CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia

Internal tandem duplication (ITD) of FMS-like tyrosine kinase 3 (FLT3) confers poor prognosis and is found in approximately 25% of cases of acute myeloid leukemia (AML). Although FLT3 inhibitors have shown clinical benefit in patients with AML harboring FLT3-ITD, the therapeutic effect is limited. H...

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Detalles Bibliográficos
Autores principales: Karnan, Sivasundaram, Hanamura, Ichiro, Ota, Akinobu, Takasugi, Souichi, Nakamura, Ayano, Takahashi, Miyuki, Uchino, Kaori, Murakami, Satsuki, Wahiduzzaman, Md, Quang Vu, Lam, Rahman, Md Lutfur, Hasan, Muhammad Nazmul, Hyodo, Toshinori, Konishi, Hiroyuki, Tsuzuki, Shinobu, Yoshikawa, Kazuhiro, Suzuki, Susumu, Ueda, Ryuzo, Ejiri, Masayuki, Hosokawa, Yoshitaka, Takami, Akiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149417/
https://www.ncbi.nlm.nih.gov/pubmed/34035227
http://dx.doi.org/10.1038/s41420-021-00446-8

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