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Case Report: Occupation Radiation Disease, Skin Injury, and Leukemia After Accidental Radiation Exposure

Objective: Follow-up observation of radiation accident in which a worker developed acute radiation disease and eventually died of leukemia. The case provided key practical information for the study on clinical effects of radiation on the health of workers. Case Presentation: We observed and followed...

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Autores principales: Hao, Xiaoji, Ye, Anfang, Yu, Shunfei, Ni, Qianying, Guo, Jiadi, Wang, Xiangguo, Gao, Shenyong, Lai, Zhongjun, Zhao, Yaoxian, Xuan, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149743/
https://www.ncbi.nlm.nih.gov/pubmed/34055721
http://dx.doi.org/10.3389/fpubh.2021.657564
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author Hao, Xiaoji
Ye, Anfang
Yu, Shunfei
Ni, Qianying
Guo, Jiadi
Wang, Xiangguo
Gao, Shenyong
Lai, Zhongjun
Zhao, Yaoxian
Xuan, Zhiqiang
author_facet Hao, Xiaoji
Ye, Anfang
Yu, Shunfei
Ni, Qianying
Guo, Jiadi
Wang, Xiangguo
Gao, Shenyong
Lai, Zhongjun
Zhao, Yaoxian
Xuan, Zhiqiang
author_sort Hao, Xiaoji
collection PubMed
description Objective: Follow-up observation of radiation accident in which a worker developed acute radiation disease and eventually died of leukemia. The case provided key practical information for the study on clinical effects of radiation on the health of workers. Case Presentation: We observed and followed-up the progression and effect of radiation exposure at various stages in a 28-year-old male patient. We examined the chromosomal morphology, white blood cell count, and sperm count. Laboratory tests for leukemia diagnosis and other clinical parameters were performed. Results: After the patient was irradiated, the white blood cell level decreased, the sperm count dropped to 0, and the libido completely disappeared. The patient's chromosome aberration cell rate and total chromosome aberration cell rate were 7.33 and 7.66%, respectively. Examination of leukemia diagnostic experiments revealed that abnormal cells accounted for 60%; bone marrow examination showed that prolymphocytes abnormally proliferated, accounting for 89%, and had positive extracellular iron staining. After the initial treatment, the patient's white blood cell level increased and was finally maintained at a normal level, the sperm count returned to normal levels, and libido was restored. The patient died of acute lymphoblastic leukemia 34 years after the exposure. Conclusion: More attention has been paid to the long-term effects of ionizing radiation-induced malignant tumors. The occupational protection of radiographic inspection workers should be strengthened to reduce and avoid occupational injuries to protect the health and safety of workers.
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spelling pubmed-81497432021-05-27 Case Report: Occupation Radiation Disease, Skin Injury, and Leukemia After Accidental Radiation Exposure Hao, Xiaoji Ye, Anfang Yu, Shunfei Ni, Qianying Guo, Jiadi Wang, Xiangguo Gao, Shenyong Lai, Zhongjun Zhao, Yaoxian Xuan, Zhiqiang Front Public Health Public Health Objective: Follow-up observation of radiation accident in which a worker developed acute radiation disease and eventually died of leukemia. The case provided key practical information for the study on clinical effects of radiation on the health of workers. Case Presentation: We observed and followed-up the progression and effect of radiation exposure at various stages in a 28-year-old male patient. We examined the chromosomal morphology, white blood cell count, and sperm count. Laboratory tests for leukemia diagnosis and other clinical parameters were performed. Results: After the patient was irradiated, the white blood cell level decreased, the sperm count dropped to 0, and the libido completely disappeared. The patient's chromosome aberration cell rate and total chromosome aberration cell rate were 7.33 and 7.66%, respectively. Examination of leukemia diagnostic experiments revealed that abnormal cells accounted for 60%; bone marrow examination showed that prolymphocytes abnormally proliferated, accounting for 89%, and had positive extracellular iron staining. After the initial treatment, the patient's white blood cell level increased and was finally maintained at a normal level, the sperm count returned to normal levels, and libido was restored. The patient died of acute lymphoblastic leukemia 34 years after the exposure. Conclusion: More attention has been paid to the long-term effects of ionizing radiation-induced malignant tumors. The occupational protection of radiographic inspection workers should be strengthened to reduce and avoid occupational injuries to protect the health and safety of workers. Frontiers Media S.A. 2021-05-12 /pmc/articles/PMC8149743/ /pubmed/34055721 http://dx.doi.org/10.3389/fpubh.2021.657564 Text en Copyright © 2021 Hao, Ye, Yu, Ni, Guo, Wang, Gao, Lai, Zhao and Xuan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Hao, Xiaoji
Ye, Anfang
Yu, Shunfei
Ni, Qianying
Guo, Jiadi
Wang, Xiangguo
Gao, Shenyong
Lai, Zhongjun
Zhao, Yaoxian
Xuan, Zhiqiang
Case Report: Occupation Radiation Disease, Skin Injury, and Leukemia After Accidental Radiation Exposure
title Case Report: Occupation Radiation Disease, Skin Injury, and Leukemia After Accidental Radiation Exposure
title_full Case Report: Occupation Radiation Disease, Skin Injury, and Leukemia After Accidental Radiation Exposure
title_fullStr Case Report: Occupation Radiation Disease, Skin Injury, and Leukemia After Accidental Radiation Exposure
title_full_unstemmed Case Report: Occupation Radiation Disease, Skin Injury, and Leukemia After Accidental Radiation Exposure
title_short Case Report: Occupation Radiation Disease, Skin Injury, and Leukemia After Accidental Radiation Exposure
title_sort case report: occupation radiation disease, skin injury, and leukemia after accidental radiation exposure
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149743/
https://www.ncbi.nlm.nih.gov/pubmed/34055721
http://dx.doi.org/10.3389/fpubh.2021.657564
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