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Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage
Post-translational modifications based on redox reactions “switch on-off” the biological activity of different downstream targets, modifying a myriad of processes and providing an efficient mechanism for signaling regulation in physiological and pathological conditions. Such modifications depend on...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151040/ https://www.ncbi.nlm.nih.gov/pubmed/34066806 http://dx.doi.org/10.3390/antiox10050749 |
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author | Buelna-Chontal, Mabel García-Niño, Wylly R. Silva-Palacios, Alejandro Enríquez-Cortina, Cristina Zazueta, Cecilia |
author_facet | Buelna-Chontal, Mabel García-Niño, Wylly R. Silva-Palacios, Alejandro Enríquez-Cortina, Cristina Zazueta, Cecilia |
author_sort | Buelna-Chontal, Mabel |
collection | PubMed |
description | Post-translational modifications based on redox reactions “switch on-off” the biological activity of different downstream targets, modifying a myriad of processes and providing an efficient mechanism for signaling regulation in physiological and pathological conditions. Such modifications depend on the generation of redox components, such as reactive oxygen species and nitric oxide. Therefore, as the oxidative or nitrosative milieu prevailing in the reperfused heart is determinant for protective signaling, in this review we defined the impact of redox-based post-translational modifications resulting from either oxidative/nitrosative signaling or oxidative/nitrosative stress that occurs during reperfusion damage. The role that cardioprotective conditioning strategies have had to establish that such changes occur at different subcellular levels, particularly in mitochondria, is also presented. Another section is devoted to the possible mechanism of signal delivering of modified proteins. Finally, we discuss the possible efficacy of redox-based therapeutic strategies against reperfusion damage. |
format | Online Article Text |
id | pubmed-8151040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81510402021-05-27 Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage Buelna-Chontal, Mabel García-Niño, Wylly R. Silva-Palacios, Alejandro Enríquez-Cortina, Cristina Zazueta, Cecilia Antioxidants (Basel) Review Post-translational modifications based on redox reactions “switch on-off” the biological activity of different downstream targets, modifying a myriad of processes and providing an efficient mechanism for signaling regulation in physiological and pathological conditions. Such modifications depend on the generation of redox components, such as reactive oxygen species and nitric oxide. Therefore, as the oxidative or nitrosative milieu prevailing in the reperfused heart is determinant for protective signaling, in this review we defined the impact of redox-based post-translational modifications resulting from either oxidative/nitrosative signaling or oxidative/nitrosative stress that occurs during reperfusion damage. The role that cardioprotective conditioning strategies have had to establish that such changes occur at different subcellular levels, particularly in mitochondria, is also presented. Another section is devoted to the possible mechanism of signal delivering of modified proteins. Finally, we discuss the possible efficacy of redox-based therapeutic strategies against reperfusion damage. MDPI 2021-05-08 /pmc/articles/PMC8151040/ /pubmed/34066806 http://dx.doi.org/10.3390/antiox10050749 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Buelna-Chontal, Mabel García-Niño, Wylly R. Silva-Palacios, Alejandro Enríquez-Cortina, Cristina Zazueta, Cecilia Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage |
title | Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage |
title_full | Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage |
title_fullStr | Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage |
title_full_unstemmed | Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage |
title_short | Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage |
title_sort | implications of oxidative and nitrosative post-translational modifications in therapeutic strategies against reperfusion damage |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151040/ https://www.ncbi.nlm.nih.gov/pubmed/34066806 http://dx.doi.org/10.3390/antiox10050749 |
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