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The inherent flexibility of type I non-ribosomal peptide synthetase multienzymes drives their catalytic activities
Non-ribosomal peptide synthetases (NRPSs) are multienzymes that produce complex natural metabolites with many applications in medicine and agriculture. They are composed of numerous catalytic domains that elongate and chemically modify amino acid substrates or derivatives and of non-catalytic carrie...
Autores principales: | Bonhomme, Sarah, Dessen, Andréa, Macheboeuf, Pauline |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150014/ https://www.ncbi.nlm.nih.gov/pubmed/34034506 http://dx.doi.org/10.1098/rsob.200386 |
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