Cargando…

Hexarelin Modulation of MAPK and PI3K/Akt Pathways in Neuro-2A Cells Inhibits Hydrogen Peroxide—Induced Apoptotic Toxicity

Hexarelin, a synthetic hexapeptide, exerts cyto-protective effects at the mitochondrial level in cardiac and skeletal muscles, both in vitro and in vivo, may also have important neuroprotective bioactivities. This study examined the inhibitory effects of hexarelin on hydrogen peroxide (H(2)O(2))-ind...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meanti, Ramona, Rizzi, Laura, Bresciani, Elena, Molteni, Laura, Locatelli, Vittorio, Coco, Silvia, Omeljaniuk, Robert John, Torsello, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150489/ https://www.ncbi.nlm.nih.gov/pubmed/34066741 http://dx.doi.org/10.3390/ph14050444

Ejemplares similares

Protective Effects of Hexarelin and JMV2894 in a Human Neuroblastoma Cell Line Expressing the SOD1-G93A Mutated Protein
por: Meanti, Ramona, et al.
Publicado: (2023)

Hexarelin modulates lung mechanics, inflammation, and fibrosis in acute lung injury
por: Zambelli, Vanessa, et al.
Publicado: (2021)

Growth Hormone Secretagogues and the Regulation of Calcium Signaling in Muscle
por: Bresciani, Elena, et al.
Publicado: (2019)

TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling
por: Bresciani, Elena, et al.
Publicado: (2019)

STIM Proteins and Orai Ca(2+) Channels Are Involved in the Intracellular Pathways Activated by TLQP-21 in RAW264.7 Macrophages
por: Molteni, Laura, et al.
Publicado: (2018)

miRNA-218 Targets Lipin-1 and Glucose Transporter Type 4 Genes in 3T3-L1 Cells Treated With Lopinavir/Ritonavir
por: Bresciani, Elena, et al.
Publicado: (2019)

Characterization of microRNA Levels in Synovial Fluid from Knee Osteoarthritis and Anterior Cruciate Ligament Tears
por: Rizzi, Laura, et al.
Publicado: (2022)

miRNA Expression Profiling in Subcutaneous Adipose Tissue of Monozygotic Twins Discordant for HIV Infection: Validation of Differentially Expressed miRNA and Bioinformatic Analysis
por: Bresciani, Elena, et al.
Publicado: (2022)

Palmitoylethanolamide Modulation of Microglia Activation: Characterization of Mechanisms of Action and Implication for Its Neuroprotective Effects
por: D’Aloia, Alessia, et al.
Publicado: (2021)

Androgen Therapy in Neurodegenerative Diseases
por: Bianchi, Vittorio Emanuele, et al.
Publicado: (2020)

JMV5656, A Novel Derivative of TLQP-21, Triggers the Activation of a Calcium-Dependent Potassium Outward Current in Microglial Cells
por: Rivolta, Ilaria, et al.
Publicado: (2017)

The cardiovascular action of hexarelin
por: Mao, Yuanjie, et al.
Publicado: (2014)

Pharmacological and Biochemical Characterization of TLQP-21 Activation of a Binding Site on CHO Cells
por: Molteni, Laura, et al.
Publicado: (2017)

Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia
por: Sirago, Giuseppe, et al.
Publicado: (2017)

Hexarelin Signaling to PPAR [Formula: see text] in Metabolic Diseases
por: Demers, Annie, et al.
Publicado: (2008)

Improvement of cardiomyocyte function by in vivo hexarelin treatment in streptozotocin‐induced diabetic rats
por: Zhang, Xinli, et al.
Publicado: (2018)

Modulation of PTEN by hexarelin attenuates coronary artery ligation-induced heart failure in rats
por: AGBO, Elvis, et al.
Publicado: (2019)

The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin
por: Dahlgren, David, et al.
Publicado: (2020)

Using Synchrotron Radiation Imaging Techniques to Elucidate the Actions of Hexarelin in the Heart of Small Animal Models
por: Waddingham, Mark T., et al.
Publicado: (2022)

Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats
por: Dahlgren, David, et al.
Publicado: (2021)

MAPK Pathway Inhibitors Attenuated Hydrogen Peroxide Induced Damage in Neural Cells
por: Fan, Zhenwei, et al.
Publicado: (2019)

Non-apoptotic function of caspases in a cellular model of hydrogen peroxide-associated colitis
por: Poehlmann, Angela, et al.
Publicado: (2013)

Hydroxytyrosol inhibits hydrogen peroxide-induced apoptotic signaling via labile iron chelation
por: Kitsati, Natalia, et al.
Publicado: (2016)

Hexarelin alleviates apoptosis on ischemic acute kidney injury via MDM2/p53 pathway
por: Guan, Chen, et al.
Publicado: (2023)

Protective but Not Anticonvulsant Effects of Ghrelin and JMV-1843 in the Pilocarpine Model of Status epilepticus
por: Lucchi, Chiara, et al.
Publicado: (2013)

Effects of Carbazole Derivatives on Neurite Outgrowth and Hydrogen Peroxide-Induced Cytotoxicity in Neuro2a Cells
por: Furukawa, Yoshiko, et al.
Publicado: (2019)

Peroxide of Hydrogen
Publicado: (1888)

Peroxide of Hydrogen
Publicado: (1885)

Peroxide of Hydrogen
Publicado: (1887)

Peroxide of Hydrogen
Publicado: (1891)

Peroxide of Hydrogen
Publicado: (1896)

Peroxide of Hydrogen
Publicado: (1896)

Akt attenuates apoptotic death through phosphorylation of H2A under hydrogen peroxide-induced oxidative stress in PC12 cells and hippocampal neurons
por: Park, Ji Hye, et al.
Publicado: (2016)

Hexarelin treatment preserves myocardial function and reduces cardiac fibrosis in a mouse model of acute myocardial infarction
por: McDonald, Hayley, et al.
Publicado: (2018)

Intranasal delivery of mesenchymal stem cell‐derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease
por: Losurdo, Morris, et al.
Publicado: (2020)

Review of aerosolized hydrogen peroxide, vaporized hydrogen peroxide, and hydrogen peroxide gas plasma in the decontamination of filtering facepiece respirators
por: Berger, Daniel, et al.
Publicado: (2022)

Antioxidant Effects of Turbo cornutus By-Products Visceral Extract against Hydrogen Peroxide-Induced Oxidative Stress by Regulating MAPK and Akt Signaling Pathways in Vero Cells
por: Lee, Yeon-Ji, et al.
Publicado: (2023)

Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies
por: Conte, Elena, et al.
Publicado: (2020)

Enhanced Pulsatile Growth Hormone Secretion and Altered Metabolic Hormones by in Vivo Hexarelin Treatment in Streptozotocin-Induced Diabetic Rats
por: Zhang, Xinli, et al.
Publicado: (2018)

Hydrogen Peroxide in Adaptation
por: Spasojević, Ivan, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_g2pfpot2lu4r9kufjhu03a7866