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Diverse immune response of DNA damage repair-deficient tumors

Tumors with DNA damage repair (DDR) deficiency accumulate genomic alterations that may serve as neoantigens and increase sensitivity to immune checkpoint inhibitor. However, over half of DDR-deficient tumors are refractory to immunotherapy, and it remains unclear which mutations may promote immunoge...

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Detalles Bibliográficos
Autores principales:	Qing, Tao, Jun, Tomi, Lindblad, Katherine E., Lujambio, Amaia, Marczyk, Michal, Pusztai, Lajos, Huang, Kuan-lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149377/ https://www.ncbi.nlm.nih.gov/pubmed/34095878 http://dx.doi.org/10.1016/j.xcrm.2021.100276

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