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Cancer-Associated circRNA–miRNA–mRNA Regulatory Networks: A Meta-Analysis
Recent advances in sequencing technologies and the discovery of non-coding RNAs (ncRNAs) have provided new insights in the molecular pathogenesis of cancers. Several studies have implicated the role of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and recently discovered circ...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149909/ https://www.ncbi.nlm.nih.gov/pubmed/34055888 http://dx.doi.org/10.3389/fmolb.2021.671309 |
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author | Khan, Shaheerah Jha, Atimukta Panda, Amaresh C. Dixit, Anshuman |
author_facet | Khan, Shaheerah Jha, Atimukta Panda, Amaresh C. Dixit, Anshuman |
author_sort | Khan, Shaheerah |
collection | PubMed |
description | Recent advances in sequencing technologies and the discovery of non-coding RNAs (ncRNAs) have provided new insights in the molecular pathogenesis of cancers. Several studies have implicated the role of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and recently discovered circular RNAs (circRNAs) in tumorigenesis and metastasis. Unlike linear RNAs, circRNAs are highly stable and closed-loop RNA molecules. It has been established that circRNAs regulate gene expression by controlling the functions of miRNAs and RNA-binding protein (RBP) or by translating into proteins. The circRNA–miRNA–mRNA regulatory axis is associated with human diseases, such as cancers, Alzheimer’s disease, and diabetes. In this study, we explored the interaction among circRNAs, miRNAs, and their target genes in various cancers using state-of-the-art bioinformatics tools. We identified differentially expressed circRNAs, miRNAs, and mRNAs on multiple cancers from publicly available data. Furthermore, we identified many crucial drivers and tumor suppressor genes in the circRNA–miRNA–mRNA regulatory axis in various cancers. Together, this study data provide a deeper understanding of the circRNA–miRNA–mRNA regulatory mechanisms in cancers. |
format | Online Article Text |
id | pubmed-8149909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81499092021-05-27 Cancer-Associated circRNA–miRNA–mRNA Regulatory Networks: A Meta-Analysis Khan, Shaheerah Jha, Atimukta Panda, Amaresh C. Dixit, Anshuman Front Mol Biosci Molecular Biosciences Recent advances in sequencing technologies and the discovery of non-coding RNAs (ncRNAs) have provided new insights in the molecular pathogenesis of cancers. Several studies have implicated the role of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and recently discovered circular RNAs (circRNAs) in tumorigenesis and metastasis. Unlike linear RNAs, circRNAs are highly stable and closed-loop RNA molecules. It has been established that circRNAs regulate gene expression by controlling the functions of miRNAs and RNA-binding protein (RBP) or by translating into proteins. The circRNA–miRNA–mRNA regulatory axis is associated with human diseases, such as cancers, Alzheimer’s disease, and diabetes. In this study, we explored the interaction among circRNAs, miRNAs, and their target genes in various cancers using state-of-the-art bioinformatics tools. We identified differentially expressed circRNAs, miRNAs, and mRNAs on multiple cancers from publicly available data. Furthermore, we identified many crucial drivers and tumor suppressor genes in the circRNA–miRNA–mRNA regulatory axis in various cancers. Together, this study data provide a deeper understanding of the circRNA–miRNA–mRNA regulatory mechanisms in cancers. Frontiers Media S.A. 2021-05-12 /pmc/articles/PMC8149909/ /pubmed/34055888 http://dx.doi.org/10.3389/fmolb.2021.671309 Text en Copyright © 2021 Khan, Jha, Panda and Dixit. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Khan, Shaheerah Jha, Atimukta Panda, Amaresh C. Dixit, Anshuman Cancer-Associated circRNA–miRNA–mRNA Regulatory Networks: A Meta-Analysis |
title | Cancer-Associated circRNA–miRNA–mRNA Regulatory Networks: A Meta-Analysis |
title_full | Cancer-Associated circRNA–miRNA–mRNA Regulatory Networks: A Meta-Analysis |
title_fullStr | Cancer-Associated circRNA–miRNA–mRNA Regulatory Networks: A Meta-Analysis |
title_full_unstemmed | Cancer-Associated circRNA–miRNA–mRNA Regulatory Networks: A Meta-Analysis |
title_short | Cancer-Associated circRNA–miRNA–mRNA Regulatory Networks: A Meta-Analysis |
title_sort | cancer-associated circrna–mirna–mrna regulatory networks: a meta-analysis |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149909/ https://www.ncbi.nlm.nih.gov/pubmed/34055888 http://dx.doi.org/10.3389/fmolb.2021.671309 |
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