3D segmentation of lungs with juxta-pleural tumor using the improved active shape model approach

BACKGROUND AND OBJECTIVE: At present, there are many methods for pathological lung segmentation. However, there are still two unresolved problems. (1) The search steps in traditional ASM is a least square optimization method, which is sensitive to outlier marker points, and it makes the profile update to the transition area in the middle of normal lung tissue and tumor rather than a true lung contour. (2) If the noise images exist in the training dataset, the corrected shape model cannot be constructed. METHODS: To solve the first problem, we proposed a new ASM algorithm. Firstly, we detected these outlier marker points by a distance method, and then the different searching functions to the abnormal and normal marker points are applied. To solve the second problem, robust principal component analysis (RPCA) of low rank theory can remove noise, so the proposed method combines RPCA instead of PCA with ASM to solve this problem. Low rank decompose for marker points matrix of training dataset and covariance matrix of PCA will be done before segmentation using ASM. RESULTS: Using the proposed method to segment 122 lung images with juxta-pleural tumors of EMPIRE10 database, got the overlap rate with the gold standard as 94.5%. While the accuracy of ASM based on PCA is only 69.5%. CONCLUSIONS: The results showed that when the noise sample is contained in the training sample set, a good segmentation result for the lungs with juxta-pleural tumors can be obtained by the ASM based on RPCA.