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Prediction and follow-up of risk factors for severe SARS-CoV-2 pneumonia and application of CT visual scoring

BACKGROUND: The SARS-CoV-2 pneumonia infection is associated with high rates of hospitalization and mortality and this has placed healthcare systems under strain. Our study provides a novel method for the progress prediction, clinical treatment and prognosis of NCP, and has important clinical value...

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Autores principales: Ye, Yingjian, Wu, Xiaxia, Li, Xiumei, Xu, Chunmei, Wang, Qingpeng, Yuan, Wenhuan, Zhang, Li, Li, Huan, Zheng, Lishi, Li, Qiongxia, He, Zhibing, Liu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150490/
https://www.ncbi.nlm.nih.gov/pubmed/33682755
http://dx.doi.org/10.3233/THC-218016
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author Ye, Yingjian
Wu, Xiaxia
Li, Xiumei
Xu, Chunmei
Wang, Qingpeng
Yuan, Wenhuan
Zhang, Li
Li, Huan
Zheng, Lishi
Li, Qiongxia
He, Zhibing
Liu, Bo
author_facet Ye, Yingjian
Wu, Xiaxia
Li, Xiumei
Xu, Chunmei
Wang, Qingpeng
Yuan, Wenhuan
Zhang, Li
Li, Huan
Zheng, Lishi
Li, Qiongxia
He, Zhibing
Liu, Bo
author_sort Ye, Yingjian
collection PubMed
description BACKGROUND: The SARS-CoV-2 pneumonia infection is associated with high rates of hospitalization and mortality and this has placed healthcare systems under strain. Our study provides a novel method for the progress prediction, clinical treatment and prognosis of NCP, and has important clinical value for timely treatment of severe NCP patients. OBJECTIVE: To summarize the clinical features and severe illness risk factors of the patients with novel coronavirus pneumonia (NCP), in order to provide support for the progression prediction, clinical treatment and prognosis of NCP patients. MATERIALS AND METHODS: A total of 196 NCP patients treated in our hospital from January 25, 2020 to June 21, 2020 were divided into the severe group and the mild group. The clinical features of the two groups were analyzed and compared. The risk factors were explored by using multivariate logistic regression, and the receiver operating characteristic (ROC) curve was obtained. The correlations of the risk factors with the prognosis of NCP were investigated combined with the lung function test. RESULTS: The primary clinical symptoms of 196 cases of NCP included fever in 167 cases (85.2%) and cough in 121 cases (61.73%). The chest computed tomography (CT) scans of the 178 cases (90.81%) showed a typical ground-glass opacification. In 149 cases, the lymphocyte count was decreased, while the levels of creatine kinase (CK), lactate dehydrogenase (LDH), c-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and D-dimer (D-D) increased. 44 cases (22.45%) were found to be severely ill. The multivariate logistic regression analysis demonstrated that age, underlying disease, length of hospital stay, body mass index (BMI), LDH, chest CT visual score, absolute lymphocyte count (ALC) and CRP were risk factors for severe
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spelling pubmed-81504902021-06-09 Prediction and follow-up of risk factors for severe SARS-CoV-2 pneumonia and application of CT visual scoring Ye, Yingjian Wu, Xiaxia Li, Xiumei Xu, Chunmei Wang, Qingpeng Yuan, Wenhuan Zhang, Li Li, Huan Zheng, Lishi Li, Qiongxia He, Zhibing Liu, Bo Technol Health Care Research Article BACKGROUND: The SARS-CoV-2 pneumonia infection is associated with high rates of hospitalization and mortality and this has placed healthcare systems under strain. Our study provides a novel method for the progress prediction, clinical treatment and prognosis of NCP, and has important clinical value for timely treatment of severe NCP patients. OBJECTIVE: To summarize the clinical features and severe illness risk factors of the patients with novel coronavirus pneumonia (NCP), in order to provide support for the progression prediction, clinical treatment and prognosis of NCP patients. MATERIALS AND METHODS: A total of 196 NCP patients treated in our hospital from January 25, 2020 to June 21, 2020 were divided into the severe group and the mild group. The clinical features of the two groups were analyzed and compared. The risk factors were explored by using multivariate logistic regression, and the receiver operating characteristic (ROC) curve was obtained. The correlations of the risk factors with the prognosis of NCP were investigated combined with the lung function test. RESULTS: The primary clinical symptoms of 196 cases of NCP included fever in 167 cases (85.2%) and cough in 121 cases (61.73%). The chest computed tomography (CT) scans of the 178 cases (90.81%) showed a typical ground-glass opacification. In 149 cases, the lymphocyte count was decreased, while the levels of creatine kinase (CK), lactate dehydrogenase (LDH), c-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and D-dimer (D-D) increased. 44 cases (22.45%) were found to be severely ill. The multivariate logistic regression analysis demonstrated that age, underlying disease, length of hospital stay, body mass index (BMI), LDH, chest CT visual score, absolute lymphocyte count (ALC) and CRP were risk factors for severe IOS Press 2021-03-25 /pmc/articles/PMC8150490/ /pubmed/33682755 http://dx.doi.org/10.3233/THC-218016 Text en © 2021 – The authors. Published by IOS Press. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ye, Yingjian
Wu, Xiaxia
Li, Xiumei
Xu, Chunmei
Wang, Qingpeng
Yuan, Wenhuan
Zhang, Li
Li, Huan
Zheng, Lishi
Li, Qiongxia
He, Zhibing
Liu, Bo
Prediction and follow-up of risk factors for severe SARS-CoV-2 pneumonia and application of CT visual scoring
title Prediction and follow-up of risk factors for severe SARS-CoV-2 pneumonia and application of CT visual scoring
title_full Prediction and follow-up of risk factors for severe SARS-CoV-2 pneumonia and application of CT visual scoring
title_fullStr Prediction and follow-up of risk factors for severe SARS-CoV-2 pneumonia and application of CT visual scoring
title_full_unstemmed Prediction and follow-up of risk factors for severe SARS-CoV-2 pneumonia and application of CT visual scoring
title_short Prediction and follow-up of risk factors for severe SARS-CoV-2 pneumonia and application of CT visual scoring
title_sort prediction and follow-up of risk factors for severe sars-cov-2 pneumonia and application of ct visual scoring
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150490/
https://www.ncbi.nlm.nih.gov/pubmed/33682755
http://dx.doi.org/10.3233/THC-218016
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