Coordinating bioorthogonal reactions with two tumor-microenvironment-responsive nanovehicles for spatiotemporally controlled prodrug activation

Precise activation of prodrugs in tumor tissues is critical to ensuring specific antitumor efficacy, meanwhile reducing the serious adverse effects. Here, a spatiotemporally controlled prodrug activation strategy was provided by integrating the inverse electron demand Diels–Alder (IEDDA) reaction wi...

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Detalles Bibliográficos
Autores principales: Zuo, Liping, Ding, Jingjing, Li, Changkun, Lin, Feng, Chen, Peng R., Wang, Peilin, Lu, Guihong, Zhang, Jinfeng, Huang, Li-Li, Xie, Hai-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150104/
https://www.ncbi.nlm.nih.gov/pubmed/34123305
http://dx.doi.org/10.1039/c9sc05036a

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