Cargando…

Modifying gut integrity and microbiome in children with severe acute malnutrition using legume-based feeds (MIMBLE): A pilot trial

Case fatality among African children with severe acute malnutrition remains high. We report a 3-arm pilot trial in 58 Ugandan children, comparing feeds targeting disordered gastrointestinal function containing cowpea (CpF, n = 20) or inulin (InF, n = 20) with conventional feeds (ConF, n = 18). Basel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Calder, Nuala, Walsh, Kevin, Olupot-Olupot, Peter, Ssenyondo, Tonny, Muhindo, Rita, Mpoya, Ayub, Brignardello, Jerusa, Wang, Xuedan, McKay, Eleanor, Morrison, Douglas, Holmes, Elaine, Frost, Gary, Maitland, Kathryn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149470/ https://www.ncbi.nlm.nih.gov/pubmed/34095882 http://dx.doi.org/10.1016/j.xcrm.2021.100280

Ejemplares similares

Modifying Intestinal Integrity and Micro Biome in Severe Malnutrition with Legume-Based Feeds (MIMBLE 2.0): protocol for a phase II refined feed and intervention trial
por: Walsh, Kevin, et al.
Publicado: (2018)

The clinical spectrum of severe childhood malaria in Eastern Uganda
por: Olupot-Olupot, Peter, et al.
Publicado: (2020)

Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): A Phase II Randomised Controlled trial: Trial Protocol
por: Olupot-Olupot, Peter, et al.
Publicado: (2021)

Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia
por: Olupot-Olupot, Peter, et al.
Publicado: (2014)

A Clinical and Physiological Prospective Observational Study on the Management of Pediatric Shock in the Post-Fluid Expansion as Supportive Therapy Trial Era
por: Obonyo, Nchafatso G., et al.
Publicado: (2022)

Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration
por: Houston, Kirsty A., et al.
Publicado: (2019)

Cardiovascular abnormalities in chest radiographs of children with pneumonia, Uganda
por: Nabawanuka, Eva, et al.
Publicado: (2023)

Gastroenteritis Aggressive Versus Slow Treatment For Rehydration (GASTRO). A pilot rehydration study for severe dehydration: WHO plan C versus slower rehydration
por: Houston, Kirsty A., et al.
Publicado: (2017)

Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial
por: Olupot-Olupot, Peter, et al.
Publicado: (2023)

Development of a legume-enriched feed for treatment of severe acute malnutrition
por: Walsh, Kevin, et al.
Publicado: (2023)

A predictive algorithm for identifying children with sickle cell anemia among children admitted to hospital with severe anemia in Africa
por: Olupot‐Olupot, Peter, et al.
Publicado: (2022)

Assessment of Myocardial Function and Injury by Echocardiography and Cardiac Biomarkers in African Children With Severe Plasmodium falciparum Malaria*
por: Kotlyar, Simon, et al.
Publicado: (2018)

Bacterial Aetiology and Antibiotic Susceptibility Profile of Post-Operative Sepsis among Surgical Patients in a Tertiary Hospital in Rural Eastern Uganda
por: George, Masifa, et al.
Publicado: (2018)

High false discovery rate of the Architect anti‐HCV screening test in blood donors in Uganda and evaluation of an algorithm for confirmatory testing
por: Lucey, Olivia, et al.
Publicado: (2022)

Children’s Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia
por: Maitland, Kathryn, et al.
Publicado: (2018)

Healthcare-provider perceptions of barriers to oxygen therapy for paediatric patients in three government-funded eastern Ugandan hospitals; a qualitative study
por: Dauncey, Jonathan W., et al.
Publicado: (2019)

Myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock (AFRIM study)
por: Obonyo, Nchafatso, et al.
Publicado: (2017)

Assessment of Myocardial Function in Kenyan Children With Severe, Acute Malnutrition: The Cardiac Physiology in Malnutrition (CAPMAL) Study
por: Brent, Bernadette, et al.
Publicado: (2019)

Haematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub‐Saharan Africa
por: Uyoga, Sophie, et al.
Publicado: (2019)

Mortality risk over time after early fluid resuscitation in African children
por: George, Elizabeth C., et al.
Publicado: (2019)

Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe anaemia in hospitalised children in Eastern Uganda
por: Olupot-Olupot, Peter, et al.
Publicado: (2019)

Increased adhesion of Plasmodium falciparum infected erythrocytes to ICAM-1 in children with acute intestinal injury
por: Church, James A., et al.
Publicado: (2016)

PARIST study protocol: a phase I/II randomised, controlled clinical trial to assess the feasibility, safety and effectiveness of paracetamol in resolving acute kidney injury in children with severe malaria
por: Paasi, George, et al.
Publicado: (2023)

Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score
por: George, Elizabeth C., et al.
Publicado: (2015)

Incidence and predictors of hospital readmission in children presenting with severe anaemia in Uganda and Malawi: a secondary analysis of TRACT trial data
por: Connon, Roisin, et al.
Publicado: (2021)

Was the “ABC” Approach (Abstinence, Being Faithful, Using Condoms) Responsible for Uganda's Decline in HIV?
por: Murphy, Elaine M, et al.
Publicado: (2006)

Health workers’ adherence to the malaria test, treat and track strategy during the COVID-19 pandemic in malaria high transmission area in Eastern Uganda
por: Mumali, Richard Kabaka, et al.
Publicado: (2023)

Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial
por: Maitland, Kathryn, et al.
Publicado: (2019)

‘The Words Will Pass with the Blowing Wind’: Staff and Parent Views of the Deferred Consent Process, with Prior Assent, Used in an Emergency Fluids Trial in Two African Hospitals
por: Molyneux, Sassy, et al.
Publicado: (2013)

Point-of-care haemoglobin testing in African hospitals: a neglected essential diagnostic test
por: Uyoga, Sophie, et al.
Publicado: (2021)

A study using knowledge, attitude and practices on the prevention of HIV-1 vertical transmission with outcomes in early infant HIV-1 diagnosis in Eastern Uganda
por: Nsubuga, Sydney, et al.
Publicado: (2019)

Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study
por: Byrne, Claire S, et al.
Publicado: (2019)

The frequency and severity of epistaxis in children with sickle cell anaemia in eastern Uganda: a case-control study
por: Nardo-Marino, Amina, et al.
Publicado: (2017)

The diagnostic upper GI endoscopy camp: a pilot for enhancing service provision and training in eastern Uganda
por: Doe, Matthew, et al.
Publicado: (2022)

Sickle cell anaemia and severe Plasmodium falciparum malaria: a secondary analysis of the Transfusion and Treatment of African Children Trial (TRACT)
por: Uyoga, Sophie, et al.
Publicado: (2022)

Asymptomatic Plasmodium Parasites among Adults in Eastern Uganda: A Case of Donor Blood Screening at Mbale Regional Blood Bank
por: Inyimai, Simon Peter, et al.
Publicado: (2018)

Severe malaria burden, clinical spectrum and outcomes at Apac district hospital, Uganda: a retrospective study of routine health facility-based data
por: Ocen, Emmanuel, et al.
Publicado: (2023)

Prevalence and Factors Associated With Cryptoccocal Antigenemia Among Patients With Advanced Human Immunodeficiency Virus in Eastern Uganda: A Facility-Based Cross-sectional Study
por: Eric, Ebonu, et al.
Publicado: (2023)

Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial
por: Mpoya, Ayub, et al.
Publicado: (2015)

Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia
por: Maitland, K., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3u7lavk5tdm2mud31lh1ni1tq7