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Case Report: Changes of Vascular Reactivity and Arterial Stiffness in a Patient With Covid-19 Infection

Covid-19 infection may be associated with a higher incidence developing cardiovascular complications, however, the underlying mechanisms contributing to cardiovascular complications are largely unknown, while endothelial cell damage may be present. We want to report a 24-year-old woman with Covid-19...

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Autores principales: Jud, Philipp, Kessler, Harald H., Brodmann, Marianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149731/
https://www.ncbi.nlm.nih.gov/pubmed/34055940
http://dx.doi.org/10.3389/fcvm.2021.671669
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author Jud, Philipp
Kessler, Harald H.
Brodmann, Marianne
author_facet Jud, Philipp
Kessler, Harald H.
Brodmann, Marianne
author_sort Jud, Philipp
collection PubMed
description Covid-19 infection may be associated with a higher incidence developing cardiovascular complications, however, the underlying mechanisms contributing to cardiovascular complications are largely unknown, while endothelial cell damage may be present. We want to report a 24-year-old woman with Covid-19 infection who had undergone measurements of vascular reactivity and arterial stiffness, including flow-mediated dilation (FMD), nitroglycerin-mediated dilation (NMD), aortic pulse wave velocity (PWV), augmentation index and carotid intima-media-thickness (cIMT) at the time when Covid-19 was diagnosed. Reduced FMD of 0.0% and NMD of 15.5% were observed, while PWV (5.9 m/s), Aix (27%) and cIMT with 0.4 mm of both common carotid arteries were unremarkable. Repeated measurements of FMD, NMD, PWV, Aix, and cIMT 6 weeks after Covid-19 infection revealed persistently reduced FMD (0.0%), while NMD (17.24%), PWV (5.6 m/s) and augmentation index (13%) ameliorated. This case suggests potential impact of Covid-19 infection on endothelial function, also in young Covid-19 patients without any co-morbidity.
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spelling pubmed-81497312021-05-27 Case Report: Changes of Vascular Reactivity and Arterial Stiffness in a Patient With Covid-19 Infection Jud, Philipp Kessler, Harald H. Brodmann, Marianne Front Cardiovasc Med Cardiovascular Medicine Covid-19 infection may be associated with a higher incidence developing cardiovascular complications, however, the underlying mechanisms contributing to cardiovascular complications are largely unknown, while endothelial cell damage may be present. We want to report a 24-year-old woman with Covid-19 infection who had undergone measurements of vascular reactivity and arterial stiffness, including flow-mediated dilation (FMD), nitroglycerin-mediated dilation (NMD), aortic pulse wave velocity (PWV), augmentation index and carotid intima-media-thickness (cIMT) at the time when Covid-19 was diagnosed. Reduced FMD of 0.0% and NMD of 15.5% were observed, while PWV (5.9 m/s), Aix (27%) and cIMT with 0.4 mm of both common carotid arteries were unremarkable. Repeated measurements of FMD, NMD, PWV, Aix, and cIMT 6 weeks after Covid-19 infection revealed persistently reduced FMD (0.0%), while NMD (17.24%), PWV (5.6 m/s) and augmentation index (13%) ameliorated. This case suggests potential impact of Covid-19 infection on endothelial function, also in young Covid-19 patients without any co-morbidity. Frontiers Media S.A. 2021-05-12 /pmc/articles/PMC8149731/ /pubmed/34055940 http://dx.doi.org/10.3389/fcvm.2021.671669 Text en Copyright © 2021 Jud, Kessler and Brodmann. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Jud, Philipp
Kessler, Harald H.
Brodmann, Marianne
Case Report: Changes of Vascular Reactivity and Arterial Stiffness in a Patient With Covid-19 Infection
title Case Report: Changes of Vascular Reactivity and Arterial Stiffness in a Patient With Covid-19 Infection
title_full Case Report: Changes of Vascular Reactivity and Arterial Stiffness in a Patient With Covid-19 Infection
title_fullStr Case Report: Changes of Vascular Reactivity and Arterial Stiffness in a Patient With Covid-19 Infection
title_full_unstemmed Case Report: Changes of Vascular Reactivity and Arterial Stiffness in a Patient With Covid-19 Infection
title_short Case Report: Changes of Vascular Reactivity and Arterial Stiffness in a Patient With Covid-19 Infection
title_sort case report: changes of vascular reactivity and arterial stiffness in a patient with covid-19 infection
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149731/
https://www.ncbi.nlm.nih.gov/pubmed/34055940
http://dx.doi.org/10.3389/fcvm.2021.671669
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