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Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation
Background: Four-dimensional (4D) flow cardiovascular magnetic resonance imaging (MRI) is an emerging technique used for intra-cardiac blood flow assessment. The role of 4D flow cardiovascular MRI in the assessment of trans-valvular flow in patients with atrial fibrillation (AF) has not previously b...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150120/ https://www.ncbi.nlm.nih.gov/pubmed/34095509 http://dx.doi.org/10.12688/wellcomeopenres.16655.2 |
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author | Mills, Mark T Grafton-Clarke, Ciaran Williams, Gareth Gosling, Rebecca C Al Baraikan, Abdulaziz Kyriacou, Andreas L Morris, Paul D Gunn, Julian P Swoboda, Peter P Levelt, Eylem Tsampasian, Vasiliki van der Geest, Rob J Swift, Andrew J Greenwood, John P Plein, Sven Vassiliou, Vass Garg, Pankaj |
author_facet | Mills, Mark T Grafton-Clarke, Ciaran Williams, Gareth Gosling, Rebecca C Al Baraikan, Abdulaziz Kyriacou, Andreas L Morris, Paul D Gunn, Julian P Swoboda, Peter P Levelt, Eylem Tsampasian, Vasiliki van der Geest, Rob J Swift, Andrew J Greenwood, John P Plein, Sven Vassiliou, Vass Garg, Pankaj |
author_sort | Mills, Mark T |
collection | PubMed |
description | Background: Four-dimensional (4D) flow cardiovascular magnetic resonance imaging (MRI) is an emerging technique used for intra-cardiac blood flow assessment. The role of 4D flow cardiovascular MRI in the assessment of trans-valvular flow in patients with atrial fibrillation (AF) has not previously been assessed. The purpose of this study was to assess the feasibility, image quality, and internal validity of 4D flow cardiovascular MRI in the quantification of trans-valvular flow in patients with AF. Methods: Patients with AF and healthy controls in sinus rhythm underwent cardiovascular MRI, including 4D flow studies. Quality assurance checks were done on the raw data and streamlines. Consistency was investigated by trans-valvular flow assessment between the mitral valve (MV) and the aortic valve (AV). Results: Eight patients with AF (88% male, mean age 62±13 years, mean heart rate (HR) 83±16 beats per minute (bpm)) were included and compared with ten healthy controls (70% male, mean age 41±20 years, mean HR 68.5±9 bpm). All scans were of either good quality with minimal blurring artefacts, or excellent quality with no artefacts. No significant bias was observed between the AV and MV stroke volumes in either healthy controls (–4.8, 95% CI –15.64 to 6.04; P=0.34) or in patients with AF (1.64, 95% CI –4.7 to 7.94; P=0.56). A significant correlation was demonstrated between MV and AV stroke volumes in both healthy controls (r=0.87, 95% CI 0.52 to 0.97; P=0.001) and in AF patients (r=0.82, 95% CI 0.26 to 0.97; P=0.01). Conclusions: In patients with AF, 4D flow cardiovascular MRI is feasible with good image quality, allowing for quantification of trans-valvular flow. |
format | Online Article Text |
id | pubmed-8150120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-81501202021-06-04 Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation Mills, Mark T Grafton-Clarke, Ciaran Williams, Gareth Gosling, Rebecca C Al Baraikan, Abdulaziz Kyriacou, Andreas L Morris, Paul D Gunn, Julian P Swoboda, Peter P Levelt, Eylem Tsampasian, Vasiliki van der Geest, Rob J Swift, Andrew J Greenwood, John P Plein, Sven Vassiliou, Vass Garg, Pankaj Wellcome Open Res Research Article Background: Four-dimensional (4D) flow cardiovascular magnetic resonance imaging (MRI) is an emerging technique used for intra-cardiac blood flow assessment. The role of 4D flow cardiovascular MRI in the assessment of trans-valvular flow in patients with atrial fibrillation (AF) has not previously been assessed. The purpose of this study was to assess the feasibility, image quality, and internal validity of 4D flow cardiovascular MRI in the quantification of trans-valvular flow in patients with AF. Methods: Patients with AF and healthy controls in sinus rhythm underwent cardiovascular MRI, including 4D flow studies. Quality assurance checks were done on the raw data and streamlines. Consistency was investigated by trans-valvular flow assessment between the mitral valve (MV) and the aortic valve (AV). Results: Eight patients with AF (88% male, mean age 62±13 years, mean heart rate (HR) 83±16 beats per minute (bpm)) were included and compared with ten healthy controls (70% male, mean age 41±20 years, mean HR 68.5±9 bpm). All scans were of either good quality with minimal blurring artefacts, or excellent quality with no artefacts. No significant bias was observed between the AV and MV stroke volumes in either healthy controls (–4.8, 95% CI –15.64 to 6.04; P=0.34) or in patients with AF (1.64, 95% CI –4.7 to 7.94; P=0.56). A significant correlation was demonstrated between MV and AV stroke volumes in both healthy controls (r=0.87, 95% CI 0.52 to 0.97; P=0.001) and in AF patients (r=0.82, 95% CI 0.26 to 0.97; P=0.01). Conclusions: In patients with AF, 4D flow cardiovascular MRI is feasible with good image quality, allowing for quantification of trans-valvular flow. F1000 Research Limited 2021-05-18 /pmc/articles/PMC8150120/ /pubmed/34095509 http://dx.doi.org/10.12688/wellcomeopenres.16655.2 Text en Copyright: © 2021 Mills MT et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Mills, Mark T Grafton-Clarke, Ciaran Williams, Gareth Gosling, Rebecca C Al Baraikan, Abdulaziz Kyriacou, Andreas L Morris, Paul D Gunn, Julian P Swoboda, Peter P Levelt, Eylem Tsampasian, Vasiliki van der Geest, Rob J Swift, Andrew J Greenwood, John P Plein, Sven Vassiliou, Vass Garg, Pankaj Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation |
title | Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation |
title_full | Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation |
title_fullStr | Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation |
title_full_unstemmed | Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation |
title_short | Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation |
title_sort | feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150120/ https://www.ncbi.nlm.nih.gov/pubmed/34095509 http://dx.doi.org/10.12688/wellcomeopenres.16655.2 |
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