Non-productive angiogenesis disassembles Aß plaque-associated blood vessels

The human Alzheimer’s disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around Aß plaques. Here we demonstrate that angiogenesis is started near Aß plaques in both AD mouse models and human AD samples. However, endothelial cells express the...

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Detalles Bibliográficos
Autores principales: Alvarez-Vergara, Maria I., Rosales-Nieves, Alicia E., March-Diaz, Rosana, Rodriguez-Perinan, Guiomar, Lara-Ureña, Nieves, Ortega-de San Luis, Clara, Sanchez-Garcia, Manuel A., Martin-Bornez, Miguel, Gómez-Gálvez, Pedro, Vicente-Munuera, Pablo, Fernandez-Gomez, Beatriz, Marchena, Miguel A., Bullones-Bolanos, Andrea S., Davila, Jose C., Gonzalez-Martinez, Rocio, Trillo-Contreras, Jose L., Sanchez-Hidalgo, Ana C., del Toro, Raquel, Scholl, Francisco G., Herrera, Eloisa, Trepel, Martin, Körbelin, Jakob, Escudero, Luis M., Villadiego, Javier, Echevarria, Miriam, de Castro, Fernando, Gutierrez, Antonia, Rabano, Alberto, Vitorica, Javier, Pascual, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149638/
https://www.ncbi.nlm.nih.gov/pubmed/34035282
http://dx.doi.org/10.1038/s41467-021-23337-z

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