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Copy number aberrations drive kinase rewiring, leading to genetic vulnerabilities in cancer

Somatic DNA copy number variations (CNVs) are prevalent in cancer and can drive cancer progression, albeit with often uncharacterized roles in altering cell signaling states. Here, we integrate genomic and proteomic data for 5,598 tumor samples to identify CNVs leading to aberrant signal transductio...

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Detalles Bibliográficos
Autores principales:	Memon, Danish, Gill, Michael B., Papachristou, Evangelia K., Ochoa, David, D’Santos, Clive S., Miller, Martin L., Beltrao, Pedro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149807/ https://www.ncbi.nlm.nih.gov/pubmed/34010657 http://dx.doi.org/10.1016/j.celrep.2021.109155

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