Donor-Derived Cell-Free DNA in Kidney Transplantation: Origins, Present and a Look to the Future

Since its first detection in 1948, donor-derived cell-free DNA (dd-cfDNA) has been employed for a myriad of indications in various medical specialties. It has had a far-reaching impact in solid organ transplantation, with the most widespread utilization in kidney transplantation for the surveillance...

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Detalles Bibliográficos
Autores principales: Kant, Sam, Brennan, Daniel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151129/
https://www.ncbi.nlm.nih.gov/pubmed/34065914
http://dx.doi.org/10.3390/medicina57050482
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author Kant, Sam
Brennan, Daniel C.
author_facet Kant, Sam
Brennan, Daniel C.
author_sort Kant, Sam
collection PubMed
description Since its first detection in 1948, donor-derived cell-free DNA (dd-cfDNA) has been employed for a myriad of indications in various medical specialties. It has had a far-reaching impact in solid organ transplantation, with the most widespread utilization in kidney transplantation for the surveillance and detection of allograft rejection. The purpose of this review is to track the arc of this revolutionary test—from origins to current use—along with examining challenges and future prospects though the lens of transplant nephrology.
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spelling pubmed-81511292021-05-27 Donor-Derived Cell-Free DNA in Kidney Transplantation: Origins, Present and a Look to the Future Kant, Sam Brennan, Daniel C. Medicina (Kaunas) Review Since its first detection in 1948, donor-derived cell-free DNA (dd-cfDNA) has been employed for a myriad of indications in various medical specialties. It has had a far-reaching impact in solid organ transplantation, with the most widespread utilization in kidney transplantation for the surveillance and detection of allograft rejection. The purpose of this review is to track the arc of this revolutionary test—from origins to current use—along with examining challenges and future prospects though the lens of transplant nephrology. MDPI 2021-05-12 /pmc/articles/PMC8151129/ /pubmed/34065914 http://dx.doi.org/10.3390/medicina57050482 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kant, Sam
Brennan, Daniel C.
Donor-Derived Cell-Free DNA in Kidney Transplantation: Origins, Present and a Look to the Future
title Donor-Derived Cell-Free DNA in Kidney Transplantation: Origins, Present and a Look to the Future
title_full Donor-Derived Cell-Free DNA in Kidney Transplantation: Origins, Present and a Look to the Future
title_fullStr Donor-Derived Cell-Free DNA in Kidney Transplantation: Origins, Present and a Look to the Future
title_full_unstemmed Donor-Derived Cell-Free DNA in Kidney Transplantation: Origins, Present and a Look to the Future
title_short Donor-Derived Cell-Free DNA in Kidney Transplantation: Origins, Present and a Look to the Future
title_sort donor-derived cell-free dna in kidney transplantation: origins, present and a look to the future
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151129/
https://www.ncbi.nlm.nih.gov/pubmed/34065914
http://dx.doi.org/10.3390/medicina57050482
work_keys_str_mv AT kantsam donorderivedcellfreednainkidneytransplantationoriginspresentandalooktothefuture
AT brennandanielc donorderivedcellfreednainkidneytransplantationoriginspresentandalooktothefuture

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