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Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain

Brain tissue may be especially sensitive to electromagnetic phenomena provoking signs of neural stress in cerebral activity. Fifty-four adult female Sprague-Dawley rats underwent ELISA and immunohistochemistry testing of four relevant anatomical areas of the cerebrum to measure biomarkers indicating...

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Autores principales: Othman, Haifa, López-Furelos, Alberto, Leiro-Vidal, José Manuel, Ammari, Mohamed, Sakly, Mohsen, Abdelmelek, Hafedh, Salas-Sánchez, Aarón Ángel, Ares-Pena, Francisco, López-Martín, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151023/
https://www.ncbi.nlm.nih.gov/pubmed/34065959
http://dx.doi.org/10.3390/ijms22105103
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author Othman, Haifa
López-Furelos, Alberto
Leiro-Vidal, José Manuel
Ammari, Mohamed
Sakly, Mohsen
Abdelmelek, Hafedh
Salas-Sánchez, Aarón Ángel
Ares-Pena, Francisco
López-Martín, Elena
author_facet Othman, Haifa
López-Furelos, Alberto
Leiro-Vidal, José Manuel
Ammari, Mohamed
Sakly, Mohsen
Abdelmelek, Hafedh
Salas-Sánchez, Aarón Ángel
Ares-Pena, Francisco
López-Martín, Elena
author_sort Othman, Haifa
collection PubMed
description Brain tissue may be especially sensitive to electromagnetic phenomena provoking signs of neural stress in cerebral activity. Fifty-four adult female Sprague-Dawley rats underwent ELISA and immunohistochemistry testing of four relevant anatomical areas of the cerebrum to measure biomarkers indicating induction of heat shock protein 70 (HSP-70), glucocorticoid receptors (GCR) or glial fibrillary acidic protein (GFAP) after single or repeated exposure to 2.45 GHz radiation in the experimental set-up. Neither radiation regime caused tissue heating, so thermal effects can be ruled out. A progressive decrease in GCR and HSP-70 was observed after acute or repeated irradiation in the somatosensory cortex, hypothalamus and hippocampus. In the limbic cortex; however, values for both biomarkers were significantly higher after repeated exposure to irradiation when compared to control animals. GFAP values in brain tissue after irradiation were not significantly different or were even lower than those of nonirradiated animals in all brain regions studied. Our results suggest that repeated exposure to 2.45 GHz elicited GCR/HSP-70 dysregulation in the brain, triggering a state of stress that could decrease tissue anti-inflammatory action without favoring glial proliferation and make the nervous system more vulnerable.
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spelling pubmed-81510232021-05-27 Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain Othman, Haifa López-Furelos, Alberto Leiro-Vidal, José Manuel Ammari, Mohamed Sakly, Mohsen Abdelmelek, Hafedh Salas-Sánchez, Aarón Ángel Ares-Pena, Francisco López-Martín, Elena Int J Mol Sci Article Brain tissue may be especially sensitive to electromagnetic phenomena provoking signs of neural stress in cerebral activity. Fifty-four adult female Sprague-Dawley rats underwent ELISA and immunohistochemistry testing of four relevant anatomical areas of the cerebrum to measure biomarkers indicating induction of heat shock protein 70 (HSP-70), glucocorticoid receptors (GCR) or glial fibrillary acidic protein (GFAP) after single or repeated exposure to 2.45 GHz radiation in the experimental set-up. Neither radiation regime caused tissue heating, so thermal effects can be ruled out. A progressive decrease in GCR and HSP-70 was observed after acute or repeated irradiation in the somatosensory cortex, hypothalamus and hippocampus. In the limbic cortex; however, values for both biomarkers were significantly higher after repeated exposure to irradiation when compared to control animals. GFAP values in brain tissue after irradiation were not significantly different or were even lower than those of nonirradiated animals in all brain regions studied. Our results suggest that repeated exposure to 2.45 GHz elicited GCR/HSP-70 dysregulation in the brain, triggering a state of stress that could decrease tissue anti-inflammatory action without favoring glial proliferation and make the nervous system more vulnerable. MDPI 2021-05-12 /pmc/articles/PMC8151023/ /pubmed/34065959 http://dx.doi.org/10.3390/ijms22105103 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Othman, Haifa
López-Furelos, Alberto
Leiro-Vidal, José Manuel
Ammari, Mohamed
Sakly, Mohsen
Abdelmelek, Hafedh
Salas-Sánchez, Aarón Ángel
Ares-Pena, Francisco
López-Martín, Elena
Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain
title Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain
title_full Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain
title_fullStr Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain
title_full_unstemmed Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain
title_short Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain
title_sort exposure to 2.45 ghz radiation triggers changes in hsp-70, glucocorticoid receptors and gfap biomarkers in rat brain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151023/
https://www.ncbi.nlm.nih.gov/pubmed/34065959
http://dx.doi.org/10.3390/ijms22105103
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