Cargando…

JMJD6 Dysfunction Due to Iron Deficiency in Preeclampsia Disrupts Fibronectin Homeostasis Resulting in Diminished Trophoblast Migration

The mechanisms contributing to excessive fibronectin in preeclampsia, a pregnancy-related disorder, remain unknown. Herein, we investigated the role of JMJD6, an O(2)- and Fe(2+)-dependent enzyme, in mediating placental fibronectin processing and function. MALDI-TOF identified fibronectin as a novel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alahari, Sruthi, Farrell, Abby, Ermini, Leonardo, Park, Chanho, Sallais, Julien, Roberts, Sarah, Gillmore, Taylor, Litvack, Michael, Post, Martin, Caniggia, Isabella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149756/ https://www.ncbi.nlm.nih.gov/pubmed/34055782 http://dx.doi.org/10.3389/fcell.2021.652607

Ejemplares similares

Dichotomy in hypoxia-induced mitochondrial fission in placental mesenchymal cells during development and preeclampsia: consequences for trophoblast mitochondrial homeostasis
por: Gillmore, Taylor, et al.
Publicado: (2022)

Fibronectin and JMJD6 Signature in Circulating Placental Extracellular Vesicles for the Detection of Preeclampsia
por: Alahari, Sruthi, et al.
Publicado: (2023)

Ceramide-Induced Lysosomal Biogenesis and Exocytosis in Early-Onset Preeclampsia Promotes Exosomal Release of SMPD1 Causing Endothelial Dysfunction
por: Ermini, Leonardo, et al.
Publicado: (2021)

HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2
por: Sallais, Julien, et al.
Publicado: (2022)

Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis
por: Bailey, Liane Jennifer, et al.
Publicado: (2017)

Increased placental mitochondrial fusion in gestational diabetes mellitus: an adaptive mechanism to optimize feto-placental metabolic homeostasis?
por: Abbade, Joelcio, et al.
Publicado: (2020)

Factor inhibiting HIF1–A novel target of SUMOylation in the human placenta
por: Sallais, Julien, et al.
Publicado: (2017)

Distinct Changes in Placental Ceramide Metabolism Characterize Type 1 and 2 Diabetic Pregnancies with Fetal Macrosomia or Preeclampsia
por: Klemetti, Miira M., et al.
Publicado: (2023)

Ceramide-induced BOK promotes mitochondrial fission in preeclampsia
por: Ausman, Jonathan, et al.
Publicado: (2018)

A Single Sphingomyelin Species Promotes Exosomal Release of Endoglin into the Maternal Circulation in Preeclampsia
por: Ermini, Leonardo, et al.
Publicado: (2017)

The trophoblast survival capacity in preeclampsia
por: Hutabarat, Martina, et al.
Publicado: (2017)

Abnormalities in Oxygen Sensing Define Early and Late Onset Preeclampsia as Distinct Pathologies
por: Rolfo, Alessandro, et al.
Publicado: (2010)

Imaging mass spectrometry identifies prognostic ganglioside species in rodent intracranial transplants of glioma and medulloblastoma
por: Ermini, Leonardo, et al.
Publicado: (2017)

Disruption of Placental Homeostasis Leads to Preeclampsia
por: Nakashima, Akitoshi, et al.
Publicado: (2020)

TGFb1 suppresses the activation of distinct dNK subpopulations in preeclampsia
por: Zhang, Jianhong, et al.
Publicado: (2018)

Jmjd6 regulates ES cell homeostasis and enhances reprogramming efficiency()
por: Ji, Guanxu, et al.
Publicado: (2022)

Hypoxic stress disrupts HGF/Met signaling in human trophoblasts: implications for the pathogenesis of preeclampsia
por: Li, Guanlin, et al.
Publicado: (2022)

Aspirin Inhibits Fibronectin Expression and Reverses Fibronectin-Mediated Cell Invasiveness by Activating Akt Signaling in Preeclampsia
por: Su, Mei-Tsz, et al.
Publicado: (2022)

The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia
por: Huppertz, Berthold
Publicado: (2018)

CLDN1 regulates trophoblast apoptosis and proliferation in preeclampsia
por: Zhang, Yu-chen, et al.
Publicado: (2021)

Preeclampsia Is Associated with Alterations in the p53-Pathway in Villous Trophoblast
por: Sharp, Andrew N., et al.
Publicado: (2014)

Early onset preeclampsia in a model for human placental trophoblast
por: Sheridan, Megan A., et al.
Publicado: (2019)

Expression of SASH1 in Preeclampsia and Its Effects on Human Trophoblast
por: Liu, Shisan, et al.
Publicado: (2020)

The Novel Protease Activities of JMJD5–JMJD6–JMJD7 and Arginine Methylation Activities of Arginine Methyltransferases Are Likely Coupled
por: Liu, Haolin, et al.
Publicado: (2022)

Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7
por: Liu, Haolin, et al.
Publicado: (2018)

Preeclampsia: The Relationship between Uterine Artery Blood Flow and Trophoblast Function
por: Ridder, Anna, et al.
Publicado: (2019)

Role of LAMA4 Gene in Regulating Extravillous Trophoblasts in Pathogenesis of Preeclampsia
por: Ji, Yingli, et al.
Publicado: (2019)

Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms
por: Tan, Lunbo, et al.
Publicado: (2022)

TAGLN2-Regulated Trophoblast Migration, Invasion and Fusion are Impaired in Preeclampsia
por: Wang, Hao, et al.
Publicado: (2022)

Decreased IL-33 Production Contributes to Trophoblast Cell Dysfunction in Pregnancies with Preeclampsia
por: Chen, Hong, et al.
Publicado: (2018)

The metabolic role of LncZBTB39-1:2 in the trophoblast mobility of preeclampsia
por: Liu, Yamin, et al.
Publicado: (2018)

Impact of vitamin D and vitamin D receptor on the trophoblast survival capacity in preeclampsia
por: Hutabarat, Martina, et al.
Publicado: (2018)

Resveratrol Inhibits Trophoblast Apoptosis through Oxidative Stress in Preeclampsia-Model Rats
por: Zou, Yanfen, et al.
Publicado: (2014)

Trophoblast-Targeted Nanomedicine Modulates Placental sFLT1 for Preeclampsia Treatment
por: Li, Lei, et al.
Publicado: (2020)

Modelling preeclampsia: a comparative analysis of the common human trophoblast cell lines
por: Zhao, Jiawu, et al.
Publicado: (2020)

Role of lncRNA BCYRN1 in trophoblast cell physiology and pathogenesis of preeclampsia
por: Chen, Liping, et al.
Publicado: (2021)

Collagen I Induces Preeclampsia-Like Symptoms by Suppressing Proliferation and Invasion of Trophoblasts
por: Feng, Yinglin, et al.
Publicado: (2021)

The Mechanism of Downregulation of Twist1 Inhibiting Trophoblast Invasion and Aggravating the Development of Preeclampsia
por: Yang, Shuangjian, et al.
Publicado: (2022)

Preeclampsia is Associated With Reduced ISG15 Levels Impairing Extravillous Trophoblast Invasion
por: Ozmen, Asli, et al.
Publicado: (2022)

Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia
por: Tan, Lunbo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_1kumn9beasbi55vghm9fkvfvdb