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Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

Circulating polymers of α1-antitrypsin (α1AT) are neutrophil chemo-attractants and contribute to inflammation, yet cellular factors affecting their secretion remain obscure. We report on a genome-wide CRISPR-Cas9 screen for genes affecting trafficking of polymerogenic α1AT(H334D). A CRISPR enrichmen...

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Detalles Bibliográficos
Autores principales:	Ordóñez, Adriana, Harding, Heather P., Marciniak, Stefan J., Ron, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149808/ https://www.ncbi.nlm.nih.gov/pubmed/34010647 http://dx.doi.org/10.1016/j.celrep.2021.109144

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