Cargando…

Real-World Survival Outcomes Associated With First-Line Immunotherapy, Targeted Therapy, and Combination Therapy for Metastatic Clear Cell Renal Cell Carcinoma

IMPORTANCE: Clinical trials have shown an overall survival (OS) benefit associated with first-line immunotherapy (IT) and combination targeted therapy (TT) and IT regimens compared with TT among patients with metastatic clear cell renal cell carcinoma (RCC). Generalizability of these findings in a r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chakiryan, Nicholas H., Jiang, Da David, Gillis, Kyle A., Green, Elizabeth, Hajiran, Ali, Hugar, Lee, Zemp, Logan, Zhang, Jingsong, Jain, Rohit K., Chahoud, Jad, Spiess, Philippe E., Sexton, Wade, Gilbert, Scott M., Manley, Brandon J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Medical Association 2021
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150693/ https://www.ncbi.nlm.nih.gov/pubmed/34032854 http://dx.doi.org/10.1001/jamanetworkopen.2021.11329

Ejemplares similares

Survival Outcomes Associated With Cytoreductive Nephrectomy in Patients With Metastatic Clear Cell Renal Cell Carcinoma
por: Chakiryan, Nicholas H., et al.
Publicado: (2022)

Spatial clustering of CD68+ tumor associated macrophages with tumor cells is associated with worse overall survival in metastatic clear cell renal cell carcinoma
por: Chakiryan, Nicholas H., et al.
Publicado: (2021)

Geospatial Cellular Distribution of Cancer-Associated Fibroblasts Significantly Impacts Clinical Outcomes in Metastatic Clear Cell Renal Cell Carcinoma
por: Chakiryan, Nicholas H., et al.
Publicado: (2021)

Revisiting mechanisms of resistance to immunotherapies in metastatic clear-cell renal-cell carcinoma
por: Chatwal, Monica Sheila, et al.
Publicado: (2023)

The Immune Microenvironment in Penile Cancer and Rationale for Immunotherapy
por: Ahmed, Mohamed E., et al.
Publicado: (2020)

Dissecting Outcomes: Should Cytoreductive Nephrectomy Be Performed for Patients With Metastatic Renal Cell Carcinoma With Sarcomatoid Dedifferentiation?
por: Adashek, Jacob J., et al.
Publicado: (2021)

Influence of gene expression on survival of clear cell renal cell carcinoma
por: Berglund, Anders, et al.
Publicado: (2020)

Geospatial characterization of immune cell distributions and dynamics across the microenvironment in clear cell renal cell carcinoma
por: Chakiryan, Nicholas H, et al.
Publicado: (2023)

Prognostic predictors of lymph node metastasis in penile cancer: a systematic review
por: Zekan, David S., et al.
Publicado: (2021)

Adding Cyclooxygenase Inhibitors to Immune Checkpoint Inhibitors Did Not Improve Outcomes in Metastatic Renal Cell Carcinoma
por: Zhang, Yumeng, et al.
Publicado: (2022)

An update on treatment of penile cancer
por: Chadha, Juskaran, et al.
Publicado: (2022)

Penile cancer: Updates in systemic therapy
por: Joshi, Vidhu B., et al.
Publicado: (2022)

Case Report: Two Cases of Chemotherapy Refractory Metastatic Penile Squamous Cell Carcinoma With Extreme Durable Response to Pembrolizumab
por: Chahoud, Jad, et al.
Publicado: (2020)

Cytoreductive Nephrectomy Following Immune Checkpoint Inhibitor Therapy Is Safe and Facilitates Treatment-free Intervals
por: Shapiro, Daniel D., et al.
Publicado: (2023)

Survival Benefits of Adjuvant Chemotherapy for Positive Soft Tissue Surgical Margins Following Radical Cystectomy in Bladder Cancer with Extravesical Extension
por: Murthy, Prithvi B., et al.
Publicado: (2023)

Quantification of T- and B-cell Immune Receptor Distribution Diversity Characterizes Immune Cell Infiltration and Lymphocyte Heterogeneity in Clear Cell Renal Cell Carcinoma
por: Ferrall-Fairbanks, Meghan C., et al.
Publicado: (2022)

An Analysis of Nectin-4 (PVRL4) in Penile Squamous Cell Carcinoma
por: Grass, G.Daniel, et al.
Publicado: (2023)

Undiagnosed prostatic malignancy at the time of radical cystoprostatectomy after prior prostatic radiation therapy
por: Sharma, Pranav, et al.
Publicado: (2016)

Genomic Alterations and Outcomes with VEGF-Targeted Therapy in Patients with Clear Cell Renal Cell Carcinoma
por: Carlo, M.I., et al.
Publicado: (2017)

The target therapy of ovarian clear cell carcinoma
por: Jin, Ying, et al.
Publicado: (2014)

Emerging Therapies for Advanced Clear Cell Renal Cell Carcinoma
por: Toth, Alexander T., et al.
Publicado: (2020)

Identification of immune subtypes to guide immunotherapy and targeted therapy in clear cell renal cell carcinoma
por: Xu, Chen, et al.
Publicado: (2022)

Potential Application of Pyroptosis in Kidney Renal Clear Cell Carcinoma Immunotherapy and Targeted Therapy
por: Qi, Xiaochen, et al.
Publicado: (2022)

Surgical Site Infections Following Spine Surgery: Eliminating the Controversies in the Diagnosis
por: Chahoud, Jad, et al.
Publicado: (2014)

The Continuing Question of Adjuvant Therapy in Clear Cell Renal Cell Carcinoma
por: Berg, Stephanie A., et al.
Publicado: (2022)

Ubiquitin Modification Patterns of Clear Cell Renal Cell Carcinoma and the Ubiquitin Score to Aid Immunotherapy and Targeted Therapy
por: Zhou, Peng, et al.
Publicado: (2021)

An Assessment of the Penile Squamous Cell Carcinoma Surfaceome for Biomarker and Therapeutic Target Discovery
por: Grass, George Daniel, et al.
Publicado: (2023)

Implications of Programmed Death Ligand-1 Positivity in Non-Clear Cell Renal Cell Carcinoma
por: Chipollini, Juan, et al.
Publicado: (2018)

New perspectives on molecular targeted therapy in ovarian clear cell carcinoma
por: Tan, D S P, et al.
Publicado: (2013)

The Goal of Achieving High-Quality Surgical First-Line Therapy in Patients with Penile Cancer Is Important; However, Some Collective Efforts Are Still Required in Order to Reach It. Comment on Brassetti et al. Combined Reporting of Surgical Quality and Cancer Control after Surgical Treatment for Penile Tumors with Inguinal Lymph Node Dissection: The Tetrafecta Achievement. Curr. Oncol. 2023, 30, 1882–1892
por: May, Matthias, et al.
Publicado: (2023)

Clinical impact of targeted therapies in patients with metastatic clear-cell renal cell carcinoma
por: Nerich, Virginie, et al.
Publicado: (2014)

Prognostic Factors for Localized Clear Cell Renal Cell Carcinoma and Their Application in Adjuvant Therapy
por: Mattila, Kalle E., et al.
Publicado: (2022)

The genomic landscape of metastatic clear cell renal cell carcinoma after systemic therapy
por: van der Mijn, Johannes C., et al.
Publicado: (2022)

Research Progress of Tumor Microenvironment Targeted Therapy for Clear Cell Renal Cell Carcinoma
por: Huang, Yongqiang, et al.
Publicado: (2023)

Primary and acquired resistance to first-line therapy for clear cell renal cell carcinoma
por: Astore, Serena, et al.
Publicado: (2023)

Systemic and intravesical adoptive cell therapy of tumor-reactive T cells can decrease bladder tumor growth in vivo
por: Bunch, Brittany L, et al.
Publicado: (2020)

The Prognostic Role of Human Papillomavirus and p16 Status in Penile Squamous Cell Carcinoma—A Systematic Review
por: Parza, Kevin, et al.
Publicado: (2023)

5-hydroxymethylcytosine sequencing in plasma cell-free DNA identifies unique epigenomic features in prostate cancer patients resistant to androgen deprivation therapy
por: Li, Qianxia, et al.
Publicado: (2023)

Systemic therapy for advanced clear cell renal cell carcinoma after discontinuation of immune-oncology and VEGF targeted therapy combinations
por: Ged, Yasser, et al.
Publicado: (2020)

Ovarian cancer: new developments in clear cell carcinoma and hopes for targeted therapy
por: Yamashita, Yoriko
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1iddd66asjs1b7psfif40n9edi