Targeting Lyn Kinase in Chorea-Acanthocytosis: A Translational Treatment Approach in a Rare Disease

Background: Chorea-acanthocytosis (ChAc) is a neurodegenerative disease caused by mutations in the VPS13A gene. It is characterized by several neurological symptoms and the appearance of acanthocytes. Elevated tyrosine kinase Lyn activity has been recently identified as one of the key pathophysiolog...

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Detalles Bibliográficos
Autores principales: Peikert, Kevin, Glaß, Hannes, Federti, Enrica, Matte, Alessandro, Pelzl, Lisann, Akgün, Katja, Ziemssen, Tjalf, Ordemann, Rainer, Lang, Florian, De Franceschi, Lucia, Hermann, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150322/
https://www.ncbi.nlm.nih.gov/pubmed/34068769
http://dx.doi.org/10.3390/jpm11050392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150322/
https://www.ncbi.nlm.nih.gov/pubmed/34068769
http://dx.doi.org/10.3390/jpm11050392

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