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White Matter Lesions as Possible Predictors of Audiological Performance in Adults after Cochlear Implantation

The presented prospective study investigated whether structural brain damage, measured with the Fazekas score, could predict hearing rehabilitation outcomes with cochlear implantation (CI). With a follow-up period of 24 months, this study included 49 bilaterally, postlingually hearing impaired CI ca...

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Autores principales: Knopke, Steffen, Bauknecht, Hans-Christian, Gräbel, Stefan, Häußler, Sophia Marie, Szczepek, Agnieszka J., Olze, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150980/
https://www.ncbi.nlm.nih.gov/pubmed/34066703
http://dx.doi.org/10.3390/brainsci11050600
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author Knopke, Steffen
Bauknecht, Hans-Christian
Gräbel, Stefan
Häußler, Sophia Marie
Szczepek, Agnieszka J.
Olze, Heidi
author_facet Knopke, Steffen
Bauknecht, Hans-Christian
Gräbel, Stefan
Häußler, Sophia Marie
Szczepek, Agnieszka J.
Olze, Heidi
author_sort Knopke, Steffen
collection PubMed
description The presented prospective study investigated whether structural brain damage, measured with the Fazekas score, could predict hearing rehabilitation outcomes with cochlear implantation (CI). With a follow-up period of 24 months, this study included 49 bilaterally, postlingually hearing impaired CI candidates for unilateral CI (67.3 ± 8.7 years; 20 men, 29 women) older than 50 at the time of implantation. The differences in the predictive value between two age groups, 50–70 year-olds (mid-age; n = 26) and over 70-year-olds (elderly; n = 23), were analyzed. The patients were evaluated using speech perception (SP) measured in quiet (Freiburg monosyllabic test; FMT) and noise (Oldenburg sentence test; OLSA). The subjective hearing ability was assessed using Oldenburg inventory (OI). The Fazekas PVWM score predicted postoperative speech perception two years after CI in the mid-age population. The periventricular white matter lesions (PVWM) could explain 27.4% of the speech perception (FMT) variance. Our findings support the hypothesis about the influence of pre-existing WMLs on CI outcome. We recommend the evaluation of Fazekas score as a predictive factor for post-implantation hearing ability.
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spelling pubmed-81509802021-05-27 White Matter Lesions as Possible Predictors of Audiological Performance in Adults after Cochlear Implantation Knopke, Steffen Bauknecht, Hans-Christian Gräbel, Stefan Häußler, Sophia Marie Szczepek, Agnieszka J. Olze, Heidi Brain Sci Article The presented prospective study investigated whether structural brain damage, measured with the Fazekas score, could predict hearing rehabilitation outcomes with cochlear implantation (CI). With a follow-up period of 24 months, this study included 49 bilaterally, postlingually hearing impaired CI candidates for unilateral CI (67.3 ± 8.7 years; 20 men, 29 women) older than 50 at the time of implantation. The differences in the predictive value between two age groups, 50–70 year-olds (mid-age; n = 26) and over 70-year-olds (elderly; n = 23), were analyzed. The patients were evaluated using speech perception (SP) measured in quiet (Freiburg monosyllabic test; FMT) and noise (Oldenburg sentence test; OLSA). The subjective hearing ability was assessed using Oldenburg inventory (OI). The Fazekas PVWM score predicted postoperative speech perception two years after CI in the mid-age population. The periventricular white matter lesions (PVWM) could explain 27.4% of the speech perception (FMT) variance. Our findings support the hypothesis about the influence of pre-existing WMLs on CI outcome. We recommend the evaluation of Fazekas score as a predictive factor for post-implantation hearing ability. MDPI 2021-05-08 /pmc/articles/PMC8150980/ /pubmed/34066703 http://dx.doi.org/10.3390/brainsci11050600 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Knopke, Steffen
Bauknecht, Hans-Christian
Gräbel, Stefan
Häußler, Sophia Marie
Szczepek, Agnieszka J.
Olze, Heidi
White Matter Lesions as Possible Predictors of Audiological Performance in Adults after Cochlear Implantation
title White Matter Lesions as Possible Predictors of Audiological Performance in Adults after Cochlear Implantation
title_full White Matter Lesions as Possible Predictors of Audiological Performance in Adults after Cochlear Implantation
title_fullStr White Matter Lesions as Possible Predictors of Audiological Performance in Adults after Cochlear Implantation
title_full_unstemmed White Matter Lesions as Possible Predictors of Audiological Performance in Adults after Cochlear Implantation
title_short White Matter Lesions as Possible Predictors of Audiological Performance in Adults after Cochlear Implantation
title_sort white matter lesions as possible predictors of audiological performance in adults after cochlear implantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150980/
https://www.ncbi.nlm.nih.gov/pubmed/34066703
http://dx.doi.org/10.3390/brainsci11050600
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