Cargando…

Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage

Post-translational modifications based on redox reactions “switch on-off” the biological activity of different downstream targets, modifying a myriad of processes and providing an efficient mechanism for signaling regulation in physiological and pathological conditions. Such modifications depend on...

Descripción completa

Detalles Bibliográficos
Autores principales: Buelna-Chontal, Mabel, García-Niño, Wylly R., Silva-Palacios, Alejandro, Enríquez-Cortina, Cristina, Zazueta, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151040/
https://www.ncbi.nlm.nih.gov/pubmed/34066806
http://dx.doi.org/10.3390/antiox10050749
_version_ 1783698289888067584
author Buelna-Chontal, Mabel
García-Niño, Wylly R.
Silva-Palacios, Alejandro
Enríquez-Cortina, Cristina
Zazueta, Cecilia
author_facet Buelna-Chontal, Mabel
García-Niño, Wylly R.
Silva-Palacios, Alejandro
Enríquez-Cortina, Cristina
Zazueta, Cecilia
author_sort Buelna-Chontal, Mabel
collection PubMed
description Post-translational modifications based on redox reactions “switch on-off” the biological activity of different downstream targets, modifying a myriad of processes and providing an efficient mechanism for signaling regulation in physiological and pathological conditions. Such modifications depend on the generation of redox components, such as reactive oxygen species and nitric oxide. Therefore, as the oxidative or nitrosative milieu prevailing in the reperfused heart is determinant for protective signaling, in this review we defined the impact of redox-based post-translational modifications resulting from either oxidative/nitrosative signaling or oxidative/nitrosative stress that occurs during reperfusion damage. The role that cardioprotective conditioning strategies have had to establish that such changes occur at different subcellular levels, particularly in mitochondria, is also presented. Another section is devoted to the possible mechanism of signal delivering of modified proteins. Finally, we discuss the possible efficacy of redox-based therapeutic strategies against reperfusion damage.
format Online
Article
Text
id pubmed-8151040
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81510402021-05-27 Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage Buelna-Chontal, Mabel García-Niño, Wylly R. Silva-Palacios, Alejandro Enríquez-Cortina, Cristina Zazueta, Cecilia Antioxidants (Basel) Review Post-translational modifications based on redox reactions “switch on-off” the biological activity of different downstream targets, modifying a myriad of processes and providing an efficient mechanism for signaling regulation in physiological and pathological conditions. Such modifications depend on the generation of redox components, such as reactive oxygen species and nitric oxide. Therefore, as the oxidative or nitrosative milieu prevailing in the reperfused heart is determinant for protective signaling, in this review we defined the impact of redox-based post-translational modifications resulting from either oxidative/nitrosative signaling or oxidative/nitrosative stress that occurs during reperfusion damage. The role that cardioprotective conditioning strategies have had to establish that such changes occur at different subcellular levels, particularly in mitochondria, is also presented. Another section is devoted to the possible mechanism of signal delivering of modified proteins. Finally, we discuss the possible efficacy of redox-based therapeutic strategies against reperfusion damage. MDPI 2021-05-08 /pmc/articles/PMC8151040/ /pubmed/34066806 http://dx.doi.org/10.3390/antiox10050749 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Buelna-Chontal, Mabel
García-Niño, Wylly R.
Silva-Palacios, Alejandro
Enríquez-Cortina, Cristina
Zazueta, Cecilia
Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage
title Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage
title_full Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage
title_fullStr Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage
title_full_unstemmed Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage
title_short Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage
title_sort implications of oxidative and nitrosative post-translational modifications in therapeutic strategies against reperfusion damage
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151040/
https://www.ncbi.nlm.nih.gov/pubmed/34066806
http://dx.doi.org/10.3390/antiox10050749
work_keys_str_mv AT buelnachontalmabel implicationsofoxidativeandnitrosativeposttranslationalmodificationsintherapeuticstrategiesagainstreperfusiondamage
AT garcianinowyllyr implicationsofoxidativeandnitrosativeposttranslationalmodificationsintherapeuticstrategiesagainstreperfusiondamage
AT silvapalaciosalejandro implicationsofoxidativeandnitrosativeposttranslationalmodificationsintherapeuticstrategiesagainstreperfusiondamage
AT enriquezcortinacristina implicationsofoxidativeandnitrosativeposttranslationalmodificationsintherapeuticstrategiesagainstreperfusiondamage
AT zazuetacecilia implicationsofoxidativeandnitrosativeposttranslationalmodificationsintherapeuticstrategiesagainstreperfusiondamage