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The inherent flexibility of type I non-ribosomal peptide synthetase multienzymes drives their catalytic activities

Non-ribosomal peptide synthetases (NRPSs) are multienzymes that produce complex natural metabolites with many applications in medicine and agriculture. They are composed of numerous catalytic domains that elongate and chemically modify amino acid substrates or derivatives and of non-catalytic carrie...

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Detalles Bibliográficos
Autores principales: Bonhomme, Sarah, Dessen, Andréa, Macheboeuf, Pauline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150014/
https://www.ncbi.nlm.nih.gov/pubmed/34034506
http://dx.doi.org/10.1098/rsob.200386