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Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain
Brain tissue may be especially sensitive to electromagnetic phenomena provoking signs of neural stress in cerebral activity. Fifty-four adult female Sprague-Dawley rats underwent ELISA and immunohistochemistry testing of four relevant anatomical areas of the cerebrum to measure biomarkers indicating...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151023/ https://www.ncbi.nlm.nih.gov/pubmed/34065959 http://dx.doi.org/10.3390/ijms22105103 |
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author | Othman, Haifa López-Furelos, Alberto Leiro-Vidal, José Manuel Ammari, Mohamed Sakly, Mohsen Abdelmelek, Hafedh Salas-Sánchez, Aarón Ángel Ares-Pena, Francisco López-Martín, Elena |
author_facet | Othman, Haifa López-Furelos, Alberto Leiro-Vidal, José Manuel Ammari, Mohamed Sakly, Mohsen Abdelmelek, Hafedh Salas-Sánchez, Aarón Ángel Ares-Pena, Francisco López-Martín, Elena |
author_sort | Othman, Haifa |
collection | PubMed |
description | Brain tissue may be especially sensitive to electromagnetic phenomena provoking signs of neural stress in cerebral activity. Fifty-four adult female Sprague-Dawley rats underwent ELISA and immunohistochemistry testing of four relevant anatomical areas of the cerebrum to measure biomarkers indicating induction of heat shock protein 70 (HSP-70), glucocorticoid receptors (GCR) or glial fibrillary acidic protein (GFAP) after single or repeated exposure to 2.45 GHz radiation in the experimental set-up. Neither radiation regime caused tissue heating, so thermal effects can be ruled out. A progressive decrease in GCR and HSP-70 was observed after acute or repeated irradiation in the somatosensory cortex, hypothalamus and hippocampus. In the limbic cortex; however, values for both biomarkers were significantly higher after repeated exposure to irradiation when compared to control animals. GFAP values in brain tissue after irradiation were not significantly different or were even lower than those of nonirradiated animals in all brain regions studied. Our results suggest that repeated exposure to 2.45 GHz elicited GCR/HSP-70 dysregulation in the brain, triggering a state of stress that could decrease tissue anti-inflammatory action without favoring glial proliferation and make the nervous system more vulnerable. |
format | Online Article Text |
id | pubmed-8151023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81510232021-05-27 Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain Othman, Haifa López-Furelos, Alberto Leiro-Vidal, José Manuel Ammari, Mohamed Sakly, Mohsen Abdelmelek, Hafedh Salas-Sánchez, Aarón Ángel Ares-Pena, Francisco López-Martín, Elena Int J Mol Sci Article Brain tissue may be especially sensitive to electromagnetic phenomena provoking signs of neural stress in cerebral activity. Fifty-four adult female Sprague-Dawley rats underwent ELISA and immunohistochemistry testing of four relevant anatomical areas of the cerebrum to measure biomarkers indicating induction of heat shock protein 70 (HSP-70), glucocorticoid receptors (GCR) or glial fibrillary acidic protein (GFAP) after single or repeated exposure to 2.45 GHz radiation in the experimental set-up. Neither radiation regime caused tissue heating, so thermal effects can be ruled out. A progressive decrease in GCR and HSP-70 was observed after acute or repeated irradiation in the somatosensory cortex, hypothalamus and hippocampus. In the limbic cortex; however, values for both biomarkers were significantly higher after repeated exposure to irradiation when compared to control animals. GFAP values in brain tissue after irradiation were not significantly different or were even lower than those of nonirradiated animals in all brain regions studied. Our results suggest that repeated exposure to 2.45 GHz elicited GCR/HSP-70 dysregulation in the brain, triggering a state of stress that could decrease tissue anti-inflammatory action without favoring glial proliferation and make the nervous system more vulnerable. MDPI 2021-05-12 /pmc/articles/PMC8151023/ /pubmed/34065959 http://dx.doi.org/10.3390/ijms22105103 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Othman, Haifa López-Furelos, Alberto Leiro-Vidal, José Manuel Ammari, Mohamed Sakly, Mohsen Abdelmelek, Hafedh Salas-Sánchez, Aarón Ángel Ares-Pena, Francisco López-Martín, Elena Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain |
title | Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain |
title_full | Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain |
title_fullStr | Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain |
title_full_unstemmed | Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain |
title_short | Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain |
title_sort | exposure to 2.45 ghz radiation triggers changes in hsp-70, glucocorticoid receptors and gfap biomarkers in rat brain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151023/ https://www.ncbi.nlm.nih.gov/pubmed/34065959 http://dx.doi.org/10.3390/ijms22105103 |
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