Urinary Trypsin Inhibitor Protects Tight Junctions of Septic Pulmonary Capillary Endothelial Cells by Regulating the Functions of Macrophages

BACKGROUND: Our previous study found that urinary trypsin inhibitor (ulinastatin, UTI) protected tight junctions (TJs) of lung endothelia via TNF-α inhibition, thereby alleviating pulmonary capillary permeability in septic rats. As the activated macrophage is the main source of TNF-α in sepsis, we s...

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Detalles Bibliográficos
Autores principales: Wang, Ruijie, Song, Wenliang, Xie, Chengyuan, Zhong, Wenhong, Xu, Hui, Zhou, Qiuping, Deng, Yiyu, Hong, Yimei, Li, Xin, Fang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149216/
https://www.ncbi.nlm.nih.gov/pubmed/34045879
http://dx.doi.org/10.2147/JIR.S303577

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