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Potential alternative treatment approach for pediatric patient with diffusely infiltrative primary rhabdomyosarcoma of the liver

Primary hepatic rhabdomyosarcoma is rare, making decisions regarding locoregional management with resection and/or conventional radiation difficult. We present a novel treatment approach for a pediatric patient diagnosed with rhabdomyosarcoma diffusely involving the liver. This patient underwent tre...

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Autores principales: Patel, Rushil, Roberson, John, Prakash, Devina, Meyer, Rina, Hogan, Laura, Azmy, Christeen, Suprenant, Valmore, Ryu, Samuel, Stessin, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Via Medica 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149128/
https://www.ncbi.nlm.nih.gov/pubmed/34046225
http://dx.doi.org/10.5603/RPOR.a2021.0008
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author Patel, Rushil
Roberson, John
Prakash, Devina
Meyer, Rina
Hogan, Laura
Azmy, Christeen
Suprenant, Valmore
Ryu, Samuel
Stessin, Alexander
author_facet Patel, Rushil
Roberson, John
Prakash, Devina
Meyer, Rina
Hogan, Laura
Azmy, Christeen
Suprenant, Valmore
Ryu, Samuel
Stessin, Alexander
author_sort Patel, Rushil
collection PubMed
description Primary hepatic rhabdomyosarcoma is rare, making decisions regarding locoregional management with resection and/or conventional radiation difficult. We present a novel treatment approach for a pediatric patient diagnosed with rhabdomyosarcoma diffusely involving the liver. This patient underwent treatment with yttrium-90 (Y-90) microspheres followed by external beam radiation therapy (EBRT ) to residual disease, interdigitated with systemic chemotherapy. Initial post-radiation imaging showed significant response to treatment, and she experienced minimal acute toxicities and no long-term toxicities. She developed recurrent PET-avid disease 23 months after Y-90 treatment, necessitating further local and continued systemic therapies. We report on the tumor control following Y-90 and EBRT treatment.
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spelling pubmed-81491282021-05-26 Potential alternative treatment approach for pediatric patient with diffusely infiltrative primary rhabdomyosarcoma of the liver Patel, Rushil Roberson, John Prakash, Devina Meyer, Rina Hogan, Laura Azmy, Christeen Suprenant, Valmore Ryu, Samuel Stessin, Alexander Rep Pract Oncol Radiother Case Report Primary hepatic rhabdomyosarcoma is rare, making decisions regarding locoregional management with resection and/or conventional radiation difficult. We present a novel treatment approach for a pediatric patient diagnosed with rhabdomyosarcoma diffusely involving the liver. This patient underwent treatment with yttrium-90 (Y-90) microspheres followed by external beam radiation therapy (EBRT ) to residual disease, interdigitated with systemic chemotherapy. Initial post-radiation imaging showed significant response to treatment, and she experienced minimal acute toxicities and no long-term toxicities. She developed recurrent PET-avid disease 23 months after Y-90 treatment, necessitating further local and continued systemic therapies. We report on the tumor control following Y-90 and EBRT treatment. Via Medica 2021-02-25 /pmc/articles/PMC8149128/ /pubmed/34046225 http://dx.doi.org/10.5603/RPOR.a2021.0008 Text en © 2021 Greater Poland Cancer Centre https://creativecommons.org/licenses/by-nc-nd/4.0/This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially
spellingShingle Case Report
Patel, Rushil
Roberson, John
Prakash, Devina
Meyer, Rina
Hogan, Laura
Azmy, Christeen
Suprenant, Valmore
Ryu, Samuel
Stessin, Alexander
Potential alternative treatment approach for pediatric patient with diffusely infiltrative primary rhabdomyosarcoma of the liver
title Potential alternative treatment approach for pediatric patient with diffusely infiltrative primary rhabdomyosarcoma of the liver
title_full Potential alternative treatment approach for pediatric patient with diffusely infiltrative primary rhabdomyosarcoma of the liver
title_fullStr Potential alternative treatment approach for pediatric patient with diffusely infiltrative primary rhabdomyosarcoma of the liver
title_full_unstemmed Potential alternative treatment approach for pediatric patient with diffusely infiltrative primary rhabdomyosarcoma of the liver
title_short Potential alternative treatment approach for pediatric patient with diffusely infiltrative primary rhabdomyosarcoma of the liver
title_sort potential alternative treatment approach for pediatric patient with diffusely infiltrative primary rhabdomyosarcoma of the liver
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149128/
https://www.ncbi.nlm.nih.gov/pubmed/34046225
http://dx.doi.org/10.5603/RPOR.a2021.0008
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