodrigues, Pedro Gustavo Barros
de Sousa Pereira, Isabelle
Braga, Ianna Lacerda Sampaio
Rocha, Felipe Araújo
Frota, Norberto Anízio Ferreira
Carvalho, Fernanda Martins Maia
Pitombeira, Milena Sales
Tavares-Junior, José Wagner Leonel
Montenegro, Raquel Carvalho
Braga-Neto, Pedro
Nóbrega, Paulo Ribeiro
Sobreira-Neto, Manoel Alves
Characterization of Headache in COVID-19: a Retrospective Multicenter Study
title Characterization of Headache in COVID-19: a Retrospective Multicenter Study
title_full Characterization of Headache in COVID-19: a Retrospective Multicenter Study
title_fullStr Characterization of Headache in COVID-19: a Retrospective Multicenter Study
title_full_unstemmed Characterization of Headache in COVID-19: a Retrospective Multicenter Study
title_short Characterization of Headache in COVID-19: a Retrospective Multicenter Study
title_sort characterization of headache in covid-19: a retrospective multicenter study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148871/
https://www.ncbi.nlm.nih.gov/pubmed/34036488
http://dx.doi.org/10.1007/s12035-021-02430-w
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