Cargando…

Phase II (NAVIGATE-AD study) Results of LY3202626 Effects on Patients with Mild Alzheimer’s Disease Dementia

BACKGROUND: LY3202626 is a small molecule inhibitor of β-site amyloid precursor protein cleaving enzyme (BACE)1 shown to reduce amyloid-β (Aβ)(1–40) and Aβ(1–42) concentrations in plasma and cerebrospinal fluid developed for the treatment of Alzheimer’s disease (AD). OBJECTIVE: To assess the change...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lo, Albert C., Evans, Cynthia Duggan, Mancini, Michele, Wang, Hong, Shcherbinin, Sergey, Lu, Ming, Natanegara, Fanni, Willis, Brian A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2021
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150257/ https://www.ncbi.nlm.nih.gov/pubmed/34113788 http://dx.doi.org/10.3233/ADR-210296

Ejemplares similares

Donanemab (LY3002813) dose‐escalation study in Alzheimer's disease
por: Lowe, Stephen Loucian, et al.
Publicado: (2021)

Robust Pharmacodynamic Effect of LY3202626, a Central Nervous System Penetrant, Low Dose BACE1 Inhibitor, in Humans and Nonclinical Species
por: Willis, Brian A., et al.
Publicado: (2022)

Magnetic resonance imaging measures of brain volumes across the EXPEDITION trials in mild and moderate Alzheimer's disease dementia
por: Svaldi, Diana Otero, et al.
Publicado: (2022)

Central pharmacodynamic activity of solanezumab in mild Alzheimer's disease dementia
por: Willis, Brian A., et al.
Publicado: (2018)

A multicentre longitudinal study of flortaucipir ((18)F) in normal ageing, mild cognitive impairment and Alzheimer’s disease dementia
por: Pontecorvo, Michael J, et al.
Publicado: (2019)

Disease progression modelling from preclinical Alzheimer’s disease (AD) to AD dementia
por: Cho, Soo Hyun, et al.
Publicado: (2021)

Patterns of use of symptomatic treatments for Alzheimer's disease dementia (AD)
por: DiBello, Julia R., et al.
Publicado: (2023)

Cognitive Blackouts in Mild Cognitive Impairment and Alzheimer's Dementia
por: Adler, Georg, et al.
Publicado: (2018)

The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals
por: Dickerson, Bradford C., et al.
Publicado: (2009)

Neural Correlates of Spatial Navigation Changes in Mild Cognitive Impairment and Alzheimer’s Disease
por: Vlček, Kamil, et al.
Publicado: (2014)

Safety, Tolerability, and Pharmacokinetics of Zagotenemab in Participants with Symptomatic Alzheimer’s Disease: A Phase I Clinical Trial
por: Willis, Brian A., et al.
Publicado: (2023)

Landmark Recognition in Alzheimer’s Dementia: Spared Implicit Memory for Objects Relevant for Navigation
por: Kessels, Roy P. C., et al.
Publicado: (2011)

Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome
por: Luo, Linlin, et al.
Publicado: (2016)

Comparing Cognitive Profiles of Licensed Drivers with Mild Alzheimer's Disease and Mild Dementia with Lewy Bodies
por: Yamin, Stephanie, et al.
Publicado: (2016)

Donanemab exposure and efficacy relationship using modeling in Alzheimer's disease
por: Gueorguieva, Ivelina, et al.
Publicado: (2023)

Measuring emotion recognition: Added value in diagnosing dementia of the Alzheimer’s disease type
por: Strijkert, Fijanne, et al.
Publicado: (2021)

IDE Gene Polymorphism Influences on BPSD in Mild Dementia of Alzheimer's Type
por: Sato, Noriko, et al.
Publicado: (2008)

P300 and Neuropsychological Assessment in Mild Cognitive Impairment and Alzheimer Dementia
por: Parra, Mario A., et al.
Publicado: (2012)

Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease
por: Sweeney, Melanie D, et al.
Publicado: (2015)

Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer's Type Dementia
por: Bulut, Mehmet, et al.
Publicado: (2016)

The MMSE should not be the sole indicator of fitness to drive in mild Alzheimer’s dementia
por: Piersma, D., et al.
Publicado: (2018)

Disclosing genetic risk for Alzheimer's dementia to individuals with mild cognitive impairment
por: Christensen, Kurt D., et al.
Publicado: (2020)

Safety and tolerability of GRF6019 in mild‐to‐moderate Alzheimer's disease dementia
por: Hannestad, Jonas, et al.
Publicado: (2020)

Progression to Dementia in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease
por: Hamilton, Calum A., et al.
Publicado: (2021)

Deep Brain Stimulation: A Potential Treatment for Dementia in Alzheimer's Disease (AD) and Parkinson's Disease Dementia (PDD)
por: Lv, Qing, et al.
Publicado: (2018)

Reduced Sympathetic Response to Head-Up Tilt in Subjects with Mild Cognitive Impairment or Mild Alzheimer's Dementia
por: Mellingsæter, Marte Rognstad, et al.
Publicado: (2015)

The Human Brain Representation of Odor Identification in Amnestic Mild Cognitive Impairment and Alzheimer's Dementia of Mild Degree
por: Kjelvik, Grete, et al.
Publicado: (2021)

Neuroinflammation, AD, and Dementia
por: Reale, Marcella, et al.
Publicado: (2010)

Developmental and communicative interrelations of Ly123 and Ly1 cell sets
Publicado: (1980)

Neces-SARI-ly?
por: Martin-Loeches, Ignacio, et al.
Publicado: (2016)

Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia()
por: La Joie, Renaud, et al.
Publicado: (2013)

Perception of emotions in mild cognitive impairment and Alzheimer’s dementia: does intensity matter?
por: Elferink, Maaike Waanders-Oude, et al.
Publicado: (2015)

Comment on “Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer's Type Dementia”
por: Ilhan, Abdullah, et al.
Publicado: (2016)

Cognitive Profiles of Patients with Mild Cognitive Impairment or Dementia in Alzheimer's or Parkinson's Disease
por: Hildebrandt, Helmut, et al.
Publicado: (2013)

Comment on “Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer's Type Dementia”
por: Uzun, Salih
Publicado: (2016)

Assessment of verbal and visuospatial working memory in mild cognitive impairment and Alzheimer's dementia
por: Kessels, Roy P.C., et al.
Publicado: (2015)

Theta-Gamma Coupling and Working Memory in Alzheimer’s Dementia and Mild Cognitive Impairment
por: Goodman, Michelle S., et al.
Publicado: (2018)

Neuropsychiatric Symptoms in Mild Cognitive Impairment and Dementia Due to AD: Relation With Disease Stage and Cognitive Deficits
por: Wiels, Wietse A., et al.
Publicado: (2021)

Hierarchical Interactions Model for Predicting Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD) Conversion
por: Li, Han, et al.
Publicado: (2014)

Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease: The AMARANTH and DAYBREAK-ALZ Randomized Clinical Trials
por: Wessels, Alette M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_p9kf8h5tod6nonelp2gf720anp