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Long-Term Mortality after Histoplasma Infection in People with HIV
Histoplasmosis is a common opportunistic infection in people with HIV (PWH); however, no study has looked at factors associated with the long-term mortality of histoplasmosis in PWH. We conducted a single-center retrospective study on the long-term mortality of PWH diagnosed with histoplasmosis betw...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150352/ https://www.ncbi.nlm.nih.gov/pubmed/34066845 http://dx.doi.org/10.3390/jof7050369 |
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author | Cherabie, Joseph Mazi, Patrick Rauseo, Adriana M. Ayres, Chapelle Larson, Lindsey Rutjanawech, Sasinuch O’Halloran, Jane Presti, Rachel Powderly, William G. Spec, Andrej |
author_facet | Cherabie, Joseph Mazi, Patrick Rauseo, Adriana M. Ayres, Chapelle Larson, Lindsey Rutjanawech, Sasinuch O’Halloran, Jane Presti, Rachel Powderly, William G. Spec, Andrej |
author_sort | Cherabie, Joseph |
collection | PubMed |
description | Histoplasmosis is a common opportunistic infection in people with HIV (PWH); however, no study has looked at factors associated with the long-term mortality of histoplasmosis in PWH. We conducted a single-center retrospective study on the long-term mortality of PWH diagnosed with histoplasmosis between 2002 and 2017. Patients were categorized into three groups based on length of survival after diagnosis: early mortality (death < 90 days), late mortality (death ≥ 90 days), and long-term survivors. Patients diagnosed during or after 2008 were considered part of the modern antiretroviral therapy (ART) era. Insurance type (private vs. public) was a surrogate indicator of socioeconomic status. Out of 54 PWH infected with histoplasmosis, overall mortality was 37%; 14.8% early mortality and 22.2% late mortality. There was no statistically significant difference in survival based on the availability of modern ART (p = 0.60). Insurance status reached statistical significance with 38% of survivors having private insurance versus only 8% having private insurance in the late mortality group (p = 0.05). High mortality persists despite the advent of modern ART, implicating a contribution from social determinants of health, such as private insurance. Larger studies are needed to elucidate the role of these factors in the mortality of PWH. |
format | Online Article Text |
id | pubmed-8150352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81503522021-05-27 Long-Term Mortality after Histoplasma Infection in People with HIV Cherabie, Joseph Mazi, Patrick Rauseo, Adriana M. Ayres, Chapelle Larson, Lindsey Rutjanawech, Sasinuch O’Halloran, Jane Presti, Rachel Powderly, William G. Spec, Andrej J Fungi (Basel) Article Histoplasmosis is a common opportunistic infection in people with HIV (PWH); however, no study has looked at factors associated with the long-term mortality of histoplasmosis in PWH. We conducted a single-center retrospective study on the long-term mortality of PWH diagnosed with histoplasmosis between 2002 and 2017. Patients were categorized into three groups based on length of survival after diagnosis: early mortality (death < 90 days), late mortality (death ≥ 90 days), and long-term survivors. Patients diagnosed during or after 2008 were considered part of the modern antiretroviral therapy (ART) era. Insurance type (private vs. public) was a surrogate indicator of socioeconomic status. Out of 54 PWH infected with histoplasmosis, overall mortality was 37%; 14.8% early mortality and 22.2% late mortality. There was no statistically significant difference in survival based on the availability of modern ART (p = 0.60). Insurance status reached statistical significance with 38% of survivors having private insurance versus only 8% having private insurance in the late mortality group (p = 0.05). High mortality persists despite the advent of modern ART, implicating a contribution from social determinants of health, such as private insurance. Larger studies are needed to elucidate the role of these factors in the mortality of PWH. MDPI 2021-05-08 /pmc/articles/PMC8150352/ /pubmed/34066845 http://dx.doi.org/10.3390/jof7050369 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cherabie, Joseph Mazi, Patrick Rauseo, Adriana M. Ayres, Chapelle Larson, Lindsey Rutjanawech, Sasinuch O’Halloran, Jane Presti, Rachel Powderly, William G. Spec, Andrej Long-Term Mortality after Histoplasma Infection in People with HIV |
title | Long-Term Mortality after Histoplasma Infection in People with HIV |
title_full | Long-Term Mortality after Histoplasma Infection in People with HIV |
title_fullStr | Long-Term Mortality after Histoplasma Infection in People with HIV |
title_full_unstemmed | Long-Term Mortality after Histoplasma Infection in People with HIV |
title_short | Long-Term Mortality after Histoplasma Infection in People with HIV |
title_sort | long-term mortality after histoplasma infection in people with hiv |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150352/ https://www.ncbi.nlm.nih.gov/pubmed/34066845 http://dx.doi.org/10.3390/jof7050369 |
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