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A radiobiological comparison of hypo-fractionation versus conventional fractionation for breast cancer 3D-conformal radiation therapy

BACKGROUND: The present research was aimed to compare the toxicity and effectiveness of conventional fractionated radiotherapy versus hypo-fractionated radiotherapy in breast cancer utilizing a radiobiological model. MATERIALS AND METHODS: Thirty-five left-sided breast cancer patients without involv...

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Autores principales: Kazemzadeh, Arezoo, Abedi, Iraj, Amouheidari, Alireza, Shirvany, Atefeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Via Medica 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149130/
https://www.ncbi.nlm.nih.gov/pubmed/34046218
http://dx.doi.org/10.5603/RPOR.a2021.0015
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author Kazemzadeh, Arezoo
Abedi, Iraj
Amouheidari, Alireza
Shirvany, Atefeh
author_facet Kazemzadeh, Arezoo
Abedi, Iraj
Amouheidari, Alireza
Shirvany, Atefeh
author_sort Kazemzadeh, Arezoo
collection PubMed
description BACKGROUND: The present research was aimed to compare the toxicity and effectiveness of conventional fractionated radiotherapy versus hypo-fractionated radiotherapy in breast cancer utilizing a radiobiological model. MATERIALS AND METHODS: Thirty-five left-sided breast cancer patients without involvement of the supraclavicular and axillary lymph nodes (with the nodal stage of N0) that had been treated with conventional or hypo-fractionated were incorporated in this study. A radiobiological model was performed to foretell normal tissue complication probability (NTCP) and tumor control probability (TCP). RESULTS: The data represented that TCP values for conventional and hypo-fractionated regimens were 99.16 ± 0.09 and 95.96 ± 0.48, respectively (p = 0.00). Moreover, the NTCP values of the lung for conventional and hypo-fractionated treatment were 0.024 versus 0.13 (p = 0.035), respectively. Also, NTCP values of the heart were equal to zero for both regimens. CONCLUSION: In summary, hypo-fractionated regimens had comparable efficacy to conventional fraction radiation therapy in the case of dosimetry parameters for patients who had left breast cancer. But, utilizing the radiobiological model, conventional fractionated regimens presented better results compared to hypo-fractionated regimens.
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spelling pubmed-81491302021-05-26 A radiobiological comparison of hypo-fractionation versus conventional fractionation for breast cancer 3D-conformal radiation therapy Kazemzadeh, Arezoo Abedi, Iraj Amouheidari, Alireza Shirvany, Atefeh Rep Pract Oncol Radiother Research Paper BACKGROUND: The present research was aimed to compare the toxicity and effectiveness of conventional fractionated radiotherapy versus hypo-fractionated radiotherapy in breast cancer utilizing a radiobiological model. MATERIALS AND METHODS: Thirty-five left-sided breast cancer patients without involvement of the supraclavicular and axillary lymph nodes (with the nodal stage of N0) that had been treated with conventional or hypo-fractionated were incorporated in this study. A radiobiological model was performed to foretell normal tissue complication probability (NTCP) and tumor control probability (TCP). RESULTS: The data represented that TCP values for conventional and hypo-fractionated regimens were 99.16 ± 0.09 and 95.96 ± 0.48, respectively (p = 0.00). Moreover, the NTCP values of the lung for conventional and hypo-fractionated treatment were 0.024 versus 0.13 (p = 0.035), respectively. Also, NTCP values of the heart were equal to zero for both regimens. CONCLUSION: In summary, hypo-fractionated regimens had comparable efficacy to conventional fraction radiation therapy in the case of dosimetry parameters for patients who had left breast cancer. But, utilizing the radiobiological model, conventional fractionated regimens presented better results compared to hypo-fractionated regimens. Via Medica 2021-02-25 /pmc/articles/PMC8149130/ /pubmed/34046218 http://dx.doi.org/10.5603/RPOR.a2021.0015 Text en © 2021 Greater Poland Cancer Centre https://creativecommons.org/licenses/by-nc-nd/4.0/This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially
spellingShingle Research Paper
Kazemzadeh, Arezoo
Abedi, Iraj
Amouheidari, Alireza
Shirvany, Atefeh
A radiobiological comparison of hypo-fractionation versus conventional fractionation for breast cancer 3D-conformal radiation therapy
title A radiobiological comparison of hypo-fractionation versus conventional fractionation for breast cancer 3D-conformal radiation therapy
title_full A radiobiological comparison of hypo-fractionation versus conventional fractionation for breast cancer 3D-conformal radiation therapy
title_fullStr A radiobiological comparison of hypo-fractionation versus conventional fractionation for breast cancer 3D-conformal radiation therapy
title_full_unstemmed A radiobiological comparison of hypo-fractionation versus conventional fractionation for breast cancer 3D-conformal radiation therapy
title_short A radiobiological comparison of hypo-fractionation versus conventional fractionation for breast cancer 3D-conformal radiation therapy
title_sort radiobiological comparison of hypo-fractionation versus conventional fractionation for breast cancer 3d-conformal radiation therapy
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149130/
https://www.ncbi.nlm.nih.gov/pubmed/34046218
http://dx.doi.org/10.5603/RPOR.a2021.0015
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