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Longitudinal assessment of SARS-CoV-2 IgG seroconversionamong front-line healthcare workers during the first wave of the Covid-19 pandemic at a tertiary-care hospital in Chile

BACKGROUND: Healthcare workers (HCWs) are at high risk of exposure to SARS-CoV-2. Cross-sectional studies have provided variable rates of seroprevalence in HCWs. Longitudinal assessments of the serological response to Covid-19 among HCWs are crucial to understanding the risk of infection and changes...

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Autores principales: Iruretagoyena, Mirentxu, Vial, Macarena R., Spencer-Sandino, Maria, Gaete, Pablo, Peters, Anne, Delgado, Iris, Perez, Inia, Calderon, Claudia, Porte, Lorena, Legarraga, Paulette, Anderson, Alicia, Aguilera, Ximena, Vial, Pablo, Weitzel, Thomas, Munita, Jose M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149923/
https://www.ncbi.nlm.nih.gov/pubmed/34039287
http://dx.doi.org/10.1186/s12879-021-06208-2
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author Iruretagoyena, Mirentxu
Vial, Macarena R.
Spencer-Sandino, Maria
Gaete, Pablo
Peters, Anne
Delgado, Iris
Perez, Inia
Calderon, Claudia
Porte, Lorena
Legarraga, Paulette
Anderson, Alicia
Aguilera, Ximena
Vial, Pablo
Weitzel, Thomas
Munita, Jose M.
author_facet Iruretagoyena, Mirentxu
Vial, Macarena R.
Spencer-Sandino, Maria
Gaete, Pablo
Peters, Anne
Delgado, Iris
Perez, Inia
Calderon, Claudia
Porte, Lorena
Legarraga, Paulette
Anderson, Alicia
Aguilera, Ximena
Vial, Pablo
Weitzel, Thomas
Munita, Jose M.
author_sort Iruretagoyena, Mirentxu
collection PubMed
description BACKGROUND: Healthcare workers (HCWs) are at high risk of exposure to SARS-CoV-2. Cross-sectional studies have provided variable rates of seroprevalence in HCWs. Longitudinal assessments of the serological response to Covid-19 among HCWs are crucial to understanding the risk of infection and changes in antibody titers over time. We aimed to investigate seroprevalence and risk factors associated with seroconversion in a prospective cohort of HCWs during the peak of the first wave of the Covid-19 pandemic. METHODS: We conducted a longitudinal study among 446 front-line HCWsin a tertiary-care hospital in Chile from April to July 2020. IgG was determined monthly using two different ELISAs in serum samples of HCWs, during the three-month period. In each visit, demographic data, symptoms, risk factors, and exposure risks were also assessed. RESULTS: The overall seroprevalence at the end of the study period was 24% (95% CI20.2–28.3), with 43% of seropositive HCWs reporting no prior symptoms. Seroconversion rates significantly differed over the study period, from 2.1% to as high as 8.8% at the peak of the epidemic. There were no statistically significant differences observed between HCWs in direct clinical care of patients with Covid-19 and those working in low risk areas. Antibody titers appeared to wane over time. CONCLUSIONS: HCWs were severely affected with a high rate of seroconversion that appeared to mirror the local epidemiological situation. A significant amount of participants underwent an asymptomatic infection, highlighting the need for improved surveillance policies. Antibody titers appear to wane over time; further studies to understand this finding’s impact on the risk of reinfection are warranted. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-021-06208-2.
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spelling pubmed-81499232021-05-26 Longitudinal assessment of SARS-CoV-2 IgG seroconversionamong front-line healthcare workers during the first wave of the Covid-19 pandemic at a tertiary-care hospital in Chile Iruretagoyena, Mirentxu Vial, Macarena R. Spencer-Sandino, Maria Gaete, Pablo Peters, Anne Delgado, Iris Perez, Inia Calderon, Claudia Porte, Lorena Legarraga, Paulette Anderson, Alicia Aguilera, Ximena Vial, Pablo Weitzel, Thomas Munita, Jose M. BMC Infect Dis Research BACKGROUND: Healthcare workers (HCWs) are at high risk of exposure to SARS-CoV-2. Cross-sectional studies have provided variable rates of seroprevalence in HCWs. Longitudinal assessments of the serological response to Covid-19 among HCWs are crucial to understanding the risk of infection and changes in antibody titers over time. We aimed to investigate seroprevalence and risk factors associated with seroconversion in a prospective cohort of HCWs during the peak of the first wave of the Covid-19 pandemic. METHODS: We conducted a longitudinal study among 446 front-line HCWsin a tertiary-care hospital in Chile from April to July 2020. IgG was determined monthly using two different ELISAs in serum samples of HCWs, during the three-month period. In each visit, demographic data, symptoms, risk factors, and exposure risks were also assessed. RESULTS: The overall seroprevalence at the end of the study period was 24% (95% CI20.2–28.3), with 43% of seropositive HCWs reporting no prior symptoms. Seroconversion rates significantly differed over the study period, from 2.1% to as high as 8.8% at the peak of the epidemic. There were no statistically significant differences observed between HCWs in direct clinical care of patients with Covid-19 and those working in low risk areas. Antibody titers appeared to wane over time. CONCLUSIONS: HCWs were severely affected with a high rate of seroconversion that appeared to mirror the local epidemiological situation. A significant amount of participants underwent an asymptomatic infection, highlighting the need for improved surveillance policies. Antibody titers appear to wane over time; further studies to understand this finding’s impact on the risk of reinfection are warranted. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-021-06208-2. BioMed Central 2021-05-26 /pmc/articles/PMC8149923/ /pubmed/34039287 http://dx.doi.org/10.1186/s12879-021-06208-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Iruretagoyena, Mirentxu
Vial, Macarena R.
Spencer-Sandino, Maria
Gaete, Pablo
Peters, Anne
Delgado, Iris
Perez, Inia
Calderon, Claudia
Porte, Lorena
Legarraga, Paulette
Anderson, Alicia
Aguilera, Ximena
Vial, Pablo
Weitzel, Thomas
Munita, Jose M.
Longitudinal assessment of SARS-CoV-2 IgG seroconversionamong front-line healthcare workers during the first wave of the Covid-19 pandemic at a tertiary-care hospital in Chile
title Longitudinal assessment of SARS-CoV-2 IgG seroconversionamong front-line healthcare workers during the first wave of the Covid-19 pandemic at a tertiary-care hospital in Chile
title_full Longitudinal assessment of SARS-CoV-2 IgG seroconversionamong front-line healthcare workers during the first wave of the Covid-19 pandemic at a tertiary-care hospital in Chile
title_fullStr Longitudinal assessment of SARS-CoV-2 IgG seroconversionamong front-line healthcare workers during the first wave of the Covid-19 pandemic at a tertiary-care hospital in Chile
title_full_unstemmed Longitudinal assessment of SARS-CoV-2 IgG seroconversionamong front-line healthcare workers during the first wave of the Covid-19 pandemic at a tertiary-care hospital in Chile
title_short Longitudinal assessment of SARS-CoV-2 IgG seroconversionamong front-line healthcare workers during the first wave of the Covid-19 pandemic at a tertiary-care hospital in Chile
title_sort longitudinal assessment of sars-cov-2 igg seroconversionamong front-line healthcare workers during the first wave of the covid-19 pandemic at a tertiary-care hospital in chile
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149923/
https://www.ncbi.nlm.nih.gov/pubmed/34039287
http://dx.doi.org/10.1186/s12879-021-06208-2
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