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CD4(+)CD25(+) Regulatory T Cells in Intracranial Thrombi Are Inversely Correlated with Hemorrhagic Transformation after Thrombectomy: A Clinical-Immunohistochemical Analysis of Acute Ischemic Stroke

Mechanical thrombectomy is not only effective for managing patients with acute ischemic stroke (AIS), but it also enables a valuable histological analysis of thrombi. Previous studies indicated that regulatory T cells (Treg) adoptive transfer might alleviate the hemorrhagic transformation. However,...

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Autores principales: Gong, Li, Zheng, Xiaoran, Zhang, Weiyan, Shu, Zhongwen, Wang, Haichao, Dong, Qiong, Sun, Letao, Zhang, Xiang, Zhao, Yanxin, Liu, Xueyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149217/
https://www.ncbi.nlm.nih.gov/pubmed/34055193
http://dx.doi.org/10.1155/2021/3143248
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author Gong, Li
Zheng, Xiaoran
Zhang, Weiyan
Shu, Zhongwen
Wang, Haichao
Dong, Qiong
Sun, Letao
Zhang, Xiang
Zhao, Yanxin
Liu, Xueyuan
author_facet Gong, Li
Zheng, Xiaoran
Zhang, Weiyan
Shu, Zhongwen
Wang, Haichao
Dong, Qiong
Sun, Letao
Zhang, Xiang
Zhao, Yanxin
Liu, Xueyuan
author_sort Gong, Li
collection PubMed
description Mechanical thrombectomy is not only effective for managing patients with acute ischemic stroke (AIS), but it also enables a valuable histological analysis of thrombi. Previous studies indicated that regulatory T cells (Treg) adoptive transfer might alleviate the hemorrhagic transformation. However, whether Treg in intracranial thrombi correlates with hemorrhagic transformation after mechanical thrombectomy remains unclear. This study mainly analyzed the colocation of Treg markers in serial thrombus sections stained serially for CD4 and CD25 in groups of hemorrhagic or nonhemorrhagic transformation. Second, to investigate whether these immunohistochemical parameters could provide any additional information beyond hemorrhagic transformation, we compared the overlap between Treg markers among other groups, such as functional outcomes, stroke subtypes, and gender. Our results showed that the number of CD4(+)CD25(+) Treg cells was lower in the hemorrhagic transformation thrombi than in the nonhemorrhagic group (p < 0.001) but there were no significant differences otherwise. The present finding of CD4(+)CD25(+) Treg cell reductions in thrombi associated with hemorrhagic transformation provides the histological evidence supporting that thromboinflammation might involve in the pathological process of an acute stroke after mechanical thrombectomy.
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spelling pubmed-81492172021-05-27 CD4(+)CD25(+) Regulatory T Cells in Intracranial Thrombi Are Inversely Correlated with Hemorrhagic Transformation after Thrombectomy: A Clinical-Immunohistochemical Analysis of Acute Ischemic Stroke Gong, Li Zheng, Xiaoran Zhang, Weiyan Shu, Zhongwen Wang, Haichao Dong, Qiong Sun, Letao Zhang, Xiang Zhao, Yanxin Liu, Xueyuan Oxid Med Cell Longev Research Article Mechanical thrombectomy is not only effective for managing patients with acute ischemic stroke (AIS), but it also enables a valuable histological analysis of thrombi. Previous studies indicated that regulatory T cells (Treg) adoptive transfer might alleviate the hemorrhagic transformation. However, whether Treg in intracranial thrombi correlates with hemorrhagic transformation after mechanical thrombectomy remains unclear. This study mainly analyzed the colocation of Treg markers in serial thrombus sections stained serially for CD4 and CD25 in groups of hemorrhagic or nonhemorrhagic transformation. Second, to investigate whether these immunohistochemical parameters could provide any additional information beyond hemorrhagic transformation, we compared the overlap between Treg markers among other groups, such as functional outcomes, stroke subtypes, and gender. Our results showed that the number of CD4(+)CD25(+) Treg cells was lower in the hemorrhagic transformation thrombi than in the nonhemorrhagic group (p < 0.001) but there were no significant differences otherwise. The present finding of CD4(+)CD25(+) Treg cell reductions in thrombi associated with hemorrhagic transformation provides the histological evidence supporting that thromboinflammation might involve in the pathological process of an acute stroke after mechanical thrombectomy. Hindawi 2021-05-17 /pmc/articles/PMC8149217/ /pubmed/34055193 http://dx.doi.org/10.1155/2021/3143248 Text en Copyright © 2021 Li Gong et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gong, Li
Zheng, Xiaoran
Zhang, Weiyan
Shu, Zhongwen
Wang, Haichao
Dong, Qiong
Sun, Letao
Zhang, Xiang
Zhao, Yanxin
Liu, Xueyuan
CD4(+)CD25(+) Regulatory T Cells in Intracranial Thrombi Are Inversely Correlated with Hemorrhagic Transformation after Thrombectomy: A Clinical-Immunohistochemical Analysis of Acute Ischemic Stroke
title CD4(+)CD25(+) Regulatory T Cells in Intracranial Thrombi Are Inversely Correlated with Hemorrhagic Transformation after Thrombectomy: A Clinical-Immunohistochemical Analysis of Acute Ischemic Stroke
title_full CD4(+)CD25(+) Regulatory T Cells in Intracranial Thrombi Are Inversely Correlated with Hemorrhagic Transformation after Thrombectomy: A Clinical-Immunohistochemical Analysis of Acute Ischemic Stroke
title_fullStr CD4(+)CD25(+) Regulatory T Cells in Intracranial Thrombi Are Inversely Correlated with Hemorrhagic Transformation after Thrombectomy: A Clinical-Immunohistochemical Analysis of Acute Ischemic Stroke
title_full_unstemmed CD4(+)CD25(+) Regulatory T Cells in Intracranial Thrombi Are Inversely Correlated with Hemorrhagic Transformation after Thrombectomy: A Clinical-Immunohistochemical Analysis of Acute Ischemic Stroke
title_short CD4(+)CD25(+) Regulatory T Cells in Intracranial Thrombi Are Inversely Correlated with Hemorrhagic Transformation after Thrombectomy: A Clinical-Immunohistochemical Analysis of Acute Ischemic Stroke
title_sort cd4(+)cd25(+) regulatory t cells in intracranial thrombi are inversely correlated with hemorrhagic transformation after thrombectomy: a clinical-immunohistochemical analysis of acute ischemic stroke
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149217/
https://www.ncbi.nlm.nih.gov/pubmed/34055193
http://dx.doi.org/10.1155/2021/3143248
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