In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche

Short-term, systemic expression of the Yamanaka reprogramming factors (Oct-3/4, Sox2, Klf4 and c-Myc [OSKM]) has been shown to rejuvenate aging cells and promote tissue regeneration in vivo. However, the mechanisms by which OSKM promotes tissue regeneration are unknown. In this work, we focus on a s...

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Detalles Bibliográficos
Autores principales: Wang, Chao, Rabadan Ros, Ruben, Martinez-Redondo, Paloma, Ma, Zaijun, Shi, Lei, Xue, Yuan, Guillen-Guillen, Isabel, Huang, Ling, Hishida, Tomoaki, Liao, Hsin-Kai, Nuñez Delicado, Estrella, Rodriguez Esteban, Concepcion, Guillen-Garcia, Pedro, Reddy, Pradeep, Izpisua Belmonte, Juan Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149870/
https://www.ncbi.nlm.nih.gov/pubmed/34035273
http://dx.doi.org/10.1038/s41467-021-23353-z

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