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Agarose, Alginate and Chitosan Nanostructured Aerogels for Pharmaceutical Applications: A Short Review

In this short review, drug delivery systems, formed by polysaccharide-based (i.e., agarose, alginate, and chitosan) aerogels, are analyzed. In particular, the main papers, published in the period 2011–2020 in this research field, have been investigated and critically discussed, in order to highlight...

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Autores principales: Guastaferro, Mariangela, Reverchon, Ernesto, Baldino, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149959/
https://www.ncbi.nlm.nih.gov/pubmed/34055766
http://dx.doi.org/10.3389/fbioe.2021.688477
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author Guastaferro, Mariangela
Reverchon, Ernesto
Baldino, Lucia
author_facet Guastaferro, Mariangela
Reverchon, Ernesto
Baldino, Lucia
author_sort Guastaferro, Mariangela
collection PubMed
description In this short review, drug delivery systems, formed by polysaccharide-based (i.e., agarose, alginate, and chitosan) aerogels, are analyzed. In particular, the main papers, published in the period 2011–2020 in this research field, have been investigated and critically discussed, in order to highlight strengths and weaknesses of the traditional production techniques (e.g., freeze-drying and air evaporation) of bio-aerogels with respect to supercritical CO(2) assisted drying. Supercritical CO(2) assisted drying demonstrated to be a promising technique to produce nanostructured bio-aerogels that maintain the starting gel volume and shape, when the solvent removal occurs at negligible surface tension. This characteristic, coupled with the possibility of removing also cross-linking agent residues from the aerogels, makes these advanced devices safe and suitable as carriers for controlled drug delivery applications.
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spelling pubmed-81499592021-05-27 Agarose, Alginate and Chitosan Nanostructured Aerogels for Pharmaceutical Applications: A Short Review Guastaferro, Mariangela Reverchon, Ernesto Baldino, Lucia Front Bioeng Biotechnol Bioengineering and Biotechnology In this short review, drug delivery systems, formed by polysaccharide-based (i.e., agarose, alginate, and chitosan) aerogels, are analyzed. In particular, the main papers, published in the period 2011–2020 in this research field, have been investigated and critically discussed, in order to highlight strengths and weaknesses of the traditional production techniques (e.g., freeze-drying and air evaporation) of bio-aerogels with respect to supercritical CO(2) assisted drying. Supercritical CO(2) assisted drying demonstrated to be a promising technique to produce nanostructured bio-aerogels that maintain the starting gel volume and shape, when the solvent removal occurs at negligible surface tension. This characteristic, coupled with the possibility of removing also cross-linking agent residues from the aerogels, makes these advanced devices safe and suitable as carriers for controlled drug delivery applications. Frontiers Media S.A. 2021-05-12 /pmc/articles/PMC8149959/ /pubmed/34055766 http://dx.doi.org/10.3389/fbioe.2021.688477 Text en Copyright © 2021 Guastaferro, Reverchon and Baldino. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Guastaferro, Mariangela
Reverchon, Ernesto
Baldino, Lucia
Agarose, Alginate and Chitosan Nanostructured Aerogels for Pharmaceutical Applications: A Short Review
title Agarose, Alginate and Chitosan Nanostructured Aerogels for Pharmaceutical Applications: A Short Review
title_full Agarose, Alginate and Chitosan Nanostructured Aerogels for Pharmaceutical Applications: A Short Review
title_fullStr Agarose, Alginate and Chitosan Nanostructured Aerogels for Pharmaceutical Applications: A Short Review
title_full_unstemmed Agarose, Alginate and Chitosan Nanostructured Aerogels for Pharmaceutical Applications: A Short Review
title_short Agarose, Alginate and Chitosan Nanostructured Aerogels for Pharmaceutical Applications: A Short Review
title_sort agarose, alginate and chitosan nanostructured aerogels for pharmaceutical applications: a short review
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149959/
https://www.ncbi.nlm.nih.gov/pubmed/34055766
http://dx.doi.org/10.3389/fbioe.2021.688477
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