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Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs

Recent single-cell studies have revealed that yeast stress response involves transcription factors that are activated in pulses. However, it remains unclear whether and how these dynamic transcription factors temporally interact to regulate stress survival. Here we show that budding yeast cells can...

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Autores principales: Wu, Yan, Wu, Jiaqi, Deng, Minghua, Lin, Yihan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149833/
https://www.ncbi.nlm.nih.gov/pubmed/34035307
http://dx.doi.org/10.1038/s41467-021-23425-0
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author Wu, Yan
Wu, Jiaqi
Deng, Minghua
Lin, Yihan
author_facet Wu, Yan
Wu, Jiaqi
Deng, Minghua
Lin, Yihan
author_sort Wu, Yan
collection PubMed
description Recent single-cell studies have revealed that yeast stress response involves transcription factors that are activated in pulses. However, it remains unclear whether and how these dynamic transcription factors temporally interact to regulate stress survival. Here we show that budding yeast cells can exploit the temporal relationship between paralogous general stress regulators, Msn2 and Msn4, during stress response. We find that individual pulses of Msn2 and Msn4 are largely redundant, and cells can enhance the expression of their shared targets by increasing their temporal divergence. Thus, functional redundancy between these two paralogs is modulated in a dynamic manner to confer fitness advantages for yeast cells, which might feed back to promote the preservation of their redundancy. This evolutionary implication is supported by evidence from Msn2/Msn4 orthologs and analyses of other transcription factor paralogs. Together, we show a cell fate control mechanism through temporal redundancy modulation in yeast, which may represent an evolutionarily important strategy for maintaining functional redundancy between gene duplicates.
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spelling pubmed-81498332021-06-11 Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs Wu, Yan Wu, Jiaqi Deng, Minghua Lin, Yihan Nat Commun Article Recent single-cell studies have revealed that yeast stress response involves transcription factors that are activated in pulses. However, it remains unclear whether and how these dynamic transcription factors temporally interact to regulate stress survival. Here we show that budding yeast cells can exploit the temporal relationship between paralogous general stress regulators, Msn2 and Msn4, during stress response. We find that individual pulses of Msn2 and Msn4 are largely redundant, and cells can enhance the expression of their shared targets by increasing their temporal divergence. Thus, functional redundancy between these two paralogs is modulated in a dynamic manner to confer fitness advantages for yeast cells, which might feed back to promote the preservation of their redundancy. This evolutionary implication is supported by evidence from Msn2/Msn4 orthologs and analyses of other transcription factor paralogs. Together, we show a cell fate control mechanism through temporal redundancy modulation in yeast, which may represent an evolutionarily important strategy for maintaining functional redundancy between gene duplicates. Nature Publishing Group UK 2021-05-25 /pmc/articles/PMC8149833/ /pubmed/34035307 http://dx.doi.org/10.1038/s41467-021-23425-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wu, Yan
Wu, Jiaqi
Deng, Minghua
Lin, Yihan
Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs
title Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs
title_full Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs
title_fullStr Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs
title_full_unstemmed Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs
title_short Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs
title_sort yeast cell fate control by temporal redundancy modulation of transcription factor paralogs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149833/
https://www.ncbi.nlm.nih.gov/pubmed/34035307
http://dx.doi.org/10.1038/s41467-021-23425-0
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