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Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection
Prior immunological exposure to dengue virus can be both protective and disease-enhancing during subsequent infections with different dengue virus serotypes. We provide here a systematic, longitudinal analysis of B cell, T cell, and antibody responses in the same patients. Antibody responses as well...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149372/ https://www.ncbi.nlm.nih.gov/pubmed/34095880 http://dx.doi.org/10.1016/j.xcrm.2021.100278 |
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author | Rouers, Angeline Chng, Melissa Hui Yen Lee, Bernett Rajapakse, Menaka P. Kaur, Kaval Toh, Ying Xiu Sathiakumar, Durgalakshmi Loy, Thomas Thein, Tun-Linn Lim, Vanessa W.X. Singhal, Amit Yeo, Tsin Wen Leo, Yee-Sin Vora, Kalpit A. Casimiro, Danilo Lim, Bing Tucker-Kellogg, Lisa Rivino, Laura Newell, Evan W. Fink, Katja |
author_facet | Rouers, Angeline Chng, Melissa Hui Yen Lee, Bernett Rajapakse, Menaka P. Kaur, Kaval Toh, Ying Xiu Sathiakumar, Durgalakshmi Loy, Thomas Thein, Tun-Linn Lim, Vanessa W.X. Singhal, Amit Yeo, Tsin Wen Leo, Yee-Sin Vora, Kalpit A. Casimiro, Danilo Lim, Bing Tucker-Kellogg, Lisa Rivino, Laura Newell, Evan W. Fink, Katja |
author_sort | Rouers, Angeline |
collection | PubMed |
description | Prior immunological exposure to dengue virus can be both protective and disease-enhancing during subsequent infections with different dengue virus serotypes. We provide here a systematic, longitudinal analysis of B cell, T cell, and antibody responses in the same patients. Antibody responses as well as T and B cell activation differentiate primary from secondary responses. Hospitalization is associated with lower frequencies of activated, terminally differentiated T cells and higher percentages of effector memory CD4 T cells. Patients with more severe disease tend to have higher percentages of plasmablasts. This does not translate into long-term antibody titers, since neutralizing titers after 6 months correlate with percentages of specific memory B cells, but not with acute plasmablast activation. Overall, our unbiased analysis reveals associations between cellular profiles and disease severity, opening opportunities to study immunopathology in dengue disease and the potential predictive value of these parameters. |
format | Online Article Text |
id | pubmed-8149372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-81493722021-06-03 Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection Rouers, Angeline Chng, Melissa Hui Yen Lee, Bernett Rajapakse, Menaka P. Kaur, Kaval Toh, Ying Xiu Sathiakumar, Durgalakshmi Loy, Thomas Thein, Tun-Linn Lim, Vanessa W.X. Singhal, Amit Yeo, Tsin Wen Leo, Yee-Sin Vora, Kalpit A. Casimiro, Danilo Lim, Bing Tucker-Kellogg, Lisa Rivino, Laura Newell, Evan W. Fink, Katja Cell Rep Med Article Prior immunological exposure to dengue virus can be both protective and disease-enhancing during subsequent infections with different dengue virus serotypes. We provide here a systematic, longitudinal analysis of B cell, T cell, and antibody responses in the same patients. Antibody responses as well as T and B cell activation differentiate primary from secondary responses. Hospitalization is associated with lower frequencies of activated, terminally differentiated T cells and higher percentages of effector memory CD4 T cells. Patients with more severe disease tend to have higher percentages of plasmablasts. This does not translate into long-term antibody titers, since neutralizing titers after 6 months correlate with percentages of specific memory B cells, but not with acute plasmablast activation. Overall, our unbiased analysis reveals associations between cellular profiles and disease severity, opening opportunities to study immunopathology in dengue disease and the potential predictive value of these parameters. Elsevier 2021-05-18 /pmc/articles/PMC8149372/ /pubmed/34095880 http://dx.doi.org/10.1016/j.xcrm.2021.100278 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Rouers, Angeline Chng, Melissa Hui Yen Lee, Bernett Rajapakse, Menaka P. Kaur, Kaval Toh, Ying Xiu Sathiakumar, Durgalakshmi Loy, Thomas Thein, Tun-Linn Lim, Vanessa W.X. Singhal, Amit Yeo, Tsin Wen Leo, Yee-Sin Vora, Kalpit A. Casimiro, Danilo Lim, Bing Tucker-Kellogg, Lisa Rivino, Laura Newell, Evan W. Fink, Katja Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection |
title | Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection |
title_full | Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection |
title_fullStr | Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection |
title_full_unstemmed | Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection |
title_short | Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection |
title_sort | immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149372/ https://www.ncbi.nlm.nih.gov/pubmed/34095880 http://dx.doi.org/10.1016/j.xcrm.2021.100278 |
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