The Role of Molecular Imaging in a Muscle-Invasive Bladder Cancer Patient: A Narrative Review in the Era of Multimodality Treatment

Diagnostic imaging in bladder cancer plays an important role since it is needed from pretreatment staging to follow-up, but a morphological evaluation performed with both CT and MRI showed low sensitivities and specificities in detecting pathologic lymph nodes, due to the occurrence of false positiv...

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Autores principales: Cuccurullo, Vincenzo, Di Stasio, Giuseppe Danilo, Manti, Francesco, Arcuri, Pierpaolo, Damiano, Rocco, Cascini, Giuseppe Lucio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151158/
https://www.ncbi.nlm.nih.gov/pubmed/34064755
http://dx.doi.org/10.3390/diagnostics11050863
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author Cuccurullo, Vincenzo
Di Stasio, Giuseppe Danilo
Manti, Francesco
Arcuri, Pierpaolo
Damiano, Rocco
Cascini, Giuseppe Lucio
author_facet Cuccurullo, Vincenzo
Di Stasio, Giuseppe Danilo
Manti, Francesco
Arcuri, Pierpaolo
Damiano, Rocco
Cascini, Giuseppe Lucio
author_sort Cuccurullo, Vincenzo
collection PubMed
description Diagnostic imaging in bladder cancer plays an important role since it is needed from pretreatment staging to follow-up, but a morphological evaluation performed with both CT and MRI showed low sensitivities and specificities in detecting pathologic lymph nodes, due to the occurrence of false positive results. Implementation of functional information provided by PET/CT could be a determinant in the management of patients with muscle-invasive bladder cancer. A focus on the role of (18)F-FDG PET/CT and alternative tracers in patients with muscle-invasive bladder cancer is provided in this analysis in order to outline its potential applications in staging settings and response evaluation after neoadjuvant chemotherapy.
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spelling pubmed-81511582021-05-27 The Role of Molecular Imaging in a Muscle-Invasive Bladder Cancer Patient: A Narrative Review in the Era of Multimodality Treatment Cuccurullo, Vincenzo Di Stasio, Giuseppe Danilo Manti, Francesco Arcuri, Pierpaolo Damiano, Rocco Cascini, Giuseppe Lucio Diagnostics (Basel) Review Diagnostic imaging in bladder cancer plays an important role since it is needed from pretreatment staging to follow-up, but a morphological evaluation performed with both CT and MRI showed low sensitivities and specificities in detecting pathologic lymph nodes, due to the occurrence of false positive results. Implementation of functional information provided by PET/CT could be a determinant in the management of patients with muscle-invasive bladder cancer. A focus on the role of (18)F-FDG PET/CT and alternative tracers in patients with muscle-invasive bladder cancer is provided in this analysis in order to outline its potential applications in staging settings and response evaluation after neoadjuvant chemotherapy. MDPI 2021-05-11 /pmc/articles/PMC8151158/ /pubmed/34064755 http://dx.doi.org/10.3390/diagnostics11050863 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cuccurullo, Vincenzo
Di Stasio, Giuseppe Danilo
Manti, Francesco
Arcuri, Pierpaolo
Damiano, Rocco
Cascini, Giuseppe Lucio
The Role of Molecular Imaging in a Muscle-Invasive Bladder Cancer Patient: A Narrative Review in the Era of Multimodality Treatment
title The Role of Molecular Imaging in a Muscle-Invasive Bladder Cancer Patient: A Narrative Review in the Era of Multimodality Treatment
title_full The Role of Molecular Imaging in a Muscle-Invasive Bladder Cancer Patient: A Narrative Review in the Era of Multimodality Treatment
title_fullStr The Role of Molecular Imaging in a Muscle-Invasive Bladder Cancer Patient: A Narrative Review in the Era of Multimodality Treatment
title_full_unstemmed The Role of Molecular Imaging in a Muscle-Invasive Bladder Cancer Patient: A Narrative Review in the Era of Multimodality Treatment
title_short The Role of Molecular Imaging in a Muscle-Invasive Bladder Cancer Patient: A Narrative Review in the Era of Multimodality Treatment
title_sort role of molecular imaging in a muscle-invasive bladder cancer patient: a narrative review in the era of multimodality treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151158/
https://www.ncbi.nlm.nih.gov/pubmed/34064755
http://dx.doi.org/10.3390/diagnostics11050863
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