Preparation of the Key Dolutegravir Intermediate via MgBr(2)-Promoted Cyclization

A novel approach for synthesizing the key dolutegravir intermediate is described via MgBr(2)-promoted intramolecular cyclization. Condensation of commercially available methyl oxalyl chloride and ethyl 3-(N,N-dimethylamino)acrylate afforded the vinylogous amide in an excellent yield. Subsequent subs...

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Detalles Bibliográficos
Autores principales: Kong, Jiahui, Xia, Haijian, He, Renbao, Chen, Hao, Yu, Yongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150840/
https://www.ncbi.nlm.nih.gov/pubmed/34064812
http://dx.doi.org/10.3390/molecules26102850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150840/
https://www.ncbi.nlm.nih.gov/pubmed/34064812
http://dx.doi.org/10.3390/molecules26102850

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