Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson’s disease

Mitochondrial dysfunction and lysosomal dysfunction have been implicated in Parkinson’s disease (PD), but the links between these dysfunctions in PD pathogenesis are still largely unknown. Here we report that cytosolic dsDNA of mitochondrial origin escaping from lysosomal degradation was shown to in...

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Detalles Bibliográficos
Autores principales: Matsui, Hideaki, Ito, Junko, Matsui, Noriko, Uechi, Tamayo, Onodera, Osamu, Kakita, Akiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149644/
https://www.ncbi.nlm.nih.gov/pubmed/34035300
http://dx.doi.org/10.1038/s41467-021-23452-x

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