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Association Between Metabolic Syndrome and Asymptomatic Cerebral Arterial Stenosis: A Cross-Sectional Study in Shandong, China

Metabolic syndrome (MetS) can worsen cerebral arterial atherosclerosis stenosis in patients with stroke; however, its effect on patients without stroke remains ambiguous. This study explored the association of MetS and its individual components with asymptomatic intracranial arterial stenosis (aICAS...

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Autores principales: Li, Shan, Sun, Xiao, Zhao, Yuanyuan, Wang, Xiang, Ji, Xiaokang, Sang, Shaowei, Shao, Sai, Xiang, Yuanyuan, Wang, Guangbin, Lv, Ming, Xue, Fuzhong, Sun, Qinjian, Du, Yifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149894/
https://www.ncbi.nlm.nih.gov/pubmed/34054693
http://dx.doi.org/10.3389/fneur.2021.644963
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author Li, Shan
Sun, Xiao
Zhao, Yuanyuan
Wang, Xiang
Ji, Xiaokang
Sang, Shaowei
Shao, Sai
Xiang, Yuanyuan
Wang, Guangbin
Lv, Ming
Xue, Fuzhong
Sun, Qinjian
Du, Yifeng
author_facet Li, Shan
Sun, Xiao
Zhao, Yuanyuan
Wang, Xiang
Ji, Xiaokang
Sang, Shaowei
Shao, Sai
Xiang, Yuanyuan
Wang, Guangbin
Lv, Ming
Xue, Fuzhong
Sun, Qinjian
Du, Yifeng
author_sort Li, Shan
collection PubMed
description Metabolic syndrome (MetS) can worsen cerebral arterial atherosclerosis stenosis in patients with stroke; however, its effect on patients without stroke remains ambiguous. This study explored the association of MetS and its individual components with asymptomatic intracranial arterial stenosis (aICAS) and asymptomatic extracranial arterial stenosis (aECAS) among older Chinese adults. A total of 1988 participants from the Kongcun Town study aged ≥40 years and without a history of stroke were enrolled. The baseline data were obtained via face-to-face interviews. MetS was defined according to International Diabetes Federation criteria. Detection of aICAS was conducted using transcranial Doppler ultrasound, followed by diagnosis via magnetic resonance angiography. The evaluation of aECAS was performed using bilateral carotid ultrasonography. The aICAS and aECAS groups were 1:1 matched separately to the non-stenosis group by age and sex. The association between MetS and aICAS or aECAS was analyzed using multivariate logistic regression. Among the 1988 participants, 909 were diagnosed with MetS. The prevalence of MetS was higher in the aICAS group than in the non-stenosis group (P <0.001), but did not differ significantly between the aECAS and non-stenosis groups. The prevalence of aICAS increased with the number of MetS components from 3.4% in the ≤ 1 component group to 12.7% in the ≥4 components group (P for trend <0.001). After adjusting for confounding factors, MetS components associated with aICAS included central obesity, elevated triglyceride levels, and elevated blood pressure. None of the MetS components was associated with aECAS. MetS was positively associated with aICAS, but not with aECAS. Further, different components play different roles in the pathological process leading to aICAS.
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spelling pubmed-81498942021-05-27 Association Between Metabolic Syndrome and Asymptomatic Cerebral Arterial Stenosis: A Cross-Sectional Study in Shandong, China Li, Shan Sun, Xiao Zhao, Yuanyuan Wang, Xiang Ji, Xiaokang Sang, Shaowei Shao, Sai Xiang, Yuanyuan Wang, Guangbin Lv, Ming Xue, Fuzhong Sun, Qinjian Du, Yifeng Front Neurol Neurology Metabolic syndrome (MetS) can worsen cerebral arterial atherosclerosis stenosis in patients with stroke; however, its effect on patients without stroke remains ambiguous. This study explored the association of MetS and its individual components with asymptomatic intracranial arterial stenosis (aICAS) and asymptomatic extracranial arterial stenosis (aECAS) among older Chinese adults. A total of 1988 participants from the Kongcun Town study aged ≥40 years and without a history of stroke were enrolled. The baseline data were obtained via face-to-face interviews. MetS was defined according to International Diabetes Federation criteria. Detection of aICAS was conducted using transcranial Doppler ultrasound, followed by diagnosis via magnetic resonance angiography. The evaluation of aECAS was performed using bilateral carotid ultrasonography. The aICAS and aECAS groups were 1:1 matched separately to the non-stenosis group by age and sex. The association between MetS and aICAS or aECAS was analyzed using multivariate logistic regression. Among the 1988 participants, 909 were diagnosed with MetS. The prevalence of MetS was higher in the aICAS group than in the non-stenosis group (P <0.001), but did not differ significantly between the aECAS and non-stenosis groups. The prevalence of aICAS increased with the number of MetS components from 3.4% in the ≤ 1 component group to 12.7% in the ≥4 components group (P for trend <0.001). After adjusting for confounding factors, MetS components associated with aICAS included central obesity, elevated triglyceride levels, and elevated blood pressure. None of the MetS components was associated with aECAS. MetS was positively associated with aICAS, but not with aECAS. Further, different components play different roles in the pathological process leading to aICAS. Frontiers Media S.A. 2021-05-12 /pmc/articles/PMC8149894/ /pubmed/34054693 http://dx.doi.org/10.3389/fneur.2021.644963 Text en Copyright © 2021 Li, Sun, Zhao, Wang, Ji, Sang, Shao, Xiang, Wang, Lv, Xue, Sun and Du. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Li, Shan
Sun, Xiao
Zhao, Yuanyuan
Wang, Xiang
Ji, Xiaokang
Sang, Shaowei
Shao, Sai
Xiang, Yuanyuan
Wang, Guangbin
Lv, Ming
Xue, Fuzhong
Sun, Qinjian
Du, Yifeng
Association Between Metabolic Syndrome and Asymptomatic Cerebral Arterial Stenosis: A Cross-Sectional Study in Shandong, China
title Association Between Metabolic Syndrome and Asymptomatic Cerebral Arterial Stenosis: A Cross-Sectional Study in Shandong, China
title_full Association Between Metabolic Syndrome and Asymptomatic Cerebral Arterial Stenosis: A Cross-Sectional Study in Shandong, China
title_fullStr Association Between Metabolic Syndrome and Asymptomatic Cerebral Arterial Stenosis: A Cross-Sectional Study in Shandong, China
title_full_unstemmed Association Between Metabolic Syndrome and Asymptomatic Cerebral Arterial Stenosis: A Cross-Sectional Study in Shandong, China
title_short Association Between Metabolic Syndrome and Asymptomatic Cerebral Arterial Stenosis: A Cross-Sectional Study in Shandong, China
title_sort association between metabolic syndrome and asymptomatic cerebral arterial stenosis: a cross-sectional study in shandong, china
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149894/
https://www.ncbi.nlm.nih.gov/pubmed/34054693
http://dx.doi.org/10.3389/fneur.2021.644963
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