INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer

INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P(2) to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is also a reported oncogene in other cancers. How these opposing INPP4B roles relate to PI3K regulation is unclear. We report PIK3CA-muta...

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Detalles Bibliográficos
Autores principales: Rodgers, Samuel J., Ooms, Lisa M., Oorschot, Viola M. J., Schittenhelm, Ralf B., Nguyen, Elizabeth V., Hamila, Sabryn A., Rynkiewicz, Natalie, Gurung, Rajendra, Eramo, Matthew J., Sriratana, Absorn, Fedele, Clare G., Caramia, Franco, Loi, Sherene, Kerr, Genevieve, Abud, Helen E., Ramm, Georg, Papa, Antonella, Ellisdon, Andrew M., Daly, Roger J., McLean, Catriona A., Mitchell, Christina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149851/
https://www.ncbi.nlm.nih.gov/pubmed/34035258
http://dx.doi.org/10.1038/s41467-021-23241-6

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